Compounds for functionalizing biomaterials

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The drive to develop cartilage implants for the treatment of major defects in the musculoskeletal sys-tem has resulted in a major research thrust towards developing biomaterial devices for cartilage repair. Investigational devices for the restoration of ar ...

Non-covalent interactions are ubiquitous in nature. The diversity and functionality of these interactions are employed by nature as a universal tool for building the molecular mechanism of life. Although weak, these interactions play a key role in both for ...

The proteasome inhibitor bortezomib (BZM) is one of the most potent anti-cancer drugs in the therapy of multiple myeloma. In this study, an adhesive drug delivery system (DDS) for BZM was developed. Therefore, we extended the present DDS concept of polyele ...

Understanding the interactions between biomedical alloys and body fluids is of importance for the successful and safe performance of implanted devices. Albumin, as the first protein that comes in contact with an implant surface, can determine the biocompat ...

Neural interfaces are devices that are implanted into the body and interface electrically with the central (CNS) or peripheral nervous system. They are inserted surgically for short periods of time or chronically to diagnose or treat several neural disease ...

The prediction of implant behavior in vivo by the use of easy-to-perform in vitro methods is of great interest in biomaterials research. Simulated body fluids (SBFs) have been proposed and widely used to evaluate the bone-bonding ability of implant materia ...

BACKGROUND: Fracture fixation in weak bone is still a clinical challenge. Screw augmentation was shown to successfully increase their primary stability. The currently used calcium phosphate or polymeric bone cements, however, present important drawbacks su ...

The prediction of implant behaviors in vivo by the use of easy-to-perform in vitro methods is of great interest in biomaterials research. In the field of bone implants, it is commonly accepted that a spontaneous formation of a hydroxyapatite (HA) layer on ...

Biocompatibility is one of the biggest challenges for biomaterials development. This issue arises in the case of coatings. Calcium phosphate (CP) coatings are currently used to cover femoral stem implants, while calcium titanate (CT) has also been proposed ...

The invention relates to a scaffold material comprising a plurality of particles of a highly porous polymeric material, characterized in that said scaffold material becomes a shapeable paste once hydrated. The specific features of the particle material imp ...

Background Total ankle replacement is associated to a high revision rate. To improve implant survival, the potential advantage of prostheses with fixed bearing compared to mobile bearing is unclear. The objective of this study was to test the hypothesis th ...

Benzothiazinones (BTZs) are a class of compounds found to be extremely potent against both drug-susceptible and drug-resistant Mycobacterium tuberculosis strains. The potency of BTZs is explained by their specificity for their target decaprenylphosphoryl-D ...

Background: orthopaedic surgeons often face clinical situations where improved screw holding power in cancellous bone is needed. Injectable calcium phosphate cements are one option to enhance fixation. Methods: paired screw pullout tests were undertaken in ...

Osteoporosis is a major health problem in our aging society. This metabolic disease, which is characterized by a deterioration of the bone microarchitecture and a significant loss of bone mass, is affecting a rising number of mostly elderly patients. The m ...

Implanted rat bones play a key role in studies involving fracture healing, bone diseases or drugs delivery among other themes. In most of these studies the implants integration also depends on the animal daily activity and musculoskeletal loads, which affe ...

Purpose. To assess the effect of external mechanical microstimuli of controlled magnitude on the microarchitecture of the peri-implant bone beds in rat tibiae. Materials and Methods. Tibiae of forty rats were fitted with two transcutaneous titanium cylinde ...

A conjugate which is capable of specific binding to and inhibition of urokinase-type plasminigen activator (UPA) comprising a polypeptide molecule and a scaffold molecule, wherein said polypeptide molecule is attached to said scaffold molecule by at least ...

Cyclic peptides have a range of properties that make them attractive as therapeutics such as high binding affinity, good target selectivity and low toxicity. While most peptides in the clinic are derived from nature, various powerful in vitro evolution tec ...

In this work, we showed the realization of a fully- implantable device that integrates a microfabricated sensing platform, a coil for power and data transmission and integrated circuits. We described a device intended to test the biocompati- bility of the ...

In lower cancellous apparent bone density, it can be difficult to achieve adequate screw fixation and hence stable fracture fixation. Different strategies have been proposed, one of them is through augmentation using calcium phosphate cement in the region ...

Compounds for functionalizing biomaterials

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A guide to preclinical evaluation of hydrogel-based devices for treatment of cartilage lesions

Structural and analytical identifications of biomolecules by cold ion spectroscopy of non-covalent complexes

Catechol Containing Polyelectrolyte Complex Nanoparticles as Local Drug Delivery System for Bortezomib at Bone Substitute Materials

An Overview of Serum Albumin Interactions with Biomedical Alloys

Integration of hybrid material systems in conformable neural interfaces

Rapid evaluation of bioactive Ti-based surfaces using an in vitro titration method

Non-setting, injectable biomaterials containing particulate hydroxyapatite can increase primary stability of bone screws in cancellous bone

Calcium phosphate formation on titanium-based surfaces: bioactivity evaluated by in vitro methods

Fretting corrosion between bone and calcium phosphate-calcium titanate coatings

Shapeable scaffold material and uses thereof

Fixed and mobile-bearing total ankle prostheses: Effect on tibial bone strain

Characterization of DprE1-Mediated Benzothiazinone Resistance in Mycobacterium tuberculosis

Variability of the pullout strength of cancellous bone screws with cement augmentation

Development of a Bisphosphonate Delivering Hydrogel for the Augmentation of Impaired Peri-Implant Bone

Influence of gait loads on implant integration in rat tibiae: Experimental and numerical analysis

External Mechanical Microstimuli Modulate the Osseointegration of Titanium Implants in Rat Tibiae

Polypeptide inhibitors of urokinase type plasminogen activator

Development of New Bicyclic Peptide Formats and their Application in Directed Evolution

Fabrication and Packaging of a Fully Implantable Biosensor Array

Injectable calcium phosphate cement for augmentation around cancellous bone screws. In vivo biomechanical studies