Large-scale in-silico analysis of CSF dynamics within the subarachnoid space of the optic nerve

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In a previous paper, a new gyrokinetic quasilinear model was proposed to study turbulent momentum transport in tokamaks with up-down asymmetric plasma shaping and toroidal flow shear (Sun et al 2024 Nuclear Fusion 64 036026). In this work, we start by appl ...

In this paper, we consider experimental data available for graphene-based nanolubricants to evaluate their convective heat transfer performance by means of computational fluid dynamics (CFD) simulations. Single-phase models with temperature-dependent prope ...

Implantable neural interfaces with the central and peripheral nervous systems are currently used to restore sensory, motor, and cognitive functions in disabled people with very promising results. They have also been used to modulate autonomic activities to ...

Background :Sensory reafferents are crucial to correct our posture and movements, both reflexively and in a cognitively driven manner. They are also integral to developing and maintaining a sense of agency for our actions. In cases of compromised reafferen ...

Electrical stimulation of the nervous system has emerged as a promising assistive technology in case of many injuries and illnesses across various parts of the nervous system. In particular, the invasive neuromodulation of the peripheral nervous system see ...

We consider fluid flows, governed by the Navier-Stokes equations, subject to a steady symmetry-breaking bifurcation and forced by a weak noise acting on a slow timescale. By generalizing the multiple-scale weakly nonlinear expansion technique employed in t ...

Animals, including humans, exhibit a remarkable variety of complex behaviours. How the nervous system controls all these behaviours ranging from simple, stereotyped movements to flexible, adaptive actions is a central questions of neuroscience. One of the ...

Neuroprostheses have been used clinically for decades, to help restore or preserve brain functions, when pharmaceutical treatments are inefficient. Although great progress in the field has been made over the years to interface with the nervous system, surf ...

A method for optimizing at least one of a geometry, an implantation procedure, and/or stimulation protocol of one or more electrodes for an electrical stimulation of a target structure in a nervous system of a living being by a computer device, the method ...

Glaucoma is one of the leading causes of irreversible blindness worldwide. Glaucoma is defined clinically as the presence of optic nerve head (ONH) degeneration and progressive loss of retinal ganglion cells (RGCs). Intra-ocular pressure (IOP) has been con ...

Preventing the misfolding or aggregation of TDP-43 is the most actively pursued disease-modifying strategy to treat amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. In our work, we provide proof of concept that native state stabili ...

The goal of this work is to use anisotropic adaptive finite elements for the numerical simulation of aluminium electrolysis. The anisotropic adaptive criteria are based on a posteriori error estimates derived for simplified problems. First, we consider an ...

The pathogenic bacterium Streptococcus pneumoniae (S. pneumoniae) can invade the cerebrospinal fluid (CSF) and cause meningitis with devastating consequences. Whether and how sensory cells in the central nervous system (CNS) become activated during bacteri ...

Fluidic systems enable actuation in various applications, such as automotive, medical, and industrial robotics. Miniaturized valves constitute a fundamental controlling element of modern fluidic systems, intriguing the interest of many researchers. This le ...

The hydraulic design, computational analysis, and experimental investigations of a high-speed small-scale turbopump for mobile waste heat recovery applications based on organic Rankine cycle systems are presented in this paper. Such applications demand hig ...

The peripheral nervous system (PNS) regulates the exchange of sensory information and motor commands between the body and the central nervous system. Further, through the autonomic nervous system, the PNS plays a pivotal role in controlling vital physiolog ...

Multi-polar stimulation protocols have been used in the past to increase the selectivity of electrical stimulation of the nervous system. Nonetheless, the number of possible multipolar stimulation protocols is prohibitively large and cannot be explored dur ...

The myelinated white matter tracts of the central nervous system (CNS) are essential for fast transmission of electrical impulses and are often differentially affected in human neurodegenerative diseases across CNS region, age and sex. We hypothesize that ...

This work presents a study of two-phase flow generated inside a rock-flow cell setup. It is characterized by a pipe section filled with fluid (oil in our studies) that is put into oscillation around its mass centre by an electric motor. This type of appara ...

Background Braak's hypothesis states that sporadic Parkinson's disease (PD) follows a specific progression of pathology from the peripheral to the central nervous system, and this progression can be monitored by detecting the accumulation of alpha-Synuclei ...

Large-scale in-silico analysis of CSF dynamics within the subarachnoid space of the optic nerve

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A Quasilinear Model for Momentum Transport Including Rotation and Electron-scale Turbulence

Computational fluid dynamics simulations of the heat transfer properties of graphene-based nanolubricants and application to hydrodynamic lubrication

Organ Neuroprosthetics: Connecting Transplanted and Artificial Organs with the Nervous System

Augmenting locomotor perception by remapping tactile foot sensation to the back

Biophysically accurate and machine learning-based surrogate models to optimize neuroprosthesis design and operation

Noise-induced transitions past the onset of a steady symmetry-breaking bifurcation: The case of the sudden expansion

Uncovering interactions between Descending Neurons as a functional principle of behavioural control

Unraveling behavior and cortical signals to guide the development of soft neuroprostheses for auditory restoration and spreading depolarization

A method and system for optimizing design, implantation, and stimulation protocols of electrodes stimulating the nervous system

Neuroprotection in the Retina: From Preventing Inflammatory Cell Death to Promoting Vascular Stability in the Central Nervous System

Targeting TDP-43 Proteinopathies in Neurodegeneration by its Native-State Stabilization

Adaptive Finite Elements with Large Aspect Ratio. Application to Aluminium Electrolysis

CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection

Highly Efficient Miniaturized Magnetorheological Valves Using Electropermanent Magnets

Design, computational and experimental investigation of a small-scale turbopump for organic Rankine cycle systems

Soft bioelectronic technologies for selective and multimodal peripheral nerve interfaces

Reconstruction of nerve functional topography using recruitment curves enables selective electrical stimulation

Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function

Rock-Flow Cell Parameters Evaluation Using Ultrasound Doppler Velocimetry

Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease