Publication

Longitudinal Changes in BOLD Variability and Functional Connectivity from Newborn to School-Age in Very Preterm Children

2025

Résumé

Motivation: BOLD-variability predicts cognitive performance (Protzner et al. 2013, Garret et al. 2011), thus may be relevant for studying high-risk populations like preterm infants. Goal(s): This study assesses how RS-fMRI regional BOLD-variability changes from newborn to school-age both longitudinally and cross-sectionally in preterm children compared with full-term controls. Approach: MRI was acquired in 55 very preterm and 27 full-term infants at term-equivalent age, and 14 very preterm and 20 full-term school-age children, of which 11 very preterm and 9 full-term children had longitudinal MRI. Results: Significant increases in BOLD-variability were observed in attention and default mode networks in preterm children, linked to cognitive performance. Impact: Compared to full-term (FT) infants, BOLD-variability is decreased in very preterm (VPT) infants at term-equivalent-age (TEA). It increases from TEA until school-age in VPT children, but not in FT peers. Overall BOLD-variability at school age links to cognitive performance.

Source officielle

https://infoscience.epfl.ch/entities/publication/52455427-2034-4218-8f9b-1c8e94552b4a

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2025

Résumé

Source officielle

https://infoscience.epfl.ch/entities/publication/52455427-2034-4218-8f9b-1c8e94552b4a

À propos de ce résultat

Concepts associés (32)

Preterm birth

Preterm birth, also known as premature birth, is the birth of a baby at fewer than 37 weeks gestational age, as opposed to full-term delivery at approximately 40 weeks. Extreme preterm is less than 28 weeks, very early preterm birth is between 28 and 32 weeks, early preterm birth occurs between 32 and 34 weeks, late preterm birth is between 34 and 36 weeks' gestation. These babies are also known as premature babies or colloquially preemies (American English) or premmies (Australian English).

Grossesse

La grossesse, appelée aussi gestation humaine, est l'état d'une femme enceinte, c'est-à-dire portant un embryon ou un fœtus humain, en principe au sein de l'utérus, qui est dit gravide. En général, elle fait suite à un rapport sexuel, débute selon le point de vue à partir de la fécondation (fusion d'un ovule et d'un spermatozoïde) ou de la nidation (implantation de l'embryon dans l'utérus), et se déroule jusqu'à l'expulsion de l'organisme engendré.

Low birth weight

Low birth weight (LBW) is defined by the World Health Organization as a birth weight of an infant of or less, regardless of gestational age. Infants born with LBW have added health risks which require close management, often in a neonatal intensive care unit (NICU). They are also at increased risk for long-term health conditions which require follow-up over time.

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Publications associées (2)

Longitudinal Changes in BOLD Variability and Functional Connectivity from Newborn to School-Age in Very Preterm Children

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