Disentangling Multiple System Atrophy - Structural insights from alpha-synuclein fibrils and tissue pathology

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A slow decline in the autophagy-lysosomal pathway is a hallmark of the normal aging brain. Yet, an acceleration of this cellular function may propel neurodegenerative events. In fact, mutations in genes associated with the autophagy-lysosomal pathway can l ...

The process of protein aggregation, central to neurodegenerative diseases like Huntington’s, is challenging to study due to its unpredictable nature and relatively rapid kinetics. Understanding its biomechanics is crucial for unraveling its role in disease ...

Energy dispersive x-ray (EDX) spectrum imaging yields compositional information with a spatial resolution down to the atomic level. However, experimental limitations often produce extremely sparse and noisy EDX spectra. Under such conditions, every detecte ...

The atomic configuration of phases and their interfaces is fundamental to materials design and engineering. Here, we unveil a transition metal oxide interface, whose formation is driven by energetic influences─epitaxial tensile strain versus oxygen octahed ...

Whole-cell biophotovoltaic (BPV) devices leverage photoautotrophic microorganisms like cyanobacteria to convert sunlight and water into bioelectricity. They are capable of growing on sequestered carbon dioxide (CO2), eliminating the need to add exogenous o ...

The oxidation behavior of stoichiometric Ti0.12Al0.21B0.67 coatings is investigated by scanning transmission electron microscopy (STEM) after oxidizing for 1, 4 and 8 h at 700 degrees C and at 800 and 900 degrees C. In the as deposited state, a similar to ...

Pacinian corpuscles are among the most sensitive mechanoreceptors found in vertebrates, and they are tuned to vibrations in the highest perceptible frequency range (100 to 2000 Hz). One of their anatomical hallmarks is the onion-like cell layers surroundin ...

Since the discovery of graphene in 2004, there has been rapid progress in research on two-dimensional (2D) material’s potential applications with significant impact. Efforts to bring 2D materials closer to industrial production, quality assessment, and sta ...

With the advances in clean technologies, the role of fuel cells and batteries is becoming increasingly vital. Proton exchange membrane fuel cells are known to be the best candidates for low-temperature and portable operations, such as hydrogen cars. The ef ...

The initial and evolving microstructure during the tensile test of two Fe-17Mn-5Si-10Cr-4Ni shape memory alloys, with and without V, C and fabricated by laser powder bed fusion are investigated and compared via electron backscattered diffraction, transmiss ...

Navigating biomedical instruments inside the brain remains challenging and high-risk. The delicate nature of the tissues involved requires the development of cutting-edge robotic technologies to enhance precision and safety. In response to these demands, t ...

Introduction Type C hepatic encephalopathy (HE) is a decompensating event of chronic liver disease leading to severe motor and cognitive impairment. The progression of type C HE is associated with changes in brain metabolite concentrations measured by 1H m ...

Cortical dynamics underlie many cognitive processes and emerge from complex multi-scale interactions, which are challenging to study in vivo. Large-scale, biophysically detailed models offer a tool which can complement laboratory approaches. We present a m ...

The morphology and distribution of nanoscale structures, such as catalytic active nanoparticles and quantum dots on surfaces, have a significant impact on their function. Thus, the capability of monitoring these properties during manufacturing and operatio ...

Disentangling Multiple System Atrophy - Structural insights from alpha-synuclein fibrils and tissue pathology

Chattez avec Graph Search

A novel allosteric GCase modulator prevents Tau accumulation in GBA1WT and GBA1L444P/L444P cellular models

Self-driving microscopy detects the onset of protein aggregation and enables intelligent Brillouin imaging

A Multiscale Bayesian Approach to Quantification and Denoising of Energy-dispersive X-ray Data

Engineering Symmetry Breaking Interfaces by Nanoscale Structural-Energetics in Orthorhombic Perovskite Thin Films

Bioanode engineering for living solar cells

Passivating oxidation behavior of Ti0.12Al0.21B0.67 coatings investigated by scanning transmission electron microscopy and chemical environment dependent density functional theory simulations

Lamellar Schwann Cells in the Pacinian Corpuscle Potentiate Vibration Perception

Comprehensive benchmarking and user guide for the characterization of CVD-grown transition metal chalcogenides

Advanced imaging of gas diffusion layers: A comparison between focused ion beam scanning electron microscopy and X-ray computed tomography

Effect of precipitates on martensite formation and shape memory effect of FeMnSi-based shape memory alloys fabricated by laser powder bed fusion

A Flat Tendon-Driven Continuum Microrobot for Brain Interventions

Diffusion of brain metabolites highlights altered brain microstructure in type C hepatic encephalopathy: a 9.4 T preliminary study

Modeling and simulation of neocortical micro- and mesocircuitry. Part II: Physiology and experimentation

Hard x-ray grazing-incidence ptychography: large field-of-view nanostructure imaging with ultra-high surface sensitivity