Solid-phase peptide synthesis on disulfide-linker resin followed by reductive release affords pure thiol-functionalized peptides

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Newer solid-phase peptide synthesis and release strategies enable the production of short peptides with high purity, allowing direct screening for desired bioactivity without prior chromatographic purification. However, the maximum number of peptides that ...

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Macrocycles offer an attractive format for drug development due to their good binding properties and potential to cross cell membranes. To efficiently identify macrocyclic ligands for new targets, methods for the synthesis and screening of large combinator ...

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DNA-encoded chemical library technologies enable the screening of large combinatorial libraries of chemically and structurally diverse molecules, including short cyclic peptides. A challenge in the combinatorial synthesis of cyclic peptides is the final st ...

Solid-phase peptide synthesis on disulfide-linker resin followed by reductive release affords pure thiol-functionalized peptides

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Harnessing modular approaches in the study of crystalline sorbents

Precious Metals recovery using novel metal-organic framework (MOF)

Radical-Mediated Azidation of Benzylic C-H Bonds and Azidofunctionalization of Alkenes

De novo developed small cyclic peptides that are orally available

Cyclative Release Strategy to Obtain Pure Cyclic Peptides Directly from the Solid Phase

Methods for the generation of large combinatorial macrocycle libraries

Hypervalent Iodine-Mediated Late-Stage Peptide and Protein Functionalization

Methods for high-throughput synthesis and screening of peptide libraries

Solid-phase peptide synthesis in 384-well plates

Small peptide diversification through photoredox-catalyzed oxidative C-terminal modification

Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation

Amphiphilic Iodine(III) Reagents for the Lipophilization of Peptides in Water

Doping In Vivo Alkylation in E. coli by Introducing the Direct Sulfurylation Pathway of S. cerevisiae

A Versatile Method for Site-Specific Chemical Installation of Aromatic Posttranslational Modification Analogs into Proteins

Hydrophobic Interaction and its Small Molecule effect

Development of Photocatalysts towards the Visible-Light driven C-Terminal Bioconjugation of Peptides and Proteins

Engineering novel protein interactions with therapeutic potential using deep learning-guided surface design

De novo development of proteolytically resistant therapeutic peptides for oral administration

Development of Sustainable Carbohydrate-Based Solvents by Acetal Functionalisation of Biomass

Synthesis of DNA‐encoded disulfide‐ and thioether‐cyclized peptides