A Ruthenium Antimetastasis Agent Forms Specific Histone Protein Adducts in the Nucleosome Core

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Foundation models have become a powerful tool in single-cell transcriptomics, enabling broad generalization across tasks such as cell type annotation, data integration, and drug response prediction. Yet, most current models are trained predominantly on hea ...

Microchannel plates are electron multipliers widely used in applications such as particle detection, imaging, or mass spectrometry and are often paired with a photocathode to enable photon detection. Conventional microchannel plates, made of glass fibers, ...

Motivation Many machine learning (ML) models developed to classify phenotype from gene expression data provide interpretations for their decisions, with the aim of understanding biological processes. For many models, including neural networks, interpretati ...

All physical processes can be described, at a fundamental level, through interactions of elementary particles. The Standard Model of particle physics (SM) describes three of the four known fundamental forces and all of the known elementary particles. The a ...

It is well-established that symptomatic cancers evade immune destruction by coalescing tumor microenvironments to suppress adaptive immunity. Additionally, mouse models of cervical and other cancers have revealed a capability of tumors to systemically indu ...

A search for heavy, long-lived, charged particles with large ionization energy loss within the silicon tracker of the CMS experiment is presented. A data set of proton-proton collisions at a center of mass energy at s = 13 TeV, collected in 2017 and 2018 a ...

Traditionally, mass spectrometry (MS) output is the ion abundance plotted versus the ionic mass-to-charge ratio m/z. While employing only commercially available equipment, Charge Determination Analysis (CHARDA) adds a third dimension to MS, estimating for ...

In the era of precision medicine, there is increasing evidence that conventional cytotoxic agents may be suitable candidates for therapeutic drug monitoring (TDM)- guided drug dosage adjustments and patient's tailored personalization of non-selective chemo ...

The efficacy of anti-cancer therapies depends on the genomic composition of the tumor, its microenvironment, spatial organization, and intra-tumor heterogeneity. B-cell lymphomas are a heterogeneous group of tumors emerging from B-cells at different stages ...

Neuroendocrine (NE) transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor prognosis. Up to date, even if patients at high risk of transformation can be identified by the occurrence of Tumor Pro ...

Cysteine cathepsins proteases are enzymes that play essential physiological roles, but their activity is also associated to different aspects of cancer progression and to the development of other diseases. Therefore, cysteine cathepsins are relevant and pr ...

This thesis links two realms of particle accelerator dynamics and precision particle physics. The achievement of precise luminosity measurement at hadron colliders is enabled with dedicated luminometers. For the Run 3 period, the luminometer upgrade was ...

Nuclear fusion, with its potential to provide a nearly unlimited energy source, has inspired scientists to work on the development of fusion power plants. Among the various devices designed to harness nuclear fusion, the tokamak confines the fusion fuel, w ...

A search for Higgs boson pair (HH) production with one Higgs boson decaying to two bottom quarks and the other to two W bosons are presented. The search is done using proton-proton collisions data at a centre-of-mass energy of 13TeV, corresponding to an in ...

Understanding the mechanisms that enable cancer cells to metastasize is essential in preventing cancer progression. Here we examine the metabolic adaptations of metastasis-initiating cells (MICs) in female breast cancer and how those shape their metastatic ...

A key aim of the HighNESS project for the European Spallation Source is to enable cutting-edge particle physics experiments. This volume presents a conceptual design report for the NNBAR experiment. NNBAR would exploit a new cold lower moderator to make th ...

ESP particle collector (1) for collecting particles in a particle containing gas stream, comprising an inlet section (4), a collector section (6), and an electrode arrangement (8), the inlet section comprising a flow tube (10) defining a gas flow channel ( ...

Proteins and lipids decorated with glycans are found throughout biological entities, playing roles in biological functions and dysfunctions. Current analytical strategies for these glycan-decorated biomolecules, termed glycoconjugates, rely on ensemble-ave ...

Breast cancer is the most common type of cancer worldwide. Diagnosing breast cancer relies on clinical examination, imaging and biopsy. A core-needle biopsy enables a morphological and biochemical characterization of the cancer and is considered the gold s ...

Magnetic topological insulators and semimetals are a class of crystalline solids whose properties are strongly influenced by the coupling between non-trivial electronic topology and magnetic spin configurations. Such materials can host exotic electromagnet ...

A Ruthenium Antimetastasis Agent Forms Specific Histone Protein Adducts in the Nucleosome Core

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Abstract IA02: Cancer-specific foundation models: Friend or foe in healthcare AI?

Optimizing photon capture: advancements in amorphous silicon-based microchannel plates

A comparative analysis of gene expression profiling by statistical and machine learning approaches

Measurement of the photon polarisation in B+ -> K+ pi- pi+ gamma decays at LHCb

HPV16-Expressing Tumors Release Multiple IL-1 Ligands to Orchestrate Systemic Immunosuppression Whose Disruption Enables Efficacy of a Therapeutic Vaccine

Search for heavy long-lived charged particles with large ionization energy loss in proton-proton collisions at s = 13 TeV

Adding Color to Mass Spectra of Biopolymers: Charge Determination Analysis (CHARDA) Assigns Charge State to Every Ion Peak

Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) methods for the therapeutic drug monitoring of cytotoxic anticancer drugs: An update

Development of patient-derived lymphomoids with preserved tumor architecture for lymphoma therapy screening

CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation

Development of cysteine cathepsin inhibitors combined with cell type-specific delivery for the treatment of B-cell lymphoma and solid tumors

Precision luminosity measurement at hadron colliders

Investigation of scrape-off layer and divertor transport using infrared thermography and SOLPS-ITER simulations

Search for Higgs boson pair production in the b(b)over-barW+W- decay mode in proton-proton collisions at √s=13 TeV

Metabolic dependencies of metastasis-initiating cells in female breast cancer

HighNESS conceptual design report: Volume II. The NNBAR experiment

Electrostatic particle collector

Direct observation of glycans bonded to proteins and lipids at the single-molecule level

Towards virtual histology with X-ray grating interferometry

Understanding unconventional magnetic order in a candidate axion insulator by resonant elastic x-ray scattering