Publication

Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease

Hilal Lashuel, Yogesh Singh Chauhan, Joan Romani Aumedes
2023
Journal Articles

Abstract

Background Braak's hypothesis states that sporadic Parkinson's disease (PD) follows a specific progression of pathology from the peripheral to the central nervous system, and this progression can be monitored by detecting the accumulation of alpha-Synuclein (alpha-Syn) protein. Consequently, there is growing interest in understanding how the gut (commensal) microbiome can regulate alpha-Syn accumulation, as this could potentially lead to PD.

Official source

https://infoscience.epfl.ch/entities/publication/2ba204cf-e8e3-41fd-803a-9315ead7db19

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Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease

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