Close Encounter of the Third Kind: The ER Meets Endosomes at Fission Sites

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Rhodamines have been continuously optimized in brightness, biocompatibility, and color to fulfill the demands of modern bioimaging. However, the problem of phototoxicity caused by the excited fluorophore under long-term illumination has been largely neglec ...

Recent fuel anomalies at a Swiss power plant have motivated the development at PSI of the "Cycle Check-Up" (CHUP) methodology which consists in performing Monte Carlo transport calculations using nuclide compositions and thermal-hydraulic boundary conditio ...

State-of-the-art object detection and segmentation methods for microscopy images rely on supervised machine learning, which requires laborious manual annotation of training data. Here we present a self-supervised method based on time arrow prediction pre-t ...

Mitochondria are essential organelles participating in numerous cellular functions, including energy harvesting, regulation of homeostasis and apoptosis. Changes in mitochondrial number, morphology, and function not only impact cellular metabolism but also ...

Centrioles are critical for fundamental cellular processes, including signaling, motility, and division. The extent to which centrioles are present after cell cycle exit in a developing organism is not known. The stereotypical lineage of Caenorhabditis ele ...

The systematic use of high-fidelity high-resolution codes which allow the prediction of safety parameters on a local scale, can result in more efficient use of the nuclear fuel and of the nuclear reactor.The Laboratory of Reactor Physics and Thermal-Hydrau ...

Nuclear fusion, with its potential to provide a nearly unlimited energy source, has inspired scientists to work on the development of fusion power plants. Among the various devices designed to harness nuclear fusion, the tokamak confines the fusion fuel, w ...

Adoptive T cell therapyhas successfully been implementedfor thetreatment of cancer. Nevertheless, ex vivo expansion of T cells byartificial antigen-presenting cells (aAPCs) remains cumbersome andcan compromise T cell functionality, thereby limiting their t ...

Regulation of cytokinesis is essential for the cell during its division cycle. Failure to do so can lead to aneuploidy, which can be fatal and lead to senescence or cancer. A useful model organism for studying cytokinesis in eukaryotes is Schizosaccharomyc ...

The ratio of nuclear content to cytoplasmic volume (N/C ratio) is a key regulator driving the maternal-to -zy-gotic transition in most animal embryos. Altering this ratio often impacts zygotic genome activation and de-regulates the timing and outcome of em ...

A central role of brain mitochondria in regulating and influencing social behaviour is emerging. In addition to its important roles as the "powerhouses" of the cell, mitochondria possess a plethora of cellular functions, such as regulating ion homeostasis, ...

Microbial communities perform essential ecosystem functions such as the remineralization of organic carbon that exists as biopolymers. The first step in mineralization is performed by biopolymer degraders, which harbor enzymes that can break down polymers ...

The understanding of cell-cell and cell-matrix interactions via receptor and ligand binding relies on our ability to study the very first events of their contact. Of particular interest is the interaction between a T cell receptor and its cognate peptide-m ...

SARS-CoV-2 infection requires Spike protein-mediated fusion between the viral and cellular membranes. The fusogenic activity of Spike depends on its post-translational lipid modification by host S-acyltransferases, predominantly ZDHHC20. Previous observati ...

Studying the role of molecularly distinct lipid species in cell signaling remains challenging due to a scarcity of methods for performing quantitative lipid biochemistry in living cells. We have recently used lipid uncaging to quantify lipid -pro-tein affi ...

Redox homeostasis is essential for cell function and its disruption is associated with multiple pathologies. Redox balance is largely regulated by the relative concentrations of reduced (GSH) and oxidized (GSSG) glutathione. In eukaryotic cells, this ratio ...

Single-walled carbon nanotubes (SWCNTs) have unique optoelectronic properties that make them suitable for applications ranging from phototherapy to imaging and sensing, but their uptake has mainly been explored in eukaryotic cells. Here the authors explore ...

BackgroundIn tissues and organisms, the coordination of neighboring cells is essential to maintain their properties and functions. Therefore, knowing which cells are adjacent is crucial to understand biological processes that involve physical interactions ...

Tick-borne encephalitis virus is an enveloped, pathogenic, RNA virus in the family Flaviviridae, genus Flavivirus. Viral particles are formed when the nucleocapsid, consisting of an RNA genome and multiple copies of the capsid protein, buds through the end ...

Centrioles are eukaryotic organelles that template the formation of cilia and flagella, as well as organize the microtubule network and the mitotic spindle in animal cells. Centrioles have proximal-distal polarity and a 9 fold radial symmetry imparted by a ...

Close Encounter of the Third Kind: The ER Meets Endosomes at Fission Sites

Chattez avec Graph Search

Gentle Rhodamines for Live-Cell Fluorescence Microscopy

Monte Carlo analysis of BWR geometries using a cycle check-up methodology

Self-supervised Dense Representation Learning for Live-Cell Microscopy with Time Arrow Prediction

Drug Screening in C. elegans to identify new pharmacological mitochondrial stress inducers

Extensive programmed centriole elimination unveiled in C. elegans embryos

Multi-physics Sub-pin Resolution Analysis of a PWR core with nTRACER/CTF for the OECD/NEA TVA Watts Bar 1 Benchmark

Investigation of scrape-off layer and divertor transport using infrared thermography and SOLPS-ITER simulations

Direct In Vivo Activation of T Cells with Nanosized Immunofilaments Inhibits Tumor Growth and Metastasis

Characterisation of conditional alleles of the Schizosaccharomyces pombe cytokinesis regulator byr4

The nuclear-to-cytoplasmic ratio drives cellularization in the close animal relative Sphaeroforma arctica

Powering the social brain: Mitochondria in social behaviour

Interspecies interactions determine growth dynamics of biopolymer- degrading populations in microbial communities

Microfluidic device combining hydrodynamic and dielectrophoretic trapping for the controlled contact between single micro-sized objects and application to adhesion assays

SARS-CoV-2 hijacks a cell damage response, which induces transcription of a more efficient Spike S-acyltransferase

Quantifying single-cell diacylglycerol signaling kinetics after uncaging

Modulation of Subcellular Redox Homeostasis with Trialkylphosphines

Carbon nanotube uptake in cyanobacteria for near-infrared imaging and enhanced bioelectricity generation in living photovoltaics

Nfinder: automatic inference of cell neighborhood in 2D and 3D using nuclear markers

Simultaneous membrane and RNA binding by Tick-Borne Encephalitis Virus capsid protein

Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel