Close Encounter of the Third Kind: The ER Meets Endosomes at Fission Sites

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Cyclic peptides are attractive for drug discovery due to their excellent binding properties and the potential to cross cell membranes. However, by far not all cyclic peptides are cell permeable, and measuring or predicting their membrane permeability is no ...

The early branching eukaryote Naegleria gruberi can transform transiently from an amoeboid life form lacking centrioles and flagella to a flagellate life form where these elements are present, followed by reversion to the amoeboid state. The mechanisms imp ...

Cells have evolved endocytic pathways to internalize different molecules, to regulate intra-cellular communication and their interaction with external environment. Pathogens have co-evolved with cells to exploit these processes for infections. In particula ...

Still displaying characteristics of their bacterial origin, such as autonomous division, motility, and their own genome, mitochondria remain an elusive component of modern eukaryotes. They produce most of the cell's energy in the form of adenosine triphosp ...

Autophagy is an essential quality control mechanism for maintaining organellar functions in eukaryotic cells. Defective autophagy in pancreatic beta cells has been shown to be involved in the progression of diabetes through impaired insulin secretion under ...

Peroxisomes are eukaryotic organelles that are essential for multiple metabolic pathways, including fatty acid oxidation, degradation of amino acids, and biosynthesis of ether lipids. Consequently, peroxisome dysfunction leads to pediatric-onset neurodegen ...

Volume electron microscopy is the method of choice for the in situ interrogation of cellular ultrastructure at the nanometer scale, and with the increase in large raw image datasets generated, improving computational strategies for image segmentation and s ...

Redox homeostasis is a key factor in maintaining cellular function and health. The main determinant of the intracellular redox potential is ubiquitous glutathione (GSH) together with its oxidized dimer (GSSG). Importantly, both redox equilibrium and GSH ho ...

STARD4 regulates cholesterol homeostasis by transferring cholesterol between the plasma membrane and endoplasmic reticulum. The STARD4 structure features a helix-grip fold surrounding a large hydrophobic cavity holding the sterol. Its access is controlled ...

Bacteria are ubiquitous single cellular organisms. Compared to eukaryotic cells, bacteria have two unique characteristics: the membrane-less nucleoid and the cell wall built of peptidoglycan (PG). In most bacteria, a single circular chromosome is compacted ...

Microstructural evolution during in-pile irradiation, radiation damage effects and fission products behavior in UO2 nuclear fuel are key issues in understanding and for the modeling of the performance as well as safety characteristics of nuclear fuels in t ...

Cells are the smallest operational units of living systems. Through synthesis of various biomolecules and exchange of signals with the environment, cells tightly regulate their composition to realize a specific functional state. The transformation of a cel ...

Zirconium-based cladding tubes, mainly used as fuel cladding materials in light water reactors, serve as the primary barrier insulating the radioactive fission products from the environment. During operation, the cladding interacts with the coolant water, ...

The notion that mitochondria cannot be lost was shattered with the report of an oxymonad Monocercomonoides exilis, the first eukaryote arguably without any mitochondrion. Yet, questions remain about whether this extends beyond the single species and how th ...

Cysteine cathepsins proteases are enzymes that play essential physiological roles, but their activity is also associated to different aspects of cancer progression and to the development of other diseases. Therefore, cysteine cathepsins are relevant and pr ...

Biological research heavily relies on the use of animal models, which has made it difficult to answer specific questions about human biology and disease. However, with the advent of human organoids - miniature versions of tissues generated in 3D human stem ...

Recordings of the physiological history of cells provide insights into biological processes, yet obtaining such recordings is a challenge. To address this, we introduce a method to record transient cellular events for later analysis. We designed proteins t ...

The fruit fly Drosophila melanogaster serves as a powerful model organism for advancing our understanding of biological processes, not just by studying its similarities with other organisms including ourselves but also by investigating its differences to u ...

Adult autologous human epidermal stem cells can be extensively expanded ex vivo for cell and gene therapy. Identifying the mechanisms involved in stem cell maintenance and defining culture conditions to maintain stemness is critical, because an inadequate ...

High throughput wide-field second harmonic imaging enables the label-free imaging of interfacial (< 3 nm thick) water, with a spatial resolution of similar to 370 nm using similar to 100 ms acquisition times per image. The obtained interfacial orientationa ...

Close Encounter of the Third Kind: The ER Meets Endosomes at Fission Sites

Chattez avec Graph Search

Bulk measurement of membrane permeability for random cyclic peptides in living cells to guide drug development

Mechanisms of axoneme and centriole elimination in Naegleria gruberi

S-acylation and lipid exchange at the ER-Golgi membrane contact sites regulate pathogen entry in human cells

Unraveling mitochondrial dynamics: exploring asymmetries and function through advanced microscopy

Regulation of autophagy by perilysosomal calcium: a new player in β-cell lipotoxicity

Fluorescent fatty acid conjugates for live cell imaging of peroxisomes

Modular segmentation, spatial analysis and visualization of volume electron microscopy datasets

HaloTag-Based Tools for Live-Cell Imaging and Elucidation of Organellar Redox Biology

Membrane specificity of the human cholesterol transfer protein STARD4

Resolving bacterial cell biology: from replisome dynamics to cell wall synthesis

Atomic level insight into irradiation effects in nuclear fuel materials

Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics

Investigation of Hydrogen Behaviour in Irradiated Zirconium-Based Fuel Claddings by Neutron Imaging and Complementary Techniques

Genomics of Preaxostyla Flagellates Illuminates the Path Towards the Loss of Mitochondria

Development of cysteine cathepsin inhibitors combined with cell type-specific delivery for the treatment of B-cell lymphoma and solid tumors

Bioengineering human mini-intestines with in vivo-like complexity and function

Recording physiological history of cells with chemical labeling

Centromere structure and function: lessons from Drosophila

Low temperature and mTOR inhibition favor stem cell maintenance in human keratinocyte cultures

Quantified interface chemistry and biophysics via water imaging