Aging and sarcopenia associate with specific interactions between gut microbes, serum biomarkers and host physiology in rats

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Age-related muscle dysfunction and sarcopenia are major causes of physical incapacitation in older adults and currently lack viable treatment strategies. Here we find that sphingolipids accumulate in mouse skeletal muscle upon aging and that both genetic a ...

The search for an understanding of the causal elements that lead to neurodegenerative diseases has motivated researchers for decades. Today, Alzheimer's disease is the most prevalent form of dementia and affects approximately fifty million people worldwide ...

Muscle stem cells (MuSCs) are the primary source of myogenic progenitors during muscle repair and are essential for the long-term regenerative capacity of skeletal muscle. Following myofiber injury, MuSCs transition from a quiescent to an activated state, ...

Deregulated energy homeostasis represents a hallmark of aging and results from complex gene-by-environment interactions. Here, we discovered that reducing the expression of the gene ech-6 encoding enoyl-CoA hydratase remitted fat diet-induced deleterious e ...

Important brainstem regions are involved in the regulation of rapid eye movement sleep. We hypothesized that brainstem stroke is associated with dysregulated rapid eye movement sleep and related muscle activity. We compared quantitative/qualitative polysom ...

Sustained exposure to a young systemic environment rejuvenates aged organisms and promotes cellular function. However, due to the intrinsic complexity of tissues it remains challenging to pinpoint niche-independent effects of circulating factors on specifi ...

Motor skill acquisition is essential to our survival, as it enables an efficient interaction with the changing world around us. The acquisition of novel sequential tasks, of particular relevance due to their pervasiveness in everyday life activities, can b ...

Magnetic Resonance Spectroscopy (MRS) is the only technique capable of measuring a large number of metabolites simultaneously in vivo. Ultra-high magnetic fields (UHF) combined with ultra-short echo time (TE) sequences allow the detection of high-quality 1 ...

Aerosol mass spectrometry (AMS) and mid-infrared spectroscopy (MIR) are two analytical methods for characterizing the chemical composition of OM. While AMS provides high-temporal-resolution bulk measurements, the extensive fragmentation during the electron ...

In glacier-fed streams, ecological windows of opportunity allow complex microbial biofilms to develop and transiently form the basis of the food web, thereby controlling key ecosystem processes. Using metagenome-assembled genomes, we unravel strategies tha ...

The relationship between age-related changes in brain structural connectivity (SC) and functional connectivity (FC) with cognition is not well understood. Furthermore, it is not clear whether cognition is represented via a similar spatial pattern of FC and ...

Aging and sarcopenia associate with specific interactions between gut microbes, serum biomarkers and host physiology in rats

Chattez avec Graph Search

Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia

Multidisciplinary Investigation of the Gut-Brain Ecosystem in a Model of Alzheimer's Disease

Molecular Regulation of Muscle Stem Cell Fate during Skeletal Muscle Regeneration and Aging

Reduced ech-6 expression attenuates fat-induced lifespan shortening in C. elegans

REM sleep and muscle atonia in brainstem stroke: A quantitative polysomnographic and lesion analysis study

In vivo transcriptomic profiling using cell encapsulation identifies effector pathways of systemic aging

The aging brain as a model to understand motor skill acquisition in humans and its restoration using non-invasive brain stimulation

Advanced metabolite mapping at ultra-high field using 1H-MRS, 1H-MRSI and macromolecules: applications in a rat model of type C hepatic encephalopathy

Fragment ion-functional group relationships in organic aerosols using aerosol mass spectrometry and mid-infrared spectroscopy

Genomic and metabolic adaptations of biofilms to ecological windows of opportunity in glacier-fed streams

Mapping of Structure-Function Age-Related Connectivity Changes on Cognition Using Multimodal MRI