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We investigated the impact of thalamus on ongoing cortical activity in the awake, behaving mouse. We demonstrate that the desynchronized cortical state during active behavior is driven by a centrally generated increase in thalamic action potential firing, which can also be mimicked by optogenetic stimulation of the thalamus. The thalamus therefore is key in controlling cortical states.
Friedhelm Christoph Hummel, Takuya Morishita, Maximilian Jonas Wessel, Elena Beanato, Traian Popa, Pierre Theopistos Vassiliadis, Fabienne Windel, Esra Neufeld
Dimitri Nestor Alice Van De Ville, Thomas William Arthur Bolton, Farnaz Delavari