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A LIGHTning Strike to the Metastatic Niche

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Direct In Vivo Activation of T Cells with Nanosized Immunofilaments Inhibits Tumor Growth and Metastasis

Bart Deplancke, Guido Van Mierlo, Jorieke Weiden

Adoptive T cell therapyhas successfully been implementedfor thetreatment of cancer. Nevertheless, ex vivo expansion of T cells byartificial antigen-presenting cells (aAPCs) remains cumbersome andcan compromise T cell functionality, thereby limiting their t ...

AMER CHEMICAL SOC2023

Laser-guided lightning

Farhad Rachidi-Haeri, Marcos Rubinstein, Antonio Sunjerga, Amirhossein Mostajabi

Lightning discharges between charged clouds and the Earth’s surface are responsible for considerable damages and casualties. It is therefore important to develop better protection methods in addition to the traditional Franklin rod. Here we present the fir ...

Nature Publishing Group2023

Impact of Frequency-Dependent Soil Models on Grounding System Performance for Direct and Indirect Lightning Strikes

Farhad Rachidi-Haeri

The goal of this article is to investigate the effect of frequency-dependent soil models on the performance of grounding electrodes subjected to lightning strikes. Several soil models are examined while accounting for the variation of soil resistivity and ...

2021

The laser lightning rod project

Farhad Rachidi-Haeri, Marcos Rubinstein, Mohammad Azadifar, Antonio Sunjerga, Amirhossein Mostajabi

Lightning is highly destructive due to its high power density and unpredictable character. Directing lightning away would allow to protect sensitive sites from its direct and indirect impacts (electromagnetic perturbations). Up to now, lasers have been una ...

EDP Sciences2021

Lightning interaction with the ionosphere

Farhad Rachidi-Haeri, Marcos Rubinstein

Lightning discharges, including cloud-to-ground (CG) and intracloud (IC) lightning, are known to emit electromagnetic pulses (EMPs) in a wide frequency band ranging from few Hz up to hundreds MHz [1]. During the breakdown and ionization processes (mostly f ...

IET2023

Lightning Nowcasting Using Solely Lightning Data

Farhad Rachidi-Haeri, Marcos Rubinstein, Amirhossein Mostajabi, Seyed Mohammad Ehsan Mansouri Tehrani

Lightning is directly or indirectly responsible for significant human casualties and property damage worldwide. A timely prediction of its occurrence can enable authorities and the public to take necessary precautionary actions resulting in diminishing the ...

MDPI2023

Lightning to tall structures: Characterization, Modeling and Protection

Antonio Sunjerga

Lightning physics is highly multidisciplinary, involving areas such as plasma physics, electrical engineering, meteorology, thermodynamics and particle physics. Upward lightning is a special type of lightning initiated from tall structures that has attract ...

EPFL2021

Aberrant hyperexpression of the RNA binding protein FMRP in tumors mediates immune evasion

Douglas Hanahan, Nadine Fournier, Mélanie Louise Tichet, Krisztian Homicsko, Agnieszka Alicja Chryplewicz, Mohammad Sadegh Saghafinia, Yuqing Xie, Dalya Ataca, Qiqun Zeng, Jeremy Gilles Louis Guillot, Simge Yücel

Many human cancers manifest the capability to circumvent attack by the adaptive immune system. In this work, we identified a component of immune evasion that involves frequent up-regulation of fragile X mental retardation protein (FMRP) in solid tumors. FM ...

American Association for the Advancement of Science2022

Säntis Lightning Research Facility Instrumentation

Mario Paolone, Farhad Rachidi-Haeri, Marcos Rubinstein, Davide Pavanello, Mohammad Azadifar, Antonio Sunjerga, Amirhossein Mostajabi, Abraham Rubinstein, Carlos Alberto Romero Romero

The Säntis Tower was instrumented in May 2010 to measure currents of lightning discharges striking the tower. Since then the system has been recurrently updated and expanded. Currently, data associated with lightning strikes to the tower are collected at f ...

2021

Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth

Michele De Palma, Mauro Delorenzi, Mario Leonardo Squadrito, Nadine Fournier, Sina Nassiri

Stem and progenitor cells residing in the intestinal crypts drive the majority of colorectal cancers (CRCs), yet vascular contribution to this niche remains largely unexplored. Vascular endothelial growth factor A (VEGFA) is a key driver of physiological a ...

Springernature2022

Incidence of Upward Lightning Triggered by Nearby Lightning: A Monte Carlo Simulation

Farhad Rachidi-Haeri, Marcos Rubinstein, Antonio Sunjerga

Upward lightning is the dominant type of lightning discharge to tall structures. It has been observed that a significant number of these upward flashes are initiated by nearby lightning activity. The aim of this study is to estimate the incidence of upward ...

2021

BCG hydrogel promotes CTSS-mediated antigen processing and presentation, thereby suppressing metastasis and prolonging survival in melanoma

Li Tang, Bing Feng

Background The use of intralesional Mycobacterium bovis BCG (intralesional live BCG) for the treatment of metastatic melanoma resulted in regression of directly injected, and occasionally of distal lesions. However, intralesional-BCG is less effective in p ...

BMJ PUBLISHING GROUP2022

Augmenting the performance of impoverished sensor networks using machine learning and time reversal: Application to lightning nowcasting and location

Amirhossein Mostajabi

Lightning is formed in the atmosphere through the combination of intricate dynamic and microphysical processes. Mainly due to this complexity, attempts to solve the important problem of lightning prediction have generally failed to yield accurate results. ...

EPFL2021

Immunosuppressive roles of Activin-A in melanoma and characterization of its precursor cleavage

Katarina Pinjusic

Activin-A, a transforming growth factor ê µ family member, is a pleiotropic cytokine with diverse functions in development, fertility, adult tissue homeostasis, and aging. Accordingly, deregulation of Activin-A signaling has been associated with many patho ...

EPFL2022

Comment on “Straight lightning as a signature of macroscopic dark matter”

Farhad Rachidi-Haeri, Marcos Rubinstein

In the discussed paper [N. Starkman, H. Winch, J. S. Sidhu, and G. Starkman, Straight lightning as a signature of macroscopic dark matter, Phys. Rev. D 103, 063024 (2021)], the authors have made several assumptions and statements concerning the initiation ...

2022

TGFBI modulates tumour hypoxia and promotes breast cancer metastasis

Albert Santamaria Martinez

Breast cancer metastasis is a complex process that depends not only on intrinsic characteristics of metastatic stem cells, but also on the particular microenvironment that supports their growth and modulates the plasticity of the system. In search for micr ...

2020

Roles of Epigenetic Dysregulation in Cancer Progression and Metastasis

Mohammad Sadegh Saghafinia

Nearly all the cells of an organism share the same DNA sequence or genome, and yet they show different phenotypes and carry out different functions. This diversity is made possible by a verity of molecular modifications acting on the DNA sequence that coll ...

EPFL2020

Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation

Andrea Ablasser

Solid cancers exhibit a dynamic balance between cell death and proliferation ensuring continuous tumour maintenance and growth(1,2). Increasing evidence links enhanced cancer cell apoptosis to paracrine activation of cells in the tumour microenvironment in ...

NATURE PORTFOLIO2022

Numerical and Experimental Validation of Electromagnetic Time Reversal for Geolocation of Lightning Strikes

Farhad Rachidi-Haeri, Marcos Rubinstein, Mohammad Azadifar, Amirhossein Mostajabi, Hamidreza Karami

We implement an electromagnetic time reversal technique (EMTR) to locate lightning return strokes. The two-dimensional finite difference time domain is employed to simulate the EMTR process in both, the forward-time and the backward-time phases. Scatterers ...

2020

The Geometry and Charge of the Streamer Bursts Generated by Lightning Rods under the Influence of High Electric Fields

Farhad Rachidi-Haeri, Marcos Rubinstein

The streamer bursts generated during the initiation and propagation of leaders play an important role in the creation and maintenance of hot discharge channels in air. The most important parameters related to streamer bursts in this respect are the length ...

2022