Canonical Wnt signalling plays essential roles

Jörg Hülsken
2009
Journal Articles

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Jörg Hülsken
2009
Journal Articles

Source officielle

Publications associées (4)

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https://infoscience.epfl.ch/entities/publication/444141b2-22e5-425d-aebb-13ca8e97db9c

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Publications associées (4)

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Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL

Christelle Dubey, Freddy Radtke, Ute Koch, Nadine Fournier, Mateusz Waldemar Antoszewski, Marianne Nkosi, Tara Kimberly Sugrue

NOTCH1 is a well-established lineage specifier for T cells and among the most frequently mutated genes throughout all subclasses of T cell acute lymphoblastic leukemia (T-ALL). How oncogenic NOTCH1 signaling launches a leukemia-prone chromatin landscape du ...

AMER SOC HEMATOLOGY2022

New approaches to uncover the minimally functional hematopoietic niche using the adipocytic differentiation axis: pharmacological modulation and adrenal niche induction

Frédérica Schyrr

Hematopoietic Stem and Progenitor Cells (HSPCs) reside in their niche, a structure that regulates the balance of cellular quiescence, self-renewal and commitment towards differentiated cells. This highly plastic niche is formed by several cellular players, ...

EPFL2022

Bone marrow adiposity and the hematopoietic niche: A historical perspective of reciprocity, heterogeneity, and lineage commitment

Olaia Maria Naveiras Torres-Quiroga, Josefine Catharina Pedersen Tratwal, Shanti Rojas-Sutterlin, Charles Christopher Bataclan

Purpose: Here we review the current knowledge on bone marrow adipocytes (BMAds) as active contributors to the regulation of the hematopoietic niche, and as potentially pivotal players in the progression of hematological malignancies. We highlight the hiera ...

ELSEVIER SCI LTD2021