Optical measurement of cell membrane tension

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Publications associées (32)

Water as a contrast agent for imaging interfacial structure and ion transport in giant vesicles

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Hydrated lipid bilayer membranes and their asymmetry play a fundamental role in living cells by maintaining and regulating concentration gradients between cells, their environment, and their compartments. They achieve this not only through various channels ...

EPFL2022

Using Machine Learning to Predict Mortality for COVID-19 Patients on Day 0 in the ICU

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Rationale: Given the expanding number of COVID-19 cases and the potential for new waves of infection, there is an urgent need for early prediction of the severity of the disease in intensive care unit (ICU) patients to optimize treatment strategies.Objecti ...

FRONTIERS MEDIA SA2022

Second harmonic scattering of water in a biological context

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Water is one of the most abundant molecules in the universe. It forms a hydrogen bond network with unique structure and dynamics. Hydrogen bonding is highly relevant to many biological processes including membrane formation, protein folding, adsorption, an ...

EPFL2022

Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function

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Interaction with microenvironmental factors is crucial for the regulation of hematopoietic stem cell (HSC) function. Stroma derived factor (SDF)-1 alpha supports HSCs in the quiescent state and is central to the homing of transplanted HSCs. Here, we show t ...

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On the Capability of Wall-Modeled Large Eddy Simulations to Predict Particle Dispersion in Complex Turbulent Flows

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Predicting particle transport in turbulent flows has a plethora of applications, some of which are: the transport of atmospheric aerosols, the deposition of blood cells in the arteries of human bodies and the atomization of fuel droplets in combustion cham ...

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Engineering synthetic adhesins for biophysical investigation and rewiring of host-microbe interactions

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Host attachment is often a critical step in the onset of pathogenesis. To attach to host cells, bacteria have evolved a range of adhesins that bind to specific receptors. Some of these adhesins have been thoroughly characterized using biochemical technique ...

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Ion-bridges and lipids drive aggregation of same-charge nanoparticles on lipid membranes

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The control of the aggregation of biomedical nanoparticles (NP) in physiological conditions is crucial as clustering may change completely the way they interact with the biological environment. Here we show that Au nanoparticles, functionalized by an anion ...

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Selective integrin targeting with DNA-based nanomaterials

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Targeting cells specific to type and state remains a challenge in developing effective therapies, sensitive diagnostics, also robust and versatile tissue engineering. A promising strategy is to focuses on improving the inherent selectivity of the targeting ...

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An increase of oxygen saturation within blood bags and metabolic dysregulation occur during storage of red blood cells (RBCs). It leads to the gradual exhaustion of RBC antioxidant protective system and, consequently, to a deleterious state of oxidative st ...

2021

Modelling the Intracellular Environment under Uncertainty, from Post-translational Modification to Metabolic Networks

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Modelling and analysis of biological systems is crucial in order to quantitatively explain and predict their behaviour. The importance of modelling in systems biology becomes even more evident when tackling complex, large systems. Approaches that rely on ...

EPFL2021

Passive and active ion permeation through lipid bilayers investigated by second harmonic water imaging

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Lipid membranes are complex and dynamic systems which are known to mediate signaling processes between cells and their environment. To do this multiple ion channels and pumps are involved in controlling the in- and out-flux of various ions (K+, Na+, Mg2+, ...

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Specific Protein-Membrane Interactions Promote Packaging of Metallo-beta-Lactamases into Outer Membrane Vesicles

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Outer membrane vesicles (OMVs) act as carriers of bacterial products such as plasmids and resistance determinants, including metallo-beta-lactamases. The lipidated, membrane-anchored metallo-beta-lactamase NDM-1 can be detected in Gram-negative OMVs. The s ...

AMER SOC MICROBIOLOGY2021

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