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Marco Capogrosso

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Publications associées (38)

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics

Tomislav Milekovic, Jérôme Gandar, Grégoire Courtine, Nikolaus Wenger, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Natalia Pavlova, Fabien Bertrand Paul Wagner, Polina Shkorbatova, Jocelyne Bloch

Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait kinematics are powerful methods for the study of locomotion and the improvement of motor control after injury or in neurological disorders. Here, we describe equipmen ...

2018

A sensory information compliant spinal cord stimulation system for the rehabilitation of motor functions

Silvestro Micera, Grégoire Courtine, Emanuele Formento, Marco Capogrosso, Karen Minassian

The present invention refers to a system for stimulation of the spinal cord for the rehabilitation of motor function in subjects with spinal cord injury or other motor disorders. Said system comprises a programmable implantable pulse generator (IPG), opera ...

2018

Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model

Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Fabien Bertrand Paul Wagner, Beatrice Barra, Jocelyne Bloch, Xiaoyang Kang

Long-term biointegration of man-made neural interfaces is influenced by the mechanical properties of the implant materials. Substantial experimental work currently aims at replacing conventional hard implant materials with soft alternatives that can favour ...

IEEE2018

Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord

Jérôme Gandar, Stéphanie Lacour, Grégoire Courtine, Nikolaus Wenger, Ivan Rusev Minev, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Polina Shkorbatova, Nathan Antoine Greiner

Objective. We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to the spinal cord. These stimulations restored locomotion in animal models of paralysis. Soft interfaces can be placed either below or abo ...

2018

Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury

Camille Georgette Marie Le Goff-Mignardot, Silvestro Micera, Grégoire Courtine, Emanuele Formento, Marco Capogrosso, Jean-Baptiste Mignardot, Fabien Bertrand Paul Wagner, Andreas Rowald, Karen Minassian, Jocelyne Bloch

Epidural electrical stimulation (EES) of the spinal cord restores locomotion in animal models of spinal cord injury but is less effective in humans. Here we hypothesized that this interspecies discrepancy is due to interference between EES and propriocepti ...

2018

System for selective spatiotemporal stimulation of the spinal cord

Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Marco Capogrosso, Jocelyne Bloch

The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject ...

2017

Long-term usability and bio-integration of polyimide-based intraneural stimulating electrodes

Sophie Marie Marthe Wurth, Jérôme Gandar, Nawal Noëlle Kinany, Silvestro Micera, Grégoire Courtine, Stanisa Raspopovic, Quentin Barraud, Alessandra Piersigilli, Marco Capogrosso, Natalia Pavlova, Jacopo Rigosa, Polina Shkorbatova

Stimulation of peripheral nerves has transiently restored lost sensation and has the potential to alleviate motor deficits. However, incomplete characterization of the long-term usability and bio-integration of intra-neural implants has restricted their us ...

Elsevier Sci Ltd2017

A Computational Framework for the Design of Spinal Neuroprostheses

Silvestro Micera, Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch

Severe Spinal Cord Injury (SCI) alters the communication between supra-spinal centers and the sensorimotor networks coordinating limb movements, which are usually located below the injury. Epidural electrical stimulation of lumbar segments has shown the ab ...

Springer International Publishing Ag2017

A multidirectional gravity-assist algorithm that enhances locomotor control in patients with stroke or spinal cord injury

Auke Ijspeert, Grégoire Courtine, Selin Anil, Joachim von Zitzewitz, Rubia van den Brand, Marco Capogrosso, Jean-Baptiste Mignardot, Nicolas Francis Fumeaux, Jessica Lanini, Jocelyne Bloch

Gait recovery after neurological disorders requires remastering the interplay between body mechanics and gravitational forces. Despite the importance of gravity-dependent gait interactions and active participation for promoting this learning, these essenti ...

Amer Assoc Advancement Science2017

A brain-spine interface alleviating gait deficits after spinal cord injury in primates

Tomislav Milekovic, Jérôme Gandar, Silvestro Micera, Grégoire Courtine, Quentin Barraud, Simone Ellen Joze Duis, Eduardo Martin Moraud, Marco Capogrosso, David Allenson Borton, Jean-Baptiste Mignardot, Fabien Bertrand Paul Wagner, Elodie Rey, Jocelyne Bloch

Spinal cord injury disrupts the communication between the brain and the spinal circuits that orchestrate movement. To bypass the lesion, brain-computer interfaces(1-3) have directly linked cortical activity to electrical stimulation of muscles, and have th ...

Nature Publishing Group2016

Bidirectional Limb Neuro-Prosthesis

Silvestro Micera, Stanisa Raspopovic, Marco Bonizzato, Marco Capogrosso, Francesco Maria Petrini

Integrated closed-loop real-time limb neuro-prosthetic system comprising an artificial limb, a microprocessor, sensors, a signal conditioner, a stimulator, at least one EMG electrode and at least one sensory feedback electrode, characterized by the fact th ...

2016

Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury

Léonie Asboth, Jérôme Gandar, Stéphanie Lacour, Arthur Edouard Hirsch, Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Ivan Rusev Minev, Rubia van den Brand, Quentin Barraud, Simone Ellen Joze Duis, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Natalia Pavlova, Julie Kreider, Laetitia Danielle Philippine Baud, Andrea Mortera, Jocelyne Bloch

Electrical neuromodulation of lumbar segments improves motor control after spinal cord injury in animal models and humans. However, the physiological principles underlying the effect of this intervention remain poorly understood, which has limited the ther ...

Nature Publishing Group2016

Neuroprosthetic technologies to augment the impact of neurorehabilitation after spinal cord injury

Silvestro Micera, Grégoire Courtine, Joachim von Zitzewitz, Rubia van den Brand, Eduardo Martin Moraud, Marco Capogrosso, Jean-Baptiste Mignardot, Nicolas Francis Fumeaux, Fabien Bertrand Paul Wagner, Jocelyne Bloch

Spinal cord injury leads to a range of disabilities, including limitations in locomotor activity, that seriously diminish the patients’ autonomy and quality of life. Electrochemical neuromodulation therapies, robot-assisted rehabilitation and willpower-bas ...

2015

Biomaterials. Electronic dura mater for long-term multimodal neural interfaces

Tomislav Milekovic, Léonie Asboth, Jérôme Gandar, Nicolas Vachicouras, Stéphanie Lacour, Arthur Edouard Hirsch, Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Ivan Rusev Minev, Quentin Barraud, Simone Ellen Joze Duis, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Natalia Pavlova

The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protectiv ...

American Association for the Advancement of Science2015

Chronic multichannel neural recordings from soft regenerative microchannel electrodes during gait

Sophie Marie Marthe Wurth, Shreya Narasimhan, Stéphanie Lacour, Katherine Marie Musick, Silvestro Micera, Marco Capogrosso, Jacopo Rigosa

Reliably interfacing a nerve with an electrode array is one of the approaches to restore motor and sensory functions after an injury to the peripheral nerve. Accomplishing this with current technologies is challenging as the electrode-neuron interface ofte ...

Nature Publishing Group2015

Restoring Natural Sensory Feedback in Real-Time Bidirectional Hand Prostheses

Silvestro Micera, Stanisa Raspopovic, Marco Bonizzato, Marco Capogrosso, Francesco Maria Petrini, Jacopo Rigosa

Hand loss is a highly disabling event that markedly affects the quality of life. To achieve a close to natural replacement for the lost hand, the user should be provided with the rich sensations that we naturally perceive when grasping or manipulating an o ...

American Association for the Advancement of Science2014

A Computational Model for Epidural Electrical Stimulation of Spinal Sensorimotor Circuits

Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Stanisa Raspopovic, Janine Beauparlant, Pavel Musienko, Marco Capogrosso

Epidural electrical stimulation (EES) of lumbosacral segments can restore a range of movements after spinal cord injury. However, the mechanisms and neural structures through which EES facilitates movement execution remain unclear. Here, we designed a comp ...

Society for Neuroscience2013

Correction to : "Experimental Validation of a Hybrid Computational Model for Selective Stimulation Using Transverse Intrafascicular Multichannel Electrodes"

Silvestro Micera, Stanisa Raspopovic, Marco Capogrosso

Institute of Electrical and Electronics Engineers2012

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