Monobodies as possible next-generation protein therapeutics - a perspective

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Ethynylbenziodoxolones (EBXs) are commonly encountered reagents for the electrophilic alkynylation of nucleophiles. Herein, we report a one-pot, two-step process for EBX generation and their direct application in substrate functionalization. Our approach e ...

Current discomfort glare prediction metrics usually account for at least one of the two categories of effects that induce discomfort glare – the saturation and contrast effects. Saturation-driven metrics (overall illuminance on the eye) are suited for brig ...

We prove that smooth, projective, K-trivial, weakly ordinary varieties over a perfect field of characteristic p>0 are not geometrically uniruled. We also show a singular version of our theorem, which is sharp in multiple aspects. Our work, together with La ...

Imaging of proteins at the single-molecule level can reveal conformational variability, which is essential for the understanding of biomolecules. To this end, a biologically relevant state of the sample must be retained during both sample preparation and i ...

We formulate a conjecture characterizing smooth projective varieties in positive characteristic whose Frobenius morphism can be lifted modulo p(2)-we expect that such varieties, after a finite stale cover, admit a toric fibration over an ordinary abelian v ...

Polymer brushes are a specific class of polymer thin films in which each chain is tethered to the underlying substrate via one chain end. In sufficiently densely grafted assemblies, the individual polymer chains are forced into an extended chain conformati ...

New ternary and higher order inorganic materials are needed for a large variety of applications, yet their synthesis still represents a chemistry challenge. Herein, we focus on the synthesis of Cu-M-S nanocrystals (where M = V, Cr, Mn) via a wet-chemistry ...

Although automatic gaze estimation is very important to a large variety of application areas, it is difficult to train accurate and robust gaze models, in great part due to the difficulty in collecting large and diverse data (annotating 3D gaze is expensiv ...

Over the last two decades, a large variety of type I error rates and control procedures have been proposed in the field of multiple hypotheses testing. This paper proposes a framework that includes many existing proposals by investigating procedures in whi ...

N-Heterocyclic carbenes (NHCs) are the ligands of choice in a large variety of transformations entailing different transition metals. However, the number and variety of chiral NHCs suitable as stereo-controlling ligands in asymmetric catalysis remains limi ...

Life cycle interpretation is the fourth and last phase of life cycle assessment (LCA). Being a "pivot" phase linking all other phases and the conclusions and recommendations from an LCA study, it represents a challenging task for practitioners, who miss ha ...

Computational modeling and simulation have become essential tools in the quest to better understand the brain's makeup and to decipher the causal interrelations of its components. The breadth of biochemical and biophysical processes and structures in the b ...

Monobodies as possible next-generation protein therapeutics - a perspective

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Tosyloxybenziodoxolone: A Platform for Performing the Umpolung of Alkynes in One-Pot Transformations

Comparing performance of discomfort glare metrics in high and low adaptation levels

Ordinary varieties with trivial canonical bundle are not uniruled

Low-energy electron holography imaging of conformational variability of single-antibody molecules from electrospray ion beam deposition

Global Frobenius liftability I

Mechanical Activation of Chemical Bonds at Polymer Interfaces

Colloidal Synthesis of Cu-M-S (M = V, Cr, Mn) Nanocrystals by Tuning the Copper Precursor Reactivity

Unsupervised Representation Learning for Gaze Estimation

A comprehensive error rate for multiple testing

Modular Chiral N-Heterocyclic Carbene Ligands for the Nickel-Catalyzed Enantioselective C-H Functionalization of Heterocycles

Methodological review and detailed guidance for the life cycle interpretation phase

Understanding Computational Costs of Cellular-Level Brain Tissue Simulations Through Analytical Performance Models