Angiotensin II infusion into ApoE(-/-) mice: a model for aortic dissection rather than abdominal aortic aneurysm?

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Publications associées (31)

The effect of the elongation of the proximal aorta on the estimation of the aortic wall distensibility

Nikolaos Stergiopoulos, Bram Trachet, Stamatia Zoi Pagoulatou, Mauro Ferraro, Vasiliki Bikia, Georgios Rovas

The compliance of the proximal aortic wall is a major determinant of cardiac afterload. Aortic compliance is often estimated based on cross-sectional area changes over the pulse pressure, under the assumption of a negligible longitudinal stretch during the ...

2021

Acute effects of transcatheter aortic valve replacement on the ventricular-aortic interaction

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou, Vasiliki Bikia, Georgios Rovas

Transcatheter aortic valve replacement (TAVR) is increasingly used to treat severe aortic stenosis (AS) patients. However, little is known regarding the direct effect of TAVR on the ventricular-aortic interaction. In the present study, we aimed to investig ...

AMER PHYSIOLOGICAL SOC2020

Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence

Johan Auwerx, Norman Lionel Moullan, Lei Chen

Long noncoding RNAs (lncRNAs) are emerging regulators of biological processes in the vessel wall; however, their role in atherosclerosis remains poorly defined. We used RNA sequencing to profile lncRNAs derived specifically from the aortic intima of Ldlr(- ...

AMER ASSOC ADVANCEMENT SCIENCE2020

Noninvasive estimation of aortic hemodynamics and cardiac contractility using machine learning

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou, Vasiliki Bikia, Georgios Rovas

Cardiac and aortic characteristics are crucial for cardiovascular disease detection. However, noninvasive estimation of aortic hemodynamics and cardiac contractility is still challenging. This paper investigated the potential of estimating aortic systolic ...

Nature Research2020

In vitro Implementation of Photopolymerizable Hydrogels as a Potential Treatment of Intracranial Aneurysms

Dominique Pioletti, Andreas Schmocker, Christophe Moser, Oriane Poupart

Intracranial aneurysms are increasingly being treated with endovascular therapy, namely coil embolization. Despite being minimally invasive, partial occlusion and recurrence are more frequent compared to open surgical clipping. Therefore, an alternative tr ...

2020

Noninvasive Cardiac Output and Central Systolic Pressure From Cuff-Pressure and Pulse Wave Velocity

Nikolaos Stergiopoulos, Bram Trachet, Stamatia Zoi Pagoulatou, Vasiliki Bikia

Goal: We introduce a novel approach to estimate cardiac output (CO) and central systolic blood pressure (cSBP) from noninvasive measurements of peripheral cuff-pressure and carotid-to-femoral pulse wave velocity (cf-PWV). Methods: The adjustment of a previ ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2020

Hemodynamics of ageing, ventricular-arterial coupling and noninvasive assessment of key hemodynamical and cardiac quantities

Stamatia Zoi Pagoulatou

Ageing is a natural process that affects both the anatomical and functional properties of the cardiovascular system and alters the coupling characteristics between the heart and the aorta. These alterations may predispose the cardiovascular system in the d ...

EPFL2020

Co-localization of microstructural damage and excessive mechanical strain at aortic branches in Angiotensin-II-infused mice

Nikolaos Stergiopoulos, Patrick Segers, Bram Trachet, Lydia Aslanidou, Mauro Ferraro, Goran Lovric

Animal models of aortic aneurysm and dissection can enhance our limited understanding of the etiology of these lethal conditions particularly because early-stage longitudinal data are scant in humans. Yet, the pathogenesis of often-studied mouse models and ...

2019

The onset of cardiovascular disease in mice: an image-based, computational-experimental approach

Lydia Aslanidou

In a number of cardiovascular diseases, the paucity of longitudinal human data hinders our understanding of disease evolution and forestalls the discovery of new therapeutic strategies. We therefore heavily rely on animal models to elucidate the mechanisms ...

EPFL2019

Analysis of morphological and haemodynamical indexes in abdominal aortic aneurysms as preliminary indicators of intraluminal thrombus deposition

Alfio Quarteroni, Simone Deparis, Claudia Maria Colciago

In this paper we study the correlation between the Wall Shear Stress (WSS), a haemodynamical index derived from numerical simulations, and an new index MFA-ILT for the characterisation of intraluminal thrombus (ILT) in presence of abdominal aortic aneurysm ...

2020

On the importance of the nonuniform aortic stiffening in the hemodynamics of physiological aging

Nikolaos Stergiopoulos, Bram Trachet, Stamatia Zoi Pagoulatou, Vasiliki Bikia

Mathematical models of the arterial tree constitute a valuable tool to investigate the hemodynamics of aging and pathology. Rendering such models as patient specific could allow for the assessment of central hemodynamic variables of clinical interest. Howe ...

AMER PHYSIOLOGICAL SOC2019

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