Characterization of myelodysplastic syndromes progressing to acute lymphoblastic leukemia

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Principles of checkpoint override

Ahmad Sadeghi

Why biological quality-control systems fail is often mysterious. Specifically, checkpoints such as the DNA damage checkpoint or the spindle assembly checkpoint are overriden after prolonged arrests allowing cells to continue dividing despite the continued ...

EPFL2022

Assessment of the Lightning Performance of overhead distribution lines based on Lightning Location Systems data

Farhad Rachidi-Haeri

This article presents the Lightning Performance (LP) assessment of a realistic portion of the Italian distribution network with the use of probability distributions for lightning parameters inferred from local data recorded by a Lightning Location System ( ...

2022

Minimax rate for optimal transport regression between distributions

Victor Panaretos, Laya Ghodrati

Distribution-on-distribution regression considers the problem of formulating and es-timating a regression relationship where both covariate and response are probability distributions. The optimal transport distributional regression model postulates that th ...

ELSEVIER2022

Removing Algorithmic Discrimination (With Minimal Individual Error)

Rachid Guerraoui, El Mahdi El Mhamdi, Alexandre David Olivier Maurer, Le Nguyen Hoang

We address for the first time the problem of correcting group discriminations within a score function, while minimizing the individual error. Each group is described by a probability density function on the set of profiles. We first solve the problem analy ...

2022

Generalization Error Bounds Via Rényi-, f-Divergences and Maximal Leakage

Michael Christoph Gastpar, Amedeo Roberto Esposito, Ibrahim Issa

In this work, the probability of an event under some joint distribution is bounded by measuring it with the product of the marginals instead (which is typically easier to analyze) together with a measure of the dependence between the two random variables. ...

2021

Notch1-driven T-ALL chromatin landscape is regulated by Tcf1 in hematopoietic progenitors

Mateusz Waldemar Antoszewski

Notch1 receptor signaling is essential for T cell fate specification and physiological thymic T lymphocyte development. Its dysregulation and oncogenic activation are detected in almost 80% of pediatric patients suffering from T cell acute lymphoblastic le ...

EPFL2021

Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1(T315I) and BCR-ABL1(T315I-E255K)

Oliver Hantschel

Resistance remains the major clinical challenge for the therapy of Philadelphia chromosome-positive (Ph+) leukemia. With the exception of ponatinib, all approved tyrosine kinase inhibitors (TKIs) are unable to inhibit the common "gatekeeper" mutation T315I ...

SPRINGER2021

Notch signaling promotes disease initiation and progression in murine chronic lymphocytic leukemia

Freddy Radtke, Ute Koch, Nadine Fournier, Jessica Sordet, Mateusz Waldemar Antoszewski, Marianne Nkosi, Delphine Maude Tardivon

NOTCH1 gain-of-function mutations are recurrent in B-cell chronic lymphocytic leukemia (B-CLL), where they are associated with accelerated disease progression and refractoriness to chemotherapy. The specific role of NOTCH1 in the development and progressio ...

AMER SOC HEMATOLOGY2021

Towards Interactions Through Differentiable-Non-Differentiable Scale Transitions In Scale Relativity Theory

Maria-Alexandra Paun

It is shown that, in the framework of Scale Relativity Theory, correlations of type informational entropy/cross entropy - probability density, in the description of the dynamics of any complex system, can be perceived as interactions. Explaining these inte ...

UNIV POLITEHNICA BUCHAREST, SCI BULL2021

Niche-Mediated Integrin Signaling Supports Steady-State Hematopoiesis in the Spleen

Jörg Hülsken

Outside-in integrin signaling regulates cell fate decisions in a variety of cell types, including hematopoietic stem cells (HSCs). Our earlier published studies showed that interruption of periostin (POSTN) and integrin-av (ITGAV) interaction induces faste ...

American Association of Immunologists ; Oxford University Press2021

A birth-death-migration model for life in astrophysical environments

Claudio Grimaldi

To assess the number of life-bearing worlds in astrophysical environments, it is necessary to take the intertwined processes of abiogenesis (birth), extinction (death), and transfer of life (migration) into account. We construct a mathematical model that i ...

OXFORD UNIV PRESS2021

Learning from demonstration using products of experts: Applications to manipulation and task prioritization

Sylvain Calinon, Emmanuel Pignat

Probability distributions are key components of many learning from demonstration (LfD) approaches, with the spaces chosen to represent tasks playing a central role. Although the robot configuration is defined by its joint angles, end-effector poses are oft ...

2021