Observer Placement for Source Localization: the Effect of Budgets and Transmission Variance

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Neonatal Group B Streptococcal Disease in Otherwise Healthy Infants: Failure of Specific Neonatal Immune Responses

Jacques Fellay, Alessandro Borghesi

Only a small proportion of newborn infants exposed to a pathogenic microorganism develop overt infection. Susceptibility to infection in preterm infants and infants with known comorbidities has a likely multifactorial origin and can be often attributed to ...

Frontiers Media Sa2017

Nanotools and molecular techniques to rapidly identify and fight bacterial infections

Sandor Kasas, Giovanni Longo

Reducing the emergence and spread of antibiotic-resistant bacteria is one of the major healthcare issues of our century. In addition to the increased mortality, infections caused by multi-resistant bacteria drastically enhance the healthcare costs, mainly ...

Elsevier2017

Bypassing bacterial infection in phage display by sequencing DNA released from phage particles

Christian Heinis, Xudong Kong, Camille Villequey

Phage display relies on a bacterial infection step in which the phage particles are replicated to perform multiple affinity selection rounds and to enable the identification of isolated clones by DNA sequencing. While this process is efficient for wild-typ ...

2017

Thin films for Healthcare Acquired Infections (HAIs) prevention : materials preparation, testing and characterization

Sami Rtimi

This thesis addresses the preparation of antibacterial surfaces for hospital facilities taking biomedical thin polymer films, textiles and catheter as probes. Magnetron sputtering is used to apply the coatings leading to fast bacterial inactivation in the ...

EPFL2016

Type I Interferon Signaling Prevents IL-1 beta-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue

Alessandra Piersigilli

Type I interferons (IFN-Is) are fundamental for antiviral immunity, but their role in bacterial infections is contradictory and incompletely described. Streptococcus pyogenes activates IFN-I production in innate immune cells, and IFN-I receptor 1 (Ifnar1)- ...

Cell Press2016

Familial segregation of group B streptococcal infection in a consanguineous kindred

Jacques Fellay, Alessandro Borghesi

Two cases of neonatal group B streptococcal (GBS) infection occurring in a large consanguineous kindred are described. The observation suggests that susceptibility to isolated GBS disease in this family may have been the result of an inborn error of immuni ...

Elsevier Sci Ltd2016

In Vitro and In Vivo Effectiveness of an Innovative Silver-Copper Nanoparticle Coating of Catheters To Prevent Methicillin-Resistant Staphylococcus aureus Infection

César Pulgarin, Juan Kiwi, Sami Rtimi, Myriam Koumba Sarah Ballo

In this study, silver/copper (Ag/Cu)-coated catheters were investigated for their efficacy in preventing methicillin-resistant Staphylococcus aureus (MRSA) infection in vitro and in vivo. Ag and Cu were sputtered (67/33% atomic ratio) on polyurethane cathe ...

American Society for Microbiology2016

Energy Proportionality and Workload Consolidation for Latency-Critical Applications

Edouard Bugnion, Christos Kozyrakis, Georgios Prekas, Mia Primorac

Energy proportionality and workload consolidation are important objectives towards increasing efficiency in large-scale datacenters. Our work focuses on achieving these goals in the presence of applications with microsecond-scale tail latency requirements. ...

2015

The emergence of Vibrio pathogens in Europe: ecology, evolution, and pathogenesis (Paris, 11–12th March 2015)

Melanie Blokesch

Global change has caused a worldwide increase in reports of Vibrio-associated diseases with ecosystem-wide impacts on humans and marine animals. In Europe, higher prevalence of human infections followed regional climatic trends with outbreaks occurring dur ...

Frontiers Media SA2015

Infection Spread In Random Geometric Graphs

Ghurumuruhan Ganesan

In this paper we study the speed of infection spread and the survival of the contact process in the random geometric graph G = G (n, r(n), f) of n nodes independently distributed in S = -1/2, 1/2 according to a certain density f(.). In the first part ...

Applied Probability Trust2015

Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence

Bruno Lemaitre, Bart Deplancke, Maroun Bou Sleiman, Andreas Massouras, Dani Osman

Gut immunocompetence involves immune, stress and regenerative processes. To investigate the determinants underlying inter-individual variation in gut immunocompetence, we perform enteric infection of 140 Drosophila lines with the entomopathogenic bacterium ...

Nature Publishing Group2015