A LIGHTning Strike to the Metastatic Niche

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Publications associées (32)

Impact of Frequency-Dependent Soil Models on Grounding System Performance for Direct and Indirect Lightning Strikes

Farhad Rachidi-Haeri

The goal of this article is to investigate the effect of frequency-dependent soil models on the performance of grounding electrodes subjected to lightning strikes. Several soil models are examined while accounting for the variation of soil resistivity and ...

2021

The laser lightning rod project

Farhad Rachidi-Haeri, Marcos Rubinstein, Jean-Pierre Wolf, Pierre Walch, Mohammad Azadifar, Clemens Herkommer, Amirhossein Mostajabi, Thomas Produit, Antonio Sunjerga

Lightning is highly destructive due to its high power density and unpredictable character. Directing lightning away would allow to protect sensitive sites from its direct and indirect impacts (electromagnetic perturbations). Up to now, lasers have been una ...

2021

Lightning to tall structures: Characterization, Modeling and Protection

Antonio Sunjerga

Lightning physics is highly multidisciplinary, involving areas such as plasma physics, electrical engineering, meteorology, thermodynamics and particle physics. Upward lightning is a special type of lightning initiated from tall structures that has attract ...

EPFL2021

Säntis Lightning Research Facility Instrumentation

Farhad Rachidi-Haeri, Marcos Rubinstein, Abraham Rubinstein, Davide Pavanello, Mario Paolone, David Smith, Carlos Alberto Romero Romero, Mohammad Azadifar, Amirhossein Mostajabi, Antonio Sunjerga

The Säntis Tower was instrumented in May 2010 to measure currents of lightning discharges striking the tower. Since then the system has been recurrently updated and expanded. Currently, data associated with lightning strikes to the tower are collected at f ...

2021

Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice

Lijing Xin, Cristina Ramona Cudalbu, Mario Gaetano Lepore, Marta Lai

The invasive behavior of glioblastoma, the most aggressive primary brain tumor, is considered highly relevant for tumor recurrence. However, the invasion zone is difficult to visualize by Magnetic Resonance Imaging (MRI) and is protected by the blood brain ...

2021

Incidence of Upward Lightning Triggered by Nearby Lightning: A Monte Carlo Simulation

Farhad Rachidi-Haeri, Marcos Rubinstein, Antonio Sunjerga

Upward lightning is the dominant type of lightning discharge to tall structures. It has been observed that a significant number of these upward flashes are initiated by nearby lightning activity. The aim of this study is to estimate the incidence of upward ...

2021

Augmenting the performance of impoverished sensor networks using machine learning and time reversal: Application to lightning nowcasting and location

Amirhossein Mostajabi

Lightning is formed in the atmosphere through the combination of intricate dynamic and microphysical processes. Mainly due to this complexity, attempts to solve the important problem of lightning prediction have generally failed to yield accurate results. ...

EPFL2021

TGFBI modulates tumour hypoxia and promotes breast cancer metastasis

Albert Santamaria Martinez

Breast cancer metastasis is a complex process that depends not only on intrinsic characteristics of metastatic stem cells, but also on the particular microenvironment that supports their growth and modulates the plasticity of the system. In search for micr ...

2020

Roles of Epigenetic Dysregulation in Cancer Progression and Metastasis

Mohammad Sadegh Saghafinia

Nearly all the cells of an organism share the same DNA sequence or genome, and yet they show different phenotypes and carry out different functions. This diversity is made possible by a verity of molecular modifications acting on the DNA sequence that coll ...

EPFL2020

Numerical and Experimental Validation of Electromagnetic Time Reversal for Geolocation of Lightning Strikes

Farhad Rachidi-Haeri, Marcos Rubinstein, Mohammad Azadifar, Hamidreza Karami, Amirhossein Mostajabi

We implement an electromagnetic time reversal technique (EMTR) to locate lightning return strokes. The two-dimensional finite difference time domain is employed to simulate the EMTR process in both, the forward-time and the backward-time phases. Scatterers ...

2020

Enhanced Phenotype Definition for Precision Isolation of Precursor Exhausted Tumor-Infiltrating CD8 T Cells

Pedro Romero, Amaia Martinez Usatorre

In the context of adoptive T cell transfer (ACT) for cancer treatment, it is crucial to generate in vitro large amounts of tumor-specific CD8 T cells with high potential to persist in vivo. PD-1, Tim3, and CD39 have been proposed as markers of tumor-specif ...

2020

Targeting the oncogenic signaling of the transcription factor STAT3 with potent and selective monobody inhibitors

Grégory La Sala

Many targeted cancer therapies fail to improve the overall survival of patients. Limitations involve low drug selectivity and the rapid development of resistance. Moreover, the majority of oncogenic drivers presently remain considered as undruggable as th ...

EPFL2020

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