Rational combination platform trial design for children and young adults with Diffuse Midline Glioma: a report from PNOC

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Computational conceptual design — typological exploration of spatial truss systems through optimization

Corentin Jean Dominique Fivet, Jonas Warmuth

Exploring a wide range of design options is crucial for every sound conceptual design process. In the conventional structural design workflow, optimization techniques are generally employed to generate well-performing design options. However, focusing only ...

International Association for Shell and Spatial Structures (IASS)2023

Interactive design with optimum matchmaking of reused structural elements – a software implementation

Corentin Jean Dominique Fivet, Jan Friedrich Georg Brütting, Jonas Warmuth

Structural systems are a significant contributor to buildings’ embodied carbon and reusing structural elements in new load-bearing applications is one strategy to reduce this impact. However, integrating this approach into existing design workflows without ...

International Association for Shell and Spatial Structures (IASS)2023

Tumor dormancy: EMT beyond invasion and metastasis

Cathrin Brisken, Patrik Aouad, Hazel Margaret Quinn

More than two-thirds of cancer-related deaths are attributable to metastases. In some tumor types metastasis can occur up to 20 years after diagnosis and successful treatment of the primary tumor, a phenomenon termed late recurrence. Metastases arise from ...

WILEY2023

Collective data-based drawings A common ground for adaptive contributive design

The laboratory ALICE (Atelier de la Conception de l’Espace) at the École Polytechnique Fédérale de Lausanne (EPFL) advances a comprehensive approach to data-based drawing oriented towards architectural and urban co-design processes. This drawing methodolog ...

2023

Computational Conceptual Design – Typological Exploration Of Spatial Truss Systems Through Optimization

Corentin Jean Dominique Fivet, Jonas Warmuth

Exploring a wide range of relevant design options from the outset is crucial for every sound conceptual design process. Optimization techniques are generally employed to generate well-performing structural design options. However, focusing only on performa ...

2023

TRACE: A Conceptual Model to Guide the Design of Educational Chatbots

Denis Gillet, Maria Jesus Rodriguez Triana, Adrian Christian Holzer, Juan Carlos Farah, Sandy Ingram, Basile Maurice Pierre Spaenlehauer, Fanny Kim-Lan Lasne

Driven by the rising popularity of chatbots such as ChatGPT, there is a budding line of research proposing guidelines for chatbot design, both in general and specifically for digital education. Nevertheless, few researchers have focused on providing concep ...

Springer2023

Leveraging the Snap Buckling of Bistable Magnetic Shells to Design a Refreshable Braille Dot

Pedro Miguel Nunes Pereira de Almeida Reis, Tian Chen, Arefeh Abbasi, Bastien Freddy Gustave Aymon

A design concept is proposed for the building block, a dot, of programmable braille readers utilizing bistable shell buckling, magnetic actuation, and pneumatic loading. The design process is guided by Finite Element simulations, which are initially valida ...

Wiley2023

KRAB zinc finger proteins link heterochromatin maintenance to replicative stress and inflammation in diffuse large B-cell lymphoma

Filipe Amândio Brandão Sanches Vong Martins

Genomic instability enhances cancer progression by favoring clonal diversity, yet uncontrolled replicative stress can lead to mitotic catastrophe and inflammatory responses promoting immune rejection. KRAB-containing zinc finger proteins (KZFPs) are epigen ...

EPFL2023

Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth

Michele De Palma, Mauro Delorenzi, Mario Leonardo Squadrito, Nadine Fournier, Sina Nassiri

Stem and progenitor cells residing in the intestinal crypts drive the majority of colorectal cancers (CRCs), yet vascular contribution to this niche remains largely unexplored. Vascular endothelial growth factor A (VEGFA) is a key driver of physiological a ...

Springernature2022

An autonomous microfluidic device for identification and analysis of individual clinically-relevant mammalian cells

Fabien Louis Claude Robert Jammes

Cancer represents one of the major public health challenges worldwide, representing more than 25% of all deaths in the European Union in 2014. It affects a large and growing part of the general population, with the National Cancer Institute (NCI) estimatin ...

EPFL2021

STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway

Friedrich Beermann

Metastatic melanoma is hallmarked by its ability of phenotype switching to more slowly proliferating, but highly invasive cells. Here, we tested the impact of signal transducer and activator of transcription 3 (STAT3) on melanoma progression in association ...

SPRINGERNATURE2021