Publications de Grégoire Courtine

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Differential expression analysis of single-cell transcriptomics allows scientists to dissect cell-type-specific responses to biological perturbations. Here, the authors show that many commonly used methods are biased and can produce false discoveries. ...

Here, we introduce the Tabulae Paralytica—a compilation of four atlases of spinal cord injury (SCI) comprising a single-nucleus transcriptome atlas of half a million cells, a multiome atlas pairing transcriptomic and epigenomic measurements within the same ...

The present invention relates system for planning and/or providing neuromodulation (10), especially neurostimulation, comprising - a neurostimulator (24) comprising a least one electrode (22), - functional mapping module (38) configured and arranged such t ...

Long-term biointegration of man-made neural interfaces is influenced by the mechanical properties of the implant materials. Substantial experimental work currently aims at replacing conventional hard implant materials with soft alternatives that can favour ...

People with late-stage Parkinson's disease (PD) often suffer from debilitating locomotor deficits that are resistant to currently available therapies. To alleviate these deficits, we developed a neuroprosthesis operating in closed loop that targets the dor ...

A spinal cord injury interrupts the communication between the brain and the region of the spinal cord that produces walking, leading to paralysis(1,2). Here, we restored this communication with a digital bridge between the brain and spinal cord that enable ...

The present invention relates to a neuromodulation/neurostimulation system for supporting and/or controlling a function of t he respiratory system of a patient, said function comprising a plurality of phases each involving one or more muscles. The system c ...

After spinal cord injury, tissue distal to the lesion contains undamaged cells that could support or augment recovery. Targeting these cells requires a clearer understanding of their injury responses and capacity for repair. Here, we use single nucleus RNA ...

IMPORTANCE A growing number of neurologic treatments rely on neural implants capable of delivering electrical and chemical stimulation to targeted regions of the central nervous system for extended periods. OBJECTIVE To assess the potential of a novel clas ...

Epidural electrical stimulation (EES) of the spinal cord restores locomotion in animal models of spinal cord injury but is less effective in humans. Here we hypothesized that this interspecies discrepancy is due to interference between EES and propriocepti ...

The authors summarize changes in circuits after spinal cord injury and current strategies to target these circuits in order to improve recovery, but also advocate for new concepts of reorganizing circuits informed by multi-omic single-cell atlases. ...

The present invention relates to systems and methods for planning and/or providing neuromodulation One example system includesa stimulation related basic data storage module for storing stimulation related basic data,a stimulation related response data sto ...

Differential accessibility (DA) analysis of single-cell epigenomics data enables the discovery of regulatory programs that establish cell type identity and steer responses to physiological and pathophysiological perturbations. While many statistical method ...

Biological and engineering strategies for neural repair and recovery from neurotrauma continue to emerge at a rapid pace. Until recently, studies of the impact of neurotrauma and repair strategies on the reorganization of the central nervous system have fo ...

Neurological damage caused by spinal cord injury in humans has been observed for over three thousand years and impacts the lives of several hundred thousand people worldwide. Despite this prevalence and its associated consequences, there is no treatment to ...

The present invention and its embodiments propose a simple, unique, and scalable method for producing extremely long, highly uniform, and well-ordered micro- and nanoscale metallic glasses via thermal drawing the method comprising at least the steps of pre ...

Grégoire Courtine

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Confronting false discoveries in single-cell differential expression

Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica

System for planning and/or providing neuromodulation, especially neurostimulation

Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model

A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease

Walking naturally after spinal cord injury using a brain-spine interface

Neuromodulation/neurostimulation system for controlling a respiratory function

Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons

Electronic Dura Mater Meddling in the Central Nervous System

Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury

Brain–machine interface: closer to therapeutic reality?

Natural and targeted circuit reorganization after spinal cord injury

System for planning and/or providing neuromodulation

Best practices for differential accessibility analysis in single-cell epigenomics

Optogenetic Interrogation of Circuits Following Neurotrauma

Low-Dimensional Motor Cortex Dynamics Preserve Kinematics Information During Unconstrained Locomotion in Nonhuman Primates (vol

Domains Of Neural Control Of Walking In Human Spinal Cord Injury

Engineering spinal cord repair

Ultralong, complexly structured micro- and nanoscale metallic glasses and fibers

A spinal neuroprosthesis against locomotor deficits in Parkinson's disease