Nitroarenes as Antitubercular Agents: Stereoelectronic Modulation to Mitigate Mutagenicity

À propos
Confidentialité
Mentions légales

Graph Chatbot

Publications associées (32)

Preexisting Heterogeneity of Inducible Nitric Oxide Synthase Expression Drives Differential Growth of Mycobacterium tuberculosis in Macrophages

John McKinney, Ophélie Rutschmann, Chiara Toniolo

Mycobacterium tuberculosis infection is initiated by the inhalation and implantation of bacteria in the lung alveoli, where they are phagocytosed by macrophages. Even a single bacterium may be sufficient to initiate infection. Thereafter, the clinical outc ...

AMER SOC MICROBIOLOGY2022

A microfluidic Braille valve platform for on-demand production, combinatorial screening and sorting of chemically distinct droplets

Wenwei Ma, Christoph Merten, Vida Vafaizadeh

Droplet microfluidics is a powerful tool for a variety of biological applications including single-cell genetics, antibody discovery and directed evolution. All these applications make use of genetic libraries, illustrating the difficulty of generating che ...

NATURE PORTFOLIO2022

Electric-field poling of silicon nitride waveguides for the linear phase modulation

Camille Sophie Brès, Anton Stroganov, Edgars Nitiss, Boris Zabelich

Stoichiometric silicon nitride (Si3N4) constitutes a mature platform for integrated photonics. Its pertinent properties, including wide transparency window from the visible to the mid-IR, low propagation loss, and high third-order nonlinearity, are exploit ...

SPIE-INT SOC OPTICAL ENGINEERING2022

Energy-Efficient Design Techniques for High-Speed Wireline Serial Links

Firat Çelik

The exponential growth in computing power and multimedia services has caused a tremendous increase in data traffic in recent years. This increase in data traffic brings a strong demand for data bandwidth of electrical input/output (I/O) links and pushes th ...

EPFL2021

Optical frequency comb based parallel fm lidar

Tobias Kippenberg, Anton Lukashchuk

In a LIDAR device (100) a laser light source (110) generates first laser light having a first laser frequency which is frequency modulated with a first frequency modulation. A non-linear optical element (120) receives the first laser light and generates th ...

2021

High speed, complex wavefront shaping using the digital micro-mirror device

Demetri Psaltis, Ahmed Ayoub

Digital micro-mirror devices (DMDs) have been deployed in many optical applications. As compared to spatial light modulators (SLMs), they are characterized by their much faster refresh rates (full-frame refresh rates up to 32 kHz for binary patterns) compa ...

Nature Portfolio2021

Implantable Neuro-Modulation Devices and Technology

Alexandre Schmid

Implantable electronic medical devices that operate in closed-loop allow efficient neuro-modulation. Area and power are to be carefully balanced to improve the system autonomy and safety. New digital modulation schemes with implementation in the front-end ...

IEEE, ELECTRON DEVICES SOC & RELIABILITY GROUP2021

Ultrafast Photon-Induced Tunneling Microscopy

Klaus Kern, Yang Luo

Unification of the techniques of ultrafast science and scanning tunneling microscopy (STM) has the potential of tracking electronic motion in molecules simultaneously in real space and real time. Laser pulses can couple to an STM junction either in the wea ...

AMER CHEMICAL SOC2021

Simulation and experimental study of proton bunch self-modulation in plasma with linear density gradients

Patrick Blanchard, Ambrogio Fasoli, Ivo Furno, Yanis Andrebe, Alban Sublet, Sun Hee Kim, Falk Hans Braunmüller, Riccardo Agnello, Christine Stollberg

We present numerical simulations and experimental results of the self-modulation of a long proton bunch in a plasma with linear density gradients along the beam path. Simulation results agree with the experimental results reported [F. Braunmller, T. Nechae ...

2021

X-Band Aom On Chip

Tobias Kippenberg, Junqiu Liu, Anat Siddharth

Silicon Nitride integrated photonic circuits have drawn much attention owing to its ultra-low loss and large Kerr nonlinearity. However, the lack of Pockels effect makes it difficult to be modulated clectro-optically, which posts a major challenge for the ...

IEEE2021

High-content, targeted RNA-seq screening in organoids for drug discovery in colorectal cancer

Jörg Hülsken, Paloma Ordonez Moran, Maxim Norkin

Organoids allow the recapitulation of intestinal homeostasis and cancerogenesis in vitro; however, RNA sequencing (RNA-seq)-based methods for drug screens are missing. We develop targeted organoid sequencing (TORNADO-seq), a high-throughput, high-content d ...

2021

Methods to Enhance Nuclear Magnetic Resonance Sensitivity at High Magnetic Field

Claudia Christina Zanella

MR is a well-established technique routinely used in preclinical and clinical studies. This thesis focussed on the improvement of sensitivity of different methods in MR. Hyperpolarized 129Xe gas is used for studying pulmonary disease or cerebral perfusion ...

EPFL2021

Page 2 sur 2