Publications associées à In vitro anti-lymphoma activity of the first-in-class pan-NOTCH transcription inhibitor CB-103

Publications associées (31)

Stereotactic radio-neurosurgery for jugular foramen schwannomas

BackgroundStereotactic radiosurgery (SRS) represents a minimally invasive and valuable alternative for jugular foramen schwannomas (JFS), both as upfront and/or adjuvant treatment (in hybrid approaches).MethodsWe conducted a retrospective review of our cas ...

SPRINGER WIEN2024

Inducible CXCL12/CXCR4–dependent extramedullary hematopoietic niches in the adrenal gland

Jessica Sordet, Aurélien Laurent Jean-Charles Oggier

Adult hematopoietic stem and progenitor cells (HSPCs) reside in the bone marrow (BM) hematopoietic niche, which regulates HSPC quiescence, self-renewal, and commitment in a demand-adapted manner. Although the complex BM niche is responsible for adult hemat ...

2024

Proton beam radiation therapy for vestibular schwannomas-tumor control and hearing preservation rates: a systematic review and meta-analysis

Constantin Tuleasca

ObjectiveProton beam therapy is considered, by some authors, as having the advantage of delivering dose distributions more conformal to target compared with stereotactic radiosurgery (SRS). Here, we performed a systematic review and meta-analysis of proton ...

SPRINGER2023

A bispecific nanomodulator to potentiate photothermal cancer immunotherapy

Bing Feng

Photothermal therapy (PTT) has shown great potential in cancer treatment for inducing photothermal ablation and eliciting immune responses. However, PTT-triggered antitumor immunity is severely hampered by the dynamic amplification of programmed cell death ...

2022

GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy

Etienne Meylan, Nadine Fournier, Gael Luis Boivin, Caroline Anne-Lyse Contat, Pierre-Benoit Bernard Ancey, Justine Pascual, Silvia Sabatino

Neutrophils are the most abundant circulating leucocytes and are essential for innate immunity. In cancer, pro- or antitumor properties have been attributed to tumor-associated neutrophils (TAN). Here, focusing on TAN accumulation within lung tumors, we id ...

AMER ASSOC CANCER RESEARCH2021

Involvement of the M-CSF/IL-34/CSF-1R pathway in malignant pleural mesothelioma

Sènan Mickaël Marius Antoine D'Almeida

Background Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer related to asbestos exposure. The tumor microenvironment content, particularly the presence of macrophages, was described as crucial for the development of the disease. This wo ...

2020

Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity

Cathrin Brisken, Georgios Sflomos, Laura Battista

Functional studies giving insight into the biology of circulating tumor cells (CTCs) remain scarce due to the low frequency ofCTCs and lack of appropriate models. Here, we describe the characterization of a novelCTC-derived breast cancer cell line, designa ...

2020

Metabolic plasticity and glucose transporter redundancy dictate lung adenocarcinoma growth

Caroline Anne-Lyse Contat

Lung cancers represent the leading cause of cancer-related deaths worldwide. These pulmonary cancers count several histological subgroups, whose non-small cell lung cancers, subject of our study. We were precisely interested in the most common subtype of n ...

EPFL2020

Optimized antiangiogenic reprogramming of the tumor microenvironment potentiates CD40 immunotherapy

Daniela Pais Ferreira, Martina Stephanie Anne Schmittnägel, Michele De Palma, Alan Nicolas Thierry Guichard, Nicolo Rigamonti

Cancer immunotherapies are increasingly combined with targeted therapies to improve therapeutic outcomes. We show that combination of agonistic anti-CD40 with antiangiogenic antibodies targeting 2 proangiogenic factors, vascular endothelial growth factor A ...

2020

Targeting the oncogenic signaling of the transcription factor STAT3 with potent and selective monobody inhibitors

Grégory La Sala

Many targeted cancer therapies fail to improve the overall survival of patients. Limitations involve low drug selectivity and the rapid development of resistance. Moreover, the majority of oncogenic drivers presently remain considered as undruggable as th ...

EPFL2020

Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer

Mauro Delorenzi, Thibaut François Hugo Richard

Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER-) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due ...

Springer2019

The role of Snail in non-small cell lung cancer

Svenja Johanna Groeneveld

The epithelial-to-mesenchymal transition (EMT) is a developmental program frequently reactivated in cancer. It plays an important role in several aspects of tumor progression, particularly in the acquisition of invasive capacities facilitating metastasis. ...

EPFL2018

Mapping mitochondrial heteroplasmy in a Leydig tumor by laser capture microdissection and cycling temperature capillary electrophoresis

Stephan Morgenthaler, Paul Refinetti

Background: The growth of tumor cells is accompanied by mutations in nuclear and mitochondrial genomes creating marked genetic heterogeneity. Tumors also contain non-tumor cells of various origins. An observed somatic mitochondrial mutation would have occu ...

BioMed Central2017

Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF(high) neutrophils

Etienne Meylan, Julien Robert Rémi Faget

Bone marrow-derived myeloid cells can accumulate within tumors and foster cancer outgrowth. Local immune-neoplastic interactions have been intensively investigated, but the contribution of the systemic host environment to tumor growth remains poorly unders ...

American Association for the Advancement of Science2017

DICERing macrophages for reprogramming TAMs

Michele De Palma, Mario Leonardo Squadrito

Landes Bioscience2016

SiNW-based Biosensors for Profiling Biomarkers in Breast Tumor Tissues

Francesca Puppo

Breast cancer is the most common life-threatening malignancy in women of most developed countries today, with approximately 200,000 new cases diagnosed every year. About 30% of these cases progress to metastatic disease and death. Considering that one-thir ...

EPFL2016

Deficiency for the Cysteine Protease Cathepsin L Impairs Myc-Induced Tumorigenesis in a Mouse Model of Pancreatic Neuroendocrine Cancer

Douglas Hanahan, Ksenya Shchors

Motivated by the recent implication of cysteine protease cathepsin L as a potential target for anti-cancer drug development, we used a conditional MycER(TAM); Bcl-x(L) model of pancreatic neuroendocrine tumorigenesis (PNET) to assess the role of cathepsin ...

Public Library of Science2015

An in vitro model of the tumor-lymphatic microenvironment with simultaneous transendothelial and luminal flows reveals mechanisms of flow enhanced invasion

Melody Swartz, Marco Pisano, Valentina Triacca

The most common cancers, including breast and skin, disseminate initially through the lymphatic system, yet the mechanisms by which tumor cells home towards, enter and interact with the lymphatic endothelium remain poorly understood. Transmural and luminal ...

Royal Soc Chemistry2015

Three-dimensional chemotaxis-driven aggregation of tumor cells

Alessandro De Simone

One of the most important steps in tumor progression involves the transformation from a differentiated epithelial phenotype to an aggressive, highly motile phenotype, where tumor cells invade neighboring tissues. Invasion can occur either by isolated mesen ...

Nature Publishing Group2015

Modeling Tumor Microenvironments In Vitro

Melody Swartz

Tumor progression depends critically upon the interactions between the tumor cells and their microenvironment. The tumor microenvironment is heterogeneous and dynamic; it consists of extracellular matrix, stromal cells, immune cells, progenitor cells, and ...

Asme2014