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Polymeric Micelles Loading Proteins through Concurrent Ion Complexation and pH-Cleavable Covalent Bonding for In Vivo Delivery

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Publications associées (34)

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Euclid preparation XXIV. Calibration of the halo mass function in λ(ν)CDM cosmologies

Maurizio Martinelli, Frédéric Courbin, Georges Meylan, Slobodan Ilic, Gianluca Castignani, Austin Chandler Peel

Euclid's photometric galaxy cluster survey has the potential to be a very competitive cosmological probe. The main cosmological probe with observations of clusters is their number count, within which the halo mass function (HMF) is a key theoretical quanti ...

EDP SCIENCES S A2023

Supramolecular Polymer Brushes

Friederike Katharina Metze

Thin polymer coatings present a method to modify the surface properties of underlying substrates. Polymer-coated surfaces have been used as anticorrosive materials, surfaces with special wetting properties, antifriction materials, and as materials for biom ...

EPFL2023

Cosmic void exclusion models and their impact on the distance scale measurements from large-scale structure

Jean-Paul Richard Kneib, Cheng Zhao, Daniel Felipe Forero Sanchez, Amélie Tamone, Andrei Variu

Baryonic Acoustic Oscillations (BAOs) studies based on the clustering of voids and matter tracers provide important constraints on cosmological parameters related to the expansion of the Universe. However, modelling the void exclusion effect is an importan ...

OXFORD UNIV PRESS2023

De novo protein design by inversion of the AlphaFold structure prediction network

Benedict Dieter Gregor Wolf, Bruno Emanuel Ferreira De Sousa Correia, Stéphane Rosset, Casper Alexander Goverde, Hamed Khakzad

De novo protein design enhances our understanding of the principles that govern protein folding and interactions, and has the potential to revolutionize biotechnology through the engineering of novel protein functionalities. Despite recent progress in comp ...

2023

Computer-implemented design of peptide:receptor signaling complexes for enhanced chemotaxis

Patrick Daniel Barth, Robert Everett Jefferson

The present invention relates to a computer-implemented method for engineering the interaction between a protein and a cognate peptide that are capable of forming a molecular complex, wherein the method comprises (a) preparing in silico a library of test p ...

2023

Euclid: Cosmology forecasts from the void-galaxy cross-correlation function with reconstruction

Frédéric Courbin, Georges Meylan

We have investigated the cosmological constraints that can be expected from measurement of the cross-correlation of galaxies with cosmic voids identified in the Euclid spectroscopic survey, which will include spectroscopic information for tens of millions ...

EDP SCIENCES S A2023

TDCOSMO I. An exploration of systematic uncertainties in the inference ofH(0)from time-delay cosmography

Frédéric Courbin

Strong-lensing time delays enable the measurement of the Hubble constant (H0) independently of other traditional methods. The main limitation to the precision of time-delay cosmography is mass-sheet degeneracy (MSD). Some of the previous TDCOSMO analyses b ...

EDP SCIENCES S A2023

Hemoglobin-stabilized gold nanoclusters displaying oxygen transport ability, self-antioxidation, auto-fluorescence properties and long-term storage potential

Victor Carle Adrien Boureau

The development of hemoglobin (Hb)-based oxygen carriers (HBOCs) holds a lot of potential to overcome important drawbacks of donor blood such as a short shelf life or the potential risk of infection. However, a crucial limitation of current HBOCs is the au ...

ROYAL SOC CHEMISTRY2023

Strong and micro lensing in distant quasars

Eric Gérard Guy Paic

Most large galaxies contain Super Massive Black Holes at their centers, drawing matter nearby to form swirling accretion disks emitting electromagnetic radiation. These are Active Galactic Nuclei. The brightest quasars are the most luminous Universe object ...

EPFL2023

First detection of the BAO signal from early DESI data

Cheng Zhao, Anand Stéphane Raichoor, David Schlegel, Andrei Variu

We present the first detection of the baryon acoustic oscillations (BAOs) signal obtained using unblinded data collected during the initial 2 months of operations of the Stage-IV ground-based Dark Energy Spectroscopic Instrument (DESI). From a selected sam ...

Oxford Univ Press2023

De novo designed proteins: a study in engineering novel folds and functions

Alexandra Krina Van Hall-Beauvais

Proteins control nearly every facet of life on a molecular level. Proteins are formed from linear strings of amino acids, which fold into three-dimensional structures that can enact functions. Evolution has created highly efficient proteins in diverse fold ...

EPFL2023

Peptide-Hypervalent Iodine Reagent Chimeras: Enabling Peptide Functionalization and Macrocyclization

Jérôme Waser, Christian Heinis, Xinjian Ji, Xingyu Liu

Herein, we report a novel strategy for the modification of peptides based on the introduction of highly reactive hypervalent iodine reagents-ethynylbenziodoxolones (EBXs)-onto peptides. These peptide-EBXs can be readily accessed, by both solution- and soli ...

Wiley-VCH Verlag GmbH2023

First paleoproteome study of fossil fish otoliths and the pristine preservation of the biomineral crystal host

Anders Meibom, Jaroslaw Hubert Stolarski, Jinming Guo

Otoliths are calcium carbonate components of the stato-acoustical organ responsible for hearing and maintenance of the body balance in teleost fish. During their formation, control over, e.g., morphology and carbonate polymorph is influenced by complex ins ...

Nature Portfolio2023

AAV9-mediated SMN gene therapy rescues cardiac desmin but not lamin A/C and elastin dysregulation in Smn(2B/-) spinal muscular atrophy mice

Bernard Schneider

Structural, functional and molecular cardiac defects have been reported in spinal muscular atrophy (SMA) patients and mouse models. Previous quantitative proteomics analyses demonstrated widespread molecular defects in the severe Taiwanese SMA mouse model. ...

Oxford University Press2023