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The invention relates to TDP-43 protein mutants and uses thereof. The invention further relates to methods for the preparation of TDP-43 protein mutants aggregates, including fibrils and uses thereof. The invention further relates to use the TDP-43 protein mutants for the identification and screening of modulators of TDP-43 protein aggregation and related methods.
Hilal Lashuel, Yllza Jasiqi, Lixin Yang
Hilal Lashuel, Henning Paul-Julius Stahlberg, Galina Limorenko, Rajasekhar Kolla, Meltem Tatli