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Publication

Familial segregation of group B streptococcal infection in a consanguineous kindred

Jacques Fellay, Alessandro Borghesi
2016
Journal Articles

Résumé

Two cases of neonatal group B streptococcal (GBS) infection occurring in a large consanguineous kindred are described. The observation suggests that susceptibility to isolated GBS disease in this family may have been the result of an inborn error of immunity inherited as a Mendelian autosomal recessive trait. (C) 2016 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license.

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https://infoscience.epfl.ch/entities/publication/64ef8e52-05e1-4fdb-806b-b7803dcbedc2

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Jacques Fellay, Alessandro Borghesi
2016
Journal Articles

Résumé

Source officielle

https://infoscience.epfl.ch/entities/publication/64ef8e52-05e1-4fdb-806b-b7803dcbedc2

À propos de ce résultat

Concepts associés (23)

Infection

An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable disease, is an illness resulting from an infection. Infections can be caused by a wide range of pathogens, most prominently bacteria and viruses. Hosts can fight infections using their immune systems. Mammalian hosts react to infections with an innate response, often involving inflammation, followed by an adaptive response.

Dominance (génétique)

La dominance est, en génétique, une relation entre deux allèles d'un même gène, dans laquelle le phénotype des individus hétérozygotes est déterminé intégralement par l'un des allèles, sans contribution du second. Les deux allèles sont qualifiés de dominant et récessif l'un par rapport à l'autre. On dit aussi qu'un allèle dominant n'a besoin d'être présent qu'en un seul exemplaire pour être exprimé. Ce type de dominance s’appelle la dominance complète, un allèle dominant masque l’expression de l’allèle récessif chez les organismes hétérozygotes.

Subclinical infection

A subclinical infection—sometimes called a preinfection or inapparent infection—is an infection by a pathogen that causes few or no signs or symptoms of infection in the host. Subclinical infections can occur in both humans and animals. Depending on the pathogen, which can be a virus or intestinal parasite, the host may be infectious and able to transmit the pathogen without ever developing symptoms; such a host is called an asymptomatic carrier.

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Familial segregation of group B streptococcal infection in a consanguineous kindred

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