Publications de Claudia Kathe | EPFL Graph Search

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Neural control of movement cannot be fully understood without careful consideration of interactions between the neural and biomechanical components. Recent advancements in mouse molecular genetics allow for the identification and manipulation of constituen ...

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival(1-3), impairs neurological recovery(4,5), increases the risk of cardiovascular disease(6,7), and reduces quality of life(8,9). Haemodynamic instability in this context is due ...

Axon regeneration can be induced across anatomically complete spinal cord injury (SCI), but robust functional restoration has been elusive. Whether restoring neurological functions requires directed regeneration of axons from specific neuronal subpopulatio ...

Next-generation bioelectronic implants require miniaturization, durability, and long-term functionality. Thin film encapsulations, prepared with inorganic or hybrid organic/inorganic designs, are essential for ensuring protection, low water permeation, ada ...

Optoelectronic systems can exert precise control over targeted neurons and pathways throughout the brain in untethered animals, but similar technologies for the spinal cord are not well established. In the present study, we describe a system for ultrafast, ...

A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed to identify brain regions that steer the recovery of walking after i ...

Unilateral or bilateral corticospinal tract injury in the medullary pyramids in adult rats causes anatomical and physiological changes in proprioceptive neurons projecting to the cervical spinal cord accompanied by hyperreflexia and abnormal behavioural mo ...

A spinal cord injury interrupts pathways from the brain and brainstem that project to the lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural electrical stimulation (EES) of the lumbar spinal cord(1-3) applied during neurore ...

After a spinal cord injury, axons fail to regenerate in the adult mammalian central nervous system, leading to permanent deficits in sensory and motor functions. Increasing neuronal activity after an injury using electrical stimulation or rehabilitation ca ...

The cell types affected by biological perturbations in complex tissues are uncovered by single-cell analysis. ...

Here, we introduce the Tabulae Paralytica—a compilation of four atlases of spinal cord injury (SCI) comprising a single-nucleus transcriptome atlas of half a million cells, a multiome atlas pairing transcriptomic and epigenomic measurements within the same ...

After spinal cord injury, tissue distal to the lesion contains undamaged cells that could support or augment recovery. Targeting these cells requires a clearer understanding of their injury responses and capacity for repair. Here, we use single nucleus RNA ...

The authors summarize changes in circuits after spinal cord injury and current strategies to target these circuits in order to improve recovery, but also advocate for new concepts of reorganizing circuits informed by multi-omic single-cell atlases. ...

Claudia Kathe

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A Whole-Body Musculoskeletal Model of the Mouse

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Recovery of walking after paralysis by regenerating characterized neurons to their natural target region

Magnesium Test: Universal and Ultra-Sensitive Method for Measuring Reliability of Thin-Film-Encapsulated Bioelectronic Implants in Physiological Environment

Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice

Hypothalamic deep brain stimulation augments walking after spinal cord injury

RNA sequencing dataset describing transcriptional changes in cervical dorsal root ganglia after bilateral pyramidotomy and forelimb intramuscular gene therapy with an adeno-associated viral vector encoding human neurotrophin-3

The neurons that restore walking after paralysis

Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models

Cell type prioritization in single-cell data

Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica

Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons

Natural and targeted circuit reorganization after spinal cord injury

Transcriptional Dynamics Of Neurorehabilitation In Spinal Cord Injury At Single-Nucleus Resolution