Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs

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Publications associées (31)

Balancing NAD(+) deficits with nicotinamide riboside: therapeutic possibilities and limitations

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Alterations in cellular nicotinamide adenine dinucleotide (NAD(+)) levels have been observed in multiple lifestyle and age-related medical conditions. This has led to the hypothesis that dietary supplementation with NAD(+) precursors, or vitamin B3s, could ...

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Investigation of Carboxylic Acid Isosteres and Prodrugs for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme

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Sirtuin 5 (SIRT5) is a protein lysine deacylase enzyme that regulates diverse biology by hydrolyzing epsilon-N-carboxyacyllysine posttranslational modifications in the cell. Inhibition of SIRT5 has been linked to potential treatment of several cancers but ...

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Mechanical Immunoengineering of T Cells for Enhanced Cancer Immunotherapy

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Cancer is one of the leading causes of death globally. Immunotherapy represents one of the most promising cancer treatments inducing complete and durable responses in a fraction of cancer patients. Despite the unprecedented clinical success achieved by T c ...

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Superior visible light-mediated catalytic activity of a novel N-doped, Fe3O4-incorporating MgO nanosheet in presence of PMS: Imidacloprid degradation and implications on simultaneous bacterial inactivation

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Impressive Imidacloprid (IMD) degradation and bacterial inactivation were attained through the photocatalytic activation of peroxymonosulfate (PMS) via a novel, N-doped MgO@Fe3O4, under visible light. After complete characterization (XPS, XRD, FT-IR, FE-SE ...

ELSEVIER2022

Photochemical oxidation of phenols and anilines mediated by phenoxyl radicals in aqueous solution

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Reactive intermediates formed upon irradiation of chromophoric dissolved organic matter (CDOM) contribute to the degradation of various organic contaminants in surface waters. Besides well-studied "short-lived" photo oxidants, such as triplet state CDOM (3 ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Phase transformation induced distortions in red gold alloys

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Red gold alloys owe their warm and attractive colour to the combination of gold and copper atoms. Thanks to their good mechanical properties and resistance to corrosion, red gold alloys are used in luxury industries as well as in dentistry. Around the equi ...

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Disruption of mitochondrial redox homeostasis by enzymatic activation of a trialkylphosphine probe

Jade Noémie Nam Nguyen, Pablo Rivera Fuentes

Redox homeostasis is essential for cell function and its disruption is associated with multiple pathologies. Redox balance is largely regulated by the relative concentrations of reduced and oxidized glutathione. In eukaryotic cells, this ratio is different ...

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Fatal attraction-The role of hypoxia when alpha-synuclein gets intimate with mitochondria

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Alpha-synuclein aggregation and mitochondrial dysfunction are main pathological hallmarks of Parkinson's disease (PD) and several other neurodegenerative diseases, collectively known as synucleinopathies. However, increasing evidence suggests that they may ...

ELSEVIER SCIENCE INC2021

Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease

Joseph Rutkowski, Renuga Devi Rajaram, Elena Katsyuba, Johan Auwerx, Adrienne Joëlle Laurence Mottis

Background. Nicotinamide adenine dinucleotide (NAD(+)) is a ubiquitous coenzyme involved in electron transport and a cosubstrate for sirtuin function. NAD(+) deficiency has been demonstrated in the context of acute kidney injury (AKI). Methods. We studied ...

2021

Method Development towards Orthogonal Electrophile Delivery

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Redox signaling events mediated by reactive electrophilic species (RES) are key players in several cellular processes. However, the studies on RES have been challenging due to their high reactivity towards numerous nucleophilic groups present in the cells ...

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Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function

Matteo Dal Peraro, Maria Josefina Marcaida Lopez

Deficiency of the serine hydrolase prolyl endopeptidase-like (PREPL) causes a recessive metabolic disorder characterized by neonatal hypotonia, feeding difficulties, and growth hormone deficiency. The pathophysiology of PREPL deficiency and the physiologic ...

CELL PRESS2021

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