Publications associées à Synthetic Studies on Daphmanidin C and Maytenone Based on Biosynthetic Considerations and Natural Product Hybrids as Tools for Quorum Sensing

Publications associées (25)

Tension-tension fatigue behavior of basalt composite hybrid joints

The tension–tension fatigue behavior of pseudo-ductile hybrid bonded-bolted double lap basalt composite joints, composed of pseudo-ductile adhesives and adherends with multi-directional fiber architecture, was experimentally investigated. The fatigue damag ...

2024

Cyclic Peptides for Drug Development

Christian Heinis, Alexander Lund Nielsen, Xinjian Ji

Cyclic peptides are fascinating molecules abundantly found in nature and exploited as molecular format for drug development as well as other applications, ranging from research tools to food additives. Advances in peptide technologies made over many years ...

Wiley-VCH Verlag GmbH2024

Enhancing higher education through hybrid and flipped learning: Experiences from the GRE@T-PIONEeR project

Yi Zhang, Mathieu Hursin

GRE@T-PIONEeR is a Horizon 2020 project coordinated by Chalmers University of Technology, running over the period 2020-2024. 18 university teachers from 8 different universities located in 6 different countries gathered forces to develop and offer advanced ...

Elsevier Science Sa2024

Quantitative characterization of the inorganic phosphate gene regulatory networks in S. cerevisiae and bottom up engineering an orthogonal gene network

Shiyu Cheng

Gene regulatory networks (GRNs) play a crucial role in an organism's response to changing environmental conditions. Cellular behaviors typically result from the integration of multiple gene outputs, and their regulation often demands precise control of num ...

EPFL2024

Playing Brains: The Ethical Challenges Posed by Silicon Sentience and Hybrid Intelligence in DishBrain

Georg Michael Joachim Starke

The convergence of human and artificial intelligence is currently receiving considerable scholarly attention. Much debate about the resulting Hybrid Minds focuses on the integration of artificial intelligence into the human brain through intelligent brain- ...

2023

The predictive capacity of in vitro preclinical models to evaluate drugs for the treatment of retinoblastoma

Paul Joseph Dyson, Irina Sinenko, Roland Christopher Turnell-Ritson

Retinoblastoma is a rare childhood cancer of the eye. Of the small number of drugs are used to treat retinoblastoma, all have been repurposed from drugs developed for other conditions. In order to find drugs or drug combinations better suited to the improv ...

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD2023

A hybrid microscopic model for multimodal traffic with empirical observations from aerial footage

Nikolaos Geroliminis, Georgios Anagnostopoulos

Microscopic traffic flow models can be distinguished in lane-based or lane-free depending on the degree of lane-discipline. This distinction holds true only if motorcycles are neglected in lane-based traffic. In cities, as opposed to highways, this is an o ...

2023

Artificial intelligence for natural product drug discovery

Philippe Schwaller, Albert Hofstetter, Michael Alexander Skinnider, Florian Huber

Developments in computational omics technologies have provided new means to access the hidden diversity of natural products, unearthing new potential for drug discovery. In parallel, artificial intelligence approaches such as machine learning have led to e ...

Nature Portfolio2023

Expanding computational biochemistry towards complex and non-natural compounds

Anastasia Sveshnikova

In the beginning was the metabolism. The biochemical processes that make life possible transformed the soup of chemicals into the life on Earth we know today. Since then, living organisms have evolved, and life on Earth has become more complex. Living orga ...

EPFL2023

Microresonator Dissipative Kerr Solitons Synchronized to an Optoelectronic Oscillator

Tobias Kippenberg, Wenle Weng, Jijun He

Using phase-modulation-induced potential gradient whose period is synchronized to a microwave opto-electronic oscillator, dissipative Kerr solitons generated in a crystalline optical microresonator are trapped by the soliton tweezing effect, exhibiting a s ...

American Physical Society (APS)2022

Multiobjective Vector Modulation for Improved Control of NPC-Based Multi-Source Inverters in Hybrid Traction Systems

Andrea Cervone

The concept of a multi-source inverter (MSI) based on NPC topology was recently introduced for hybrid-electric powertrains to connect several dc sources to the traction load in a single conversion stage without magnetics. This work proposes a new modulatio ...

2022

Current challenges in understanding the role of enhancers in disease

Bart Deplancke

Enhancers play a central role in the spatiotemporal control of gene expression and tend to work in a cell-type-specific manner. In addition, they are suggested to be major contributors to phenotypic variation, evolution and disease. There is growing eviden ...

Nature Research2022

Engineering synthetic adhesins for biophysical investigation and rewiring of host-microbe interactions

Xavier Jean-Yves Pierrat

Host attachment is often a critical step in the onset of pathogenesis. To attach to host cells, bacteria have evolved a range of adhesins that bind to specific receptors. Some of these adhesins have been thoroughly characterized using biochemical technique ...

EPFL2022

A computational workflow for the expansion of heterologous biosynthetic pathways to natural product derivatives

Vassily Hatzimanikatis, Jasmin Maria Hafner

Plant natural products (PNPs) and their derivatives are important but underexplored sources of pharmaceutical molecules. To access this untapped potential, the reconstitution of heterologous PNP biosynthesis pathways in engineered microbes provides a valua ...

Nature Research2021

Exploring Synthetic Strategies for Nanocrystal/Reticular Framework Hybrids and Their Potential as CO2 Reduction Electrocatalysts

Yannick Thomas Guntern

The electrochemical CO2 reduction reaction (CO2RR) into valuable chemicals has the potential to realize a carbon-neutral energy cycle. Developing catalysts that can achieve high selectivity towards one of the possible reduction products is one of the bigge ...

EPFL2021

Nonlinear Frequency Conversion in the Hybrid Si3N4 - LiNbO3 Integrated Platform

Tobias Kippenberg, Junqiu Liu, Rui Ning Wang, Mikhail Churaev, Viacheslav Snigirev, Terence Albert Emile Blésin

We demonstrate optical frequency comb generation in hybrid high-Q optical microresonators fabricated using direct wafer bonding of photonic Damascene silicon nitride wafer with thin-film lithium niobate-on-insulator (LNOI). The devices enable direct phase ...

IEEE2021

Nonlinear Frequency Conversion in the Hybrid Silicon Nitride - Lithium Niobate Integrated Platform

Tobias Kippenberg, Junqiu Liu, Rui Ning Wang, Mikhail Churaev, Viacheslav Snigirev, Terence Albert Emile Blésin

We demonstrate optical frequency comb generation in hybrid high-Q optical microresonators fabricated using direct wafer bonding of photonic Damascene silicon nitride wafer with thin-film lithium niobate-on-insulator (LNOI). The devices enable direct phase ...

IEEE2021

New Methods for the Integrative Dynamic Modeling of Biomolecular Structures

Sylvain Träger

The true understanding of most cellular functions is only really achievable through the structural determination of their underlying macromolecular assemblies. However, their size, large number of individual components and metastable states make their eluc ...

EPFL2021

Optogenetic control of Neisseria meningitidis Cas9 genome editing using an engineered, light-switchable anti-CRISPR protein

Bruno Emanuel Ferreira De Sousa Correia, Zander Harteveld

Optogenetic control of CRISPR-Cas9 systems has significantly improved our ability to perform genome perturbations in living cells with high precision in time and space. As new Cas orthologues with advantageous properties are rapidly being discovered and en ...

2021

Experimental and Numerical Study on Scour-Protection Methods in a Stilling Basin: Case Study of Chancy-Pougny Dam

Anton Schleiss, Giovanni De Cesare, Erik Bollaert, Sabine Chamoun, Davide Wüthrich

Chancy-Pougny is a run-of-river dam on the Swiss–French border constructed in the early 1920s. Since its commissioning, the operation of the four spillway gates has been responsible for a progressive erosion of the stilling basin. The future scour potentia ...

2021