Transactive response dna-binding protein 43kda (tdp-43) mutants and uses thereof

The invention relates to TDP-43 protein mutants and uses thereof. The invention further relates to methods for the preparation of TDP-43 protein mutants aggregates, including fibrils and uses thereof. The invention further relates to use the TDP-43 protein mutants for the identification and screening of modulators of TDP-43 protein aggregation and related methods.