A LIGHTning Strike to the Metastatic Niche

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Adoptive T cell therapyhas successfully been implementedfor thetreatment of cancer. Nevertheless, ex vivo expansion of T cells byartificial antigen-presenting cells (aAPCs) remains cumbersome andcan compromise T cell functionality, thereby limiting their t ...

Lightning discharges between charged clouds and the Earth’s surface are responsible for considerable damages and casualties. It is therefore important to develop better protection methods in addition to the traditional Franklin rod. Here we present the fir ...

The goal of this article is to investigate the effect of frequency-dependent soil models on the performance of grounding electrodes subjected to lightning strikes. Several soil models are examined while accounting for the variation of soil resistivity and ...

Lightning is highly destructive due to its high power density and unpredictable character. Directing lightning away would allow to protect sensitive sites from its direct and indirect impacts (electromagnetic perturbations). Up to now, lasers have been una ...

Lightning discharges, including cloud-to-ground (CG) and intracloud (IC) lightning, are known to emit electromagnetic pulses (EMPs) in a wide frequency band ranging from few Hz up to hundreds MHz [1]. During the breakdown and ionization processes (mostly f ...

Lightning is directly or indirectly responsible for significant human casualties and property damage worldwide. A timely prediction of its occurrence can enable authorities and the public to take necessary precautionary actions resulting in diminishing the ...

Lightning physics is highly multidisciplinary, involving areas such as plasma physics, electrical engineering, meteorology, thermodynamics and particle physics. Upward lightning is a special type of lightning initiated from tall structures that has attract ...

Many human cancers manifest the capability to circumvent attack by the adaptive immune system. In this work, we identified a component of immune evasion that involves frequent up-regulation of fragile X mental retardation protein (FMRP) in solid tumors. FM ...

The Säntis Tower was instrumented in May 2010 to measure currents of lightning discharges striking the tower. Since then the system has been recurrently updated and expanded. Currently, data associated with lightning strikes to the tower are collected at f ...

Stem and progenitor cells residing in the intestinal crypts drive the majority of colorectal cancers (CRCs), yet vascular contribution to this niche remains largely unexplored. Vascular endothelial growth factor A (VEGFA) is a key driver of physiological a ...

Upward lightning is the dominant type of lightning discharge to tall structures. It has been observed that a significant number of these upward flashes are initiated by nearby lightning activity. The aim of this study is to estimate the incidence of upward ...

Background The use of intralesional Mycobacterium bovis BCG (intralesional live BCG) for the treatment of metastatic melanoma resulted in regression of directly injected, and occasionally of distal lesions. However, intralesional-BCG is less effective in p ...

Lightning is formed in the atmosphere through the combination of intricate dynamic and microphysical processes. Mainly due to this complexity, attempts to solve the important problem of lightning prediction have generally failed to yield accurate results. ...

Activin-A, a transforming growth factor ê µ family member, is a pleiotropic cytokine with diverse functions in development, fertility, adult tissue homeostasis, and aging. Accordingly, deregulation of Activin-A signaling has been associated with many patho ...

In the discussed paper [N. Starkman, H. Winch, J. S. Sidhu, and G. Starkman, Straight lightning as a signature of macroscopic dark matter, Phys. Rev. D 103, 063024 (2021)], the authors have made several assumptions and statements concerning the initiation ...

Breast cancer metastasis is a complex process that depends not only on intrinsic characteristics of metastatic stem cells, but also on the particular microenvironment that supports their growth and modulates the plasticity of the system. In search for micr ...

Nearly all the cells of an organism share the same DNA sequence or genome, and yet they show different phenotypes and carry out different functions. This diversity is made possible by a verity of molecular modifications acting on the DNA sequence that coll ...

Solid cancers exhibit a dynamic balance between cell death and proliferation ensuring continuous tumour maintenance and growth(1,2). Increasing evidence links enhanced cancer cell apoptosis to paracrine activation of cells in the tumour microenvironment in ...

We implement an electromagnetic time reversal technique (EMTR) to locate lightning return strokes. The two-dimensional finite difference time domain is employed to simulate the EMTR process in both, the forward-time and the backward-time phases. Scatterers ...

The streamer bursts generated during the initiation and propagation of leaders play an important role in the creation and maintenance of hot discharge channels in air. The most important parameters related to streamer bursts in this respect are the length ...

A LIGHTning Strike to the Metastatic Niche

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Direct In Vivo Activation of T Cells with Nanosized Immunofilaments Inhibits Tumor Growth and Metastasis

Laser-guided lightning

Impact of Frequency-Dependent Soil Models on Grounding System Performance for Direct and Indirect Lightning Strikes

The laser lightning rod project

Lightning interaction with the ionosphere

Lightning Nowcasting Using Solely Lightning Data

Lightning to tall structures: Characterization, Modeling and Protection

Aberrant hyperexpression of the RNA binding protein FMRP in tumors mediates immune evasion

Säntis Lightning Research Facility Instrumentation

Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth

Incidence of Upward Lightning Triggered by Nearby Lightning: A Monte Carlo Simulation

BCG hydrogel promotes CTSS-mediated antigen processing and presentation, thereby suppressing metastasis and prolonging survival in melanoma

Augmenting the performance of impoverished sensor networks using machine learning and time reversal: Application to lightning nowcasting and location

Immunosuppressive roles of Activin-A in melanoma and characterization of its precursor cleavage

Comment on “Straight lightning as a signature of macroscopic dark matter”

TGFBI modulates tumour hypoxia and promotes breast cancer metastasis

Roles of Epigenetic Dysregulation in Cancer Progression and Metastasis

Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation

Numerical and Experimental Validation of Electromagnetic Time Reversal for Geolocation of Lightning Strikes

The Geometry and Charge of the Streamer Bursts Generated by Lightning Rods under the Influence of High Electric Fields