Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria

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Zebrafish have the capacity to fully regenerate the heart after an injury, which lies in sharp contrast to the irreversible loss of cardiomyocytes after a myocardial infarction in humans. Transcriptomics analysis has contributed to dissect underlying signa ...

BackgroundIn tissues and organisms, the coordination of neighboring cells is essential to maintain their properties and functions. Therefore, knowing which cells are adjacent is crucial to understand biological processes that involve physical interactions ...

There are 377 Krüppel-associated box (KRAB) domain-containing zinc finger proteins (KZFPs) in the human genome, making them the largest family of transcription factors. KZFPs are defined by a N-terminal KRAB domain and several zinc-finger domains arranged ...

The bacterial inactivation kinetics of Escherichia coli (E. coli) by innovative sputtered TiMoON and TiMoON-Ag films under simulated solar light irradiation is accounted for in a detailed, comprehensive and systematic form. This study presents the evidence ...

A porous InGaN/GaN blue light-emitting diode is demonstrated using selective area sublimation. Transmission electron microscopy reveals that the structure is porous down to the Si substrate; however, the porosity is higher in the GaN buffer, while smaller ...

Mitochondrial diseases are rare and severe conditions with debilitating symptoms. Biochemical defects in mitochondria however are common. The difference between these two frequencies is suspected to lie in the capability of the cells to adapt to the homeos ...

A DNA damage-inducible mutagenic gene cassette has been implicated in the emergence of drug resistance in Mycobacterium tuberculosis during anti-tuberculosis (TB) chemotherapy. However, the molecular composition and operation of the encoded 'mycobacterial ...

Lysine L-lactylation [K(L-la)] is a newly discovered histone mark stimulated under conditions of high glycolysis, such as the Warburg effect. K(L-la) is associated with functions that are different from the widely studied histone acetylation. While K(L-la) ...

The growing field of pulsed electron microscopy (PEM) currently suffers from technical challenges, many of which are related to the inefficiency of present pulsed emitters. In this research, we explore semiconductor photoemitters as a replacement of conven ...

In this work, we report on the efficiency of single InGaN/GaN quantum wells (QWs) grown on thin (

This upload contains the relevant scripts, notebooks, and datasets to reproduce the numerically obtained results of the Journal article "Three-dimensional buoyant hydraulic fracture growth: constant release from a point source" by Möri and Lecampion, (2022 ...

Observing the fast dynamics of nanoscale systems is crucial in order to understand and ultimately control their behavior. Characterizing these dynamic processes requires techniques with atomic spatial resolution and a temporal resolution that matches the t ...

Data repository for the following publication: A. Duque-Prata*, H.-Y. Chen*, L. Müller, M. Oppermann, M. Puppin, C. Serpa, C. Bostedt and M. Chergui, “Ultrafast deep-ultraviolet study of photoexcited aqueous Ferrioxalate”, submitted to ChemPhotoCh ...

This dataset contains raw particle number concentration data measured during the year long MOSAiC expedition from October 2019 to September 2020. The measurement was performed in the Swiss aerosol container on the D-deck of Research Vessel Polarstern using ...

Mycobacterium tuberculosis (Mtb) infection is initiated by inhalation of bacteria into lung alveoli, where they are phagocytosed by resident macrophages. Intracellular Mtb replication induces the death of the infected macrophages and the release of bacteri ...

Co-expression of two or more genes at the single-cell level is usually associated with functional co-regulation. While mRNA co-expression-measured as the correlation in mRNA levels-can be influenced by both transcriptional and post-transcriptional events, ...

Numerical data for scattering amplitudes of photons in d=4 obtained by solving various optimisation problems. The data is stored in .txt files. Mathematica notebook is provided for loading and plotting the data. ...

We propose centralized brain observatories for large-scale recordings of neural activity in mice and non-human primates coupled with cloud-based data analysis and sharing. Such observatories will advance reproducible systems neuroscience and democratize ac ...

Krüppel-associated box (KRAB) domain-containing zinc finger proteins (KZFPs) are one of the largest groups of transcription factors encoded by tetrapods, with 378 members in human alone. KZFP genes are often grouped in clusters reflecting amplification by ...

Transposable elements (TEs) contribute to the evolution of gene regulatory networks and are dynamically expressed throughout human brain development and disease. One gene regulatory mechanism influenced by TEs is the miRNA system of post-transcriptional co ...

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria

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Transcriptomic data meta-analysis reveals common and injury model specific gene expression changes in the regenerating zebrafish heart

Nfinder: automatic inference of cell neighborhood in 2D and 3D using nuclear markers

KRAB zinc-finger proteins and their transposable element targets: between antagonism and cooperation

Bacterial inactivation on sputtered TiOMoN and TiOMoN-Ag thin films under solar simulated light

Porous Nitride Light-Emitting Diodes

Mitochondrial respiratory chain dysfunction disrupts intracellular cholesterol homeostasis

Investigating the composition and recruitment of the mycobacterial ImuA'-ImuB-DnaE2 mutasome

Class I histone deacetylases (HDAC1-3) are histone lysine delactylases

Towards semiconducting nano-engineered photocathodes for electron microscopy applications

Investigation of the Impact of Point Defects in InGaN/GaN Quantum Wells with High Dislocation Densities

Data and Workflow to: Three-dimensional buoyant hydraulic fracture growth: constant release from a point source (Möri and Lecampion, (2022))

In Situ and Time-Resolved Transmission Electron Microscopy of Nanoscale Processes

Data for "Ultrafast deep-ultraviolet study of photoexcited aqueous Ferrioxalate"

Continuous raw particle number concentration data in 10 sec resolution, measured in the Swiss aerosol container during MOSAiC 2019/2020

Uptake-independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates

Exploring the role of transcriptional and post-transcriptional processes in mRNA co-expression

Numerical data for scattering amplitudes of photon in d=4

Next-generation brain observatories

Genetic features and genomic targets of human KRAB-zinc finger proteins

Transposable elements contribute to the spatiotemporal microRNA landscape in human brain development