Co-localization of microstructural damage and excessive mechanical strain at aortic branches in Angiotensin-II-infused mice

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Compliant vascular grafts for implantation in the vasculature are provided. The compliant vascular grafts are designed to expand longitudinally and radially within a blood vessel, such as an artery, and is expected to be particularly well suited for treati ...

Central aortic diastolic pressure decay time constant ( ) is according to the two-element Windkessel model equal to the product of total peripheral resistance (R) times total arterial compliance (C ). As such, it is related to arterial stiffness, which has ...

Aortic diseases are characterized by dire prognosis and inadequate diagnosis, owing to their insidious yet lethal nature. Aortopathies, namely aortic aneurysms and dissections, along with certain congenital diseases, might necessitate surgical replacement ...

Dielectric elastomer actuator augmented aorta (DEA) represents a novel approach with high potential for assisting a failing heart. The soft tubular device replaces a section of the aorta and increases its diameter when activated. The hemodynamic interactio ...

Introduction: Synthetic vascular grafts have been widely used in clinical practice for aortic replacement surgery. Despite their high rates of surgical success, they remain significantly less compliant than the native aorta, resulting in a phenomenon calle ...

The transaortic valvular pressure gradient (TPG) plays a central role in decision-making for patients suffering from severe aortic stenosis. However, the flow-dependence nature of the TPG makes the diagnosis of aortic stenosis challenging since the markers ...

IntroductionArterial wave reflection is an important component of the left ventricular afterload, affecting both pressure and flow to the aorta. The aim of the present study was to evaluate the impact of wave reflection on transvalvular pressure gradients ...

Stroke volume (SV) is a major biomarker of cardiac function, reflecting ventricular-vascular coupling. Despite this, hemodynamic monitoring and management seldomly includes assessments of SV and remains predominantly guided by brachial cuff blood pressure ...

Therapies to accelerate vascular repair are currently lacking. Pre-clinical studies suggest that hydrogen sulfide (H2S), an endogenous gasotransmitter, promotes angiogenesis. Here, we hypothesized that sodium thiosulfate (STS), a clinically relevant source ...

Intracranial aneurysm is a cerebrovascular disease characterized by an artery dilation in the brain. An aneurysm is prone to rupture, which causes a life-threatening subarachnoid hemorrhage. The major drawbacks of the current treatments, open surgical clip ...

An alternative intracranial aneurysm embolic agent is emerging in the form of hydrogels due to their ability to be injected in liquid phase and solidify in situ. Hydrogels have the ability to fill an aneurysm sac more completely compared to solid implants ...

Aims B cell functions in the process of atherogenesis have been investigated but several aspects remain to be clarified. ...

In-vivo assessment of aortic characteristic impedance (Zao) and total arterial compliance (CT) has been hampered by the need for either invasive or inconvenient and expensive methods to access simultaneous recordings of aortic pressure and flow, wall thick ...

Aortic aneurysms and dissections are silent and lethal conditions, whose pathogenesis remains incompletely understood. Although angiotensin II (AngII)-infused ApoE-/- mice have been widely used to study aortic aneurysm and dissection, early morphofunctiona ...

Cardiotrophin-1 (CT-1) is associated with cardiovascular (CV) diseases. We investigated the effect of CT-1 deficiency in the development and progression of atherosclerosis in double knockout Apoe(-/-)ct-1(-/-) mice. Apoe(-/-) C57Bl/6 or Apoe(-/-)ct-1(-/-) ...

The compliance of the proximal aortic wall is a major determinant of cardiac afterload. Aortic compliance is often estimated based on cross-sectional area changes over the pulse pressure, under the assumption of a negligible longitudinal stretch during the ...

Transcatheter aortic valve replacement (TAVR) is increasingly used to treat severe aortic stenosis (AS) patients. However, little is known regarding the direct effect of TAVR on the ventricular-aortic interaction. In the present study, we aimed to investig ...

In a number of cardiovascular diseases, the paucity of longitudinal human data hinders our understanding of disease evolution and forestalls the discovery of new therapeutic strategies. We therefore heavily rely on animal models to elucidate the mechanisms ...

In this paper we study the correlation between the Wall Shear Stress (WSS), a haemodynamical index derived from numerical simulations, and an new index MFA-ILT for the characterisation of intraluminal thrombus (ILT) in presence of abdominal aortic aneurysm ...

Cardiac and aortic characteristics are crucial for cardiovascular disease detection. However, noninvasive estimation of aortic hemodynamics and cardiac contractility is still challenging. This paper investigated the potential of estimating aortic systolic ...

Co-localization of microstructural damage and excessive mechanical strain at aortic branches in Angiotensin-II-infused mice

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Compliant vascular grafts and methods of use

Novel theory and potential applications of central diastolic pressure decay time constant

Compliance-matching vascular grafts with personalization potential

Hemodynamic effects of a dielectric elastomer augmented aorta on aortic wave intensity: An in-vivo study

Design and computational optimization of compliance-matching aortic grafts

The Impact of Left Ventricular Performance and Afterload on the Evaluation of Aortic Valve Stenosis: A 1D Mathematical Modeling Approach

Arterial Wave Reflection and Aortic Valve Stenosis: Diagnostic Challenges and Prognostic Significance

Validation of a Non-invasive Inverse Problem-Solving Method for Stroke Volume

Sodium thiosulfate, a source of hydrogen sulfide, stimulates endothelial cell proliferation and neovascularization

In situ photopolymerizable hydrogels for intracranial aneurysms treatment

Pulsatile Flow-Induced Fatigue-Resistant Photopolymerizable Hydrogels for the Treatment of Intracranial Aneurysms

Follicular regulatory helper T cells control the response of regulatory B cells to a high-cholesterol diet

Determination of Aortic Characteristic Impedance and Total Arterial Compliance From Regional Pulse Wave Velocities Using Machine Learning: An in-silico Study

Early Morphofunctional Changes in AngII-Infused Mice Contribute to Regional Onset of Aortic Aneurysm and Dissection

Cardiotrophin-1 Deficiency Abrogates Atherosclerosis Progression

The effect of the elongation of the proximal aorta on the estimation of the aortic wall distensibility

Acute effects of transcatheter aortic valve replacement on the ventricular-aortic interaction

The onset of cardiovascular disease in mice: an image-based, computational-experimental approach

Analysis of morphological and haemodynamical indexes in abdominal aortic aneurysms as preliminary indicators of intraluminal thrombus deposition

Noninvasive estimation of aortic hemodynamics and cardiac contractility using machine learning