Monobodies as possible next-generation protein therapeutics - a perspective

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Publications associées (29)

Tosyloxybenziodoxolone: A Platform for Performing the Umpolung of Alkynes in One-Pot Transformations

Jérôme Waser, Julien Aymeric Borrel

Ethynylbenziodoxolones (EBXs) are commonly encountered reagents for the electrophilic alkynylation of nucleophiles. Herein, we report a one-pot, two-step process for EBX generation and their direct application in substrate functionalization. Our approach e ...

2021

Comparing performance of discomfort glare metrics in high and low adaptation levels

Marilyne Andersen, Mandana Sarey Khanie, Jan Wienold, Geraldine Cai Ting Quek

Current discomfort glare prediction metrics usually account for at least one of the two categories of effects that induce discomfort glare – the saturation and contrast effects. Saturation-driven metrics (overall illuminance on the eye) are suited for brig ...

2021

Ordinary varieties with trivial canonical bundle are not uniruled

Zsolt Patakfalvi, Maciej Emilian Zdanowicz

We prove that smooth, projective, K-trivial, weakly ordinary varieties over a perfect field of characteristic p>0 are not geometrically uniruled. We also show a singular version of our theorem, which is sharp in multiple aspects. Our work, together with La ...

2021

Low-energy electron holography imaging of conformational variability of single-antibody molecules from electrospray ion beam deposition

Klaus Kern, Stephan Rauschenbach, Sabine Abb, Sven Alexander Szilagyi, Hannah Julia Ochner

Imaging of proteins at the single-molecule level can reveal conformational variability, which is essential for the understanding of biomolecules. To this end, a biologically relevant state of the sample must be retained during both sample preparation and i ...

National Academy of Sciences2021

Global Frobenius liftability I

Maciej Emilian Zdanowicz

We formulate a conjecture characterizing smooth projective varieties in positive characteristic whose Frobenius morphism can be lifted modulo p(2)-we expect that such varieties, after a finite stale cover, admit a toric fibration over an ordinary abelian v ...

2021

Mechanical Activation of Chemical Bonds at Polymer Interfaces

Julian Nicolas Bleich

Polymer brushes are a specific class of polymer thin films in which each chain is tethered to the underlying substrate via one chain end. In sufficiently densely grafted assemblies, the individual polymer chains are forced into an extended chain conformati ...

EPFL2021

Colloidal Synthesis of Cu-M-S (M = V, Cr, Mn) Nanocrystals by Tuning the Copper Precursor Reactivity

Raffaella Buonsanti, Seyedehbehnaz Varandili, Valeria Mantella, James Richard Pankhurst

New ternary and higher order inorganic materials are needed for a large variety of applications, yet their synthesis still represents a chemistry challenge. Herein, we focus on the synthesis of Cu-M-S nanocrystals (where M = V, Cr, Mn) via a wet-chemistry ...

2020

Unsupervised Representation Learning for Gaze Estimation

Jean-Marc Odobez, Yu Yu

Although automatic gaze estimation is very important to a large variety of application areas, it is difficult to train accurate and robust gaze models, in great part due to the difficulty in collecting large and diverse data (annotating 3D gaze is expensiv ...

IEEE2020

A comprehensive error rate for multiple testing

Stephan Morgenthaler, Jean-Philippe Thiran, Djalel Eddine Meskaldji, Dimitri Nestor Alice Van De Ville

Over the last two decades, a large variety of type I error rates and control procedures have been proposed in the field of multiple hypotheses testing. This paper proposes a framework that includes many existing proposals by investigating procedures in whi ...

SPRINGER2020

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