Extracellular matrix components in peripheral nerve repair: how to affect neural cellular response and nerve regeneration?

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A spinal cord injury (SCI) triggers a cascade of molecular and cellular responses involving inflammatory cell infiltration and cytokine release, apoptosis, demyelination, excitotoxicity, ischemia, and the formation of a fibrotic scar surrounded by an astro ...

This thesis presents an extensive exploration of neuroelectronic interfaces, focusing on microfabrication, in silico modeling, and their applications in designing and fabricating devices for neural interfacing. The research encompasses both peripheral nerv ...

Organoids, miniature tissues generated from self-organizing stem cells within three-dimensional (3D) extracellular matrices (ECM), have opened up exciting possibilities for in vitro studies of complex physiological processes. A key factor in the success of ...

Objective. Selective neuromodulation of deep brain regions has for a long time only been possible through invasive approaches, because of the steep depth-focality trade-off of conventional non-invasive brain stimulation (NIBS) techniques. Approach. An appr ...

Cells are the smallest operational units of living systems. Through synthesis of various biomolecules and exchange of signals with the environment, cells tightly regulate their composition to realize a specific functional state. The transformation of a cel ...

Breast cancer is a significant global health burden, causing a substantial number of deaths. Systemic metastatic tumour cell dissemination is a major cause of poor outcomes. Understanding the mechanisms underlying metastasis is crucial for effective interv ...

Atomic force microscopy (AFM) is a widely used imaging tool for obtaining a variety of information for a range of samples. Although it was initially intended to serve as a method of observing very flat solid surfaces, its use expanded into several other fi ...

Engineered grafts constitute an alternative to autologous transplant for repairing severe peripheral nerve injuries. However, current clinically available solutions have substantial limitations and are not suited for the repair of long nerve defects. A nov ...

Spinal cord injury (SCI) interrupts axonal connections between the brain and the spinal cord, and is characterized by a spectrum of sensorimotor and autonomic impairments. While spontaneous recovery is limited, recent studies have shown that functional imp ...

When a traumatic event causes complete denervation, muscle functional recovery is highly compromised. A possible solution to this issue is the implantation of a biodegradable polymeric tubular scaffold, providing a biomimetic environment to support the ner ...

The peripheral nervous system (PNS) regulates the exchange of sensory information and motor commands between the body and the central nervous system. Further, through the autonomic nervous system, the PNS plays a pivotal role in controlling vital physiolog ...

Here, we show that, in the developing spinal cord, after the early Wnt-mediated Tcf transcription activation that confers dorsal identity to neural stem cells, neurogenesis redirects beta-catenin from the adherens junctions to the nucleus to stimulate Tcfo ...

Nerve injuries cause permanent neurological disability due to limited axonal regeneration. Injury-dependent and-independent mechanisms have provided important insight into neuronal regeneration, however, common denominators underpinning regeneration remain ...

Zebrafish have the capacity to fully regenerate the heart after an injury, which lies in sharp contrast to the irreversible loss of cardiomyocytes after a myocardial infarction in humans. Transcriptomics analysis has contributed to dissect underlying signa ...

Nerve conduits may represent a valuable alternative to autograft for the regeneration of long-gap damages. However, no NCs have currently reached market approval for the regeneration of limiting gap lesions, which still represents the very bottleneck of th ...

JC polyomavirus (JCPyV) is an opportunistic virus that remains in a latent state in the kidneys and lymphoid organs of more than half of the human adult population. In rare cases of severe immune suppression, the virus is able to establish a lytic infectio ...

The myelinated white matter tracts of the central nervous system (CNS) are essential for fast transmission of electrical impulses and are often differentially affected in human neurodegenerative diseases across CNS region, age and sex. We hypothesize that ...

The premotor (PM) and primary motor (M1) cortical areas broadcast voluntary motor commands through multiple neuronal pathways, including the corticorubral projection that reaches the red nucleus (RN). However, the respective contribution of M1 and PM to co ...

Biological research heavily relies on the use of animal models, which has made it difficult to answer specific questions about human biology and disease. However, with the advent of human organoids - miniature versions of tissues generated in 3D human stem ...

Hydrogels are a class of soft materials, which display unique biomimetic properties to biological tissues. Their mechanical properties, high water content, and porosity resemble that of extracellular matrix so that cell growth and proliferation can be reli ...

Extracellular matrix components in peripheral nerve repair: how to affect neural cellular response and nerve regeneration?

Chattez avec Graph Search

Multimodal transcriptomic atlases of mouse spinal cord injury

Modeling, fabrication and validation of 3D neural interfaces for peripheral nerves and brain organoids

Engineering hydrogel microenvironments for epithelial organoid culture

Safety, tolerability and blinding efficiency of non-invasive deep transcranial temporal interference stimulation: first experience from more than 250 sessions

Deciphering the nature of cell state transitions in single cells using quantitative modeling of temporal dynamics

Unveiling breast cancer metastasis through an advanced X-ray imaging approach

Advancements in Nanomechanical Characterization and Biomolecular Imaging with Atomic force Microscopy

A Novel 3D-Printed/Porous Conduit with Tunable Properties to Enhance Nerve Regeneration Over the Limiting Gap Length

Targeted regeneration of spinal cord neurons across a complete injury restores walking

Recent Advances in Polymeric Drug Delivery Systems for Peripheral Nerve Regeneration

Soft bioelectronic technologies for selective and multimodal peripheral nerve interfaces

Neurogenesis redirects β-catenin from adherens junctions to the nucleus to promote axonal growth

The circadian clock time tunes axonal regeneration

Transcriptomic data meta-analysis reveals common and injury model specific gene expression changes in the regenerating zebrafish heart

Improved Physiochemical Properties of Chitosan@PCL Nerve Conduits by Natural Molecule Crosslinking

Comprehensive proteomic analysis of JC polyomavirus-infected human astrocytes and their extracellular vesicles

Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function

Loss of Motor Cortical Inputs to the Red Nucleus after CNS Disorders in Nonhuman Primates

Bioengineering human mini-intestines with in vivo-like complexity and function

Hydrogels and conductive hydrogels for implantable bioelectronics