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Grégoire Courtine

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Publications associées (146)

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Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury

Silvestro Micera, Grégoire Courtine, Stanisa Raspopovic, Eduardo Martin Moraud, Nikolaus Wenger, Marco Bonizzato, Pavel Musienko, John Francis Di Giovanna

Neuromodulation of spinal sensorimotor circuits improves motor control in animal models and humans with spinal cord injury. With common neuromodulation devices, electrical stimulation parameters are tuned manually and remain constant during movement. We de ...

American Association for the Advancement of Science2014

Apparatus to apply forces in a three-dimensional space

Grégoire Courtine, Joachim von Zitzewitz

The present invention relates to a robotic system useful to unload an object/person from its weight. The robotic system is useful in locomotor rehabilitation programs and allows the manipulation of forces in a three-dimensional space with far lower actuato ...

2017

Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

Grégoire Courtine, Bernard Schneider, Quentin Barraud, Léonie Asboth, Mark Andrew Anderson, Lucia Florinda Friedli Wittler, Laetitia Danielle Philippine Baud, Janine Beauparlant, Galyna Pidpruzhnykova, Selin Anil, Julie Kreider, Elodie Rey

Severe spinal cord contusions interrupt nearly all brain projections to lumbar circuits producing leg movement. Failure of these projections to reorganize leads to permanent paralysis. Here we modeled these injuries in rodents. A severe contusion abolished ...

2018

Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys

Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Giuseppe Schiavone, Florian Dylan Fallegger, Quentin Barraud, Tomislav Milekovic, Katia Galan, Nicholas David James

Regaining arm control is a top priority for people with paralysis. Unfortunately, the complexity of the neural mechanisms underlying arm control has limited the effectiveness of neurotechnology approaches. Here, we exploited the neural function of survivin ...

NATURE PORTFOLIO2022

A digital bridge between brain and spinal cord restores walking after paralysis

Grégoire Courtine, Jocelyne Bloch

Spinal-cord injury interrupts communication between the brain and spinal cord, leading to paralysis. An implant that decodes the brain signals that control movements and drives electrical stimulation of the spinal cord re-establishes this communication, en ...

NATURE PORTFOLIO2023

System for closed loop control of autonomic function

Grégoire Courtine, Jordan Squair

A neuromodulation system (10,110) is disclosed, especially a neurostimulation system (10,110), for treating a patient, especially for enhancing at least one autonomous function such a blood circulation and/or respiration, wherein the system comprises • - a ...

2020

Soft Printable Electrode Coating for Neural Interfaces

Stéphanie Lacour, Grégoire Courtine, Elvira Pirondini, Florian Dylan Fallegger, Quentin Barraud, Arnaud Bichat, Michael Shur

The mechanical mismatch between implantable interfaces and neural tissues may be reduced by employing soft polymeric materials. Here, we report on a simple strategy to prepare and pattern a soft electrode coating of neural interfacing devices based on a sc ...

2020

Neuroprosthetic technologies to augment the impact of neurorehabilitation after spinal cord injury

Silvestro Micera, Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Joachim von Zitzewitz, Nicolas Francis Fumeaux, Marco Capogrosso, Fabien Bertrand Paul Wagner, Jean-Baptiste Mignardot

Spinal cord injury leads to a range of disabilities, including limitations in locomotor activity, that seriously diminish the patients’ autonomy and quality of life. Electrochemical neuromodulation therapies, robot-assisted rehabilitation and willpower-bas ...

2015

A system for planning and/or providing neuromodulation

Grégoire Courtine, Marco Capogrosso, Fabien Bertrand Paul Wagner, Vincent Delattre, Karen Minassian

The present invention relates to a system for planning and/or providing neuromodulation (10), especially neurostimulation, comprising: - first data input module (26) for stimulation related basic data, - a stimulation related basic data storage module (28) ...

2019

Cell type prioritization in single-cell data

Grégoire Courtine, Gioele La Manno, Quentin Barraud, Jordan Squair, Claudia Kathe, Matthieu Pierre Gautier, Mark Andrew Anderson, Thomas Haynes Hutson, Michael Alexander Skinnider, Marco Milano

The cell types affected by biological perturbations in complex tissues are uncovered by single-cell analysis. ...

NATURE PUBLISHING GROUP2021

Investigation of neural and biomechanical impairments leading to pathological toe and heel gaits using neuromusculoskeletal modelling

Auke Ijspeert, Grégoire Courtine, Andrea Di Russo, Dimitar Yuriev Stanev, Alice Julie Bruel

This study investigates the pathological toe and heel gaits seen in human locomotion using neuromusculoskeletal modelling and simulation. In particular, it aims to investigate potential cause-effect relationships between biomechanical or neural impairments ...

WILEY2022

Implanted System for Orthostatic Hypotension in Multiple-System Atrophy

Grégoire Courtine, Jocelyne Bloch, Jordan Squair, Léonie Asboth, Robin Jonathan Demesmaeker, Grégory Didier Dumont, Nicolas Hankov, Sergio Daniel Hernandez, Suje Amir

Orthostatic hypotension is a cardinal feature of multiple-system atrophy. The upright posture provokes syncopal episodes that prevent patients from standing and walking for more than brief periods. We implanted a system to restore regulation of blood press ...

MASSACHUSETTS MEDICAL SOC2022

Personalized neuroprosthetics

Silvestro Micera, José del Rocio Millán Ruiz, Grégoire Courtine, David Allenson Borton

Decades of technological developments have populated the field of neuroprosthetics with myriad replacement strategies, neuromodulation therapies, and rehabilitation procedures to improve the quality of life for individuals with neuromotor disorders. Despit ...

American Association for the Advancement of Science2013

System for micturition control in a mammal with bladder disfunction

Grégoire Courtine, Jocelyne Bloch, Jordan Squair, Loïs Thomas Romain Mahe

The present invention relates to a neuromodulation/neurostimulation system (10) for stimulating at least one neuronal circuitry responsible for micturition control in a mammal with bladder disfunction, especially for bladder relaxation and/or for bladder v ...

2024

Diagnosis and management of orthostatic hypotension in synucleinopathies Diagnostic et prise en charge des hypotensions orthostatiques en cas de synucléinopathies

Aasta Parin Gandhi, Grégoire Courtine

Synucleinopathies are frequently associated with non-motor symptoms such as orthostatic hypotension, which directly impacts patients’ quality of life and requires effective management by general practitioners and neurologists. This management involves drug ...

2025

Implantable blood pressure monitor

Grégoire Courtine, Jordan Squair

An implantable blood pressure monitor has two or more elements configured to wrap at least part way around a blood vessel. Changes in pressure within the blood vessel may be sensed by detecting movements of the elements or forces applied to the elements. A ...

2021

Recruitment of upper-limb motoneurons with epidural electrical stimulation of the cervical spinal cord

Stéphanie Lacour, Grégoire Courtine, Giuseppe Schiavone, Florian Dylan Fallegger, Nicholas David James, Henri Charles Alexandre Lorach, Simon Borgognon, Nathan Antoine Greiner

Epidural electrical stimulation (EES) of lumbosacral sensorimotor circuits improves leg motor control in animals and humans with spinal cord injury (SCI). Upper-limb motor control involves similar circuits, located in the cervical spinal cord, suggesting t ...

Nature Research2021

A brain-spine interface alleviating gait deficits after spinal cord injury in primates

Silvestro Micera, Grégoire Courtine, Jocelyne Bloch, Marco Capogrosso, Quentin Barraud, Eduardo Martin Moraud, Fabien Bertrand Paul Wagner, Jérôme Gandar, Jean-Baptiste Mignardot, Tomislav Milekovic, David Allenson Borton, Elodie Rey

Spinal cord injury disrupts the communication between the brain and the spinal circuits that orchestrate movement. To bypass the lesion, brain-computer interfaces(1-3) have directly linked cortical activity to electrical stimulation of muscles, and have th ...

Nature Publishing Group2016

Muscle Spindle Feedback Directs Locomotor Recovery and Circuit Reorganization after Spinal Cord Injury

Grégoire Courtine

Spinal cord injuries alter motor function by disconnecting neural circuits above and below the lesion, rendering sensory inputs a primary source of direct external drive to neuronal networks caudal to the injury. Here, we studied mice lacking functional mu ...

Elsevier2014

Neglected physical human-robot interaction may explain variable outcomes in gait neurorehabilitation research

Grégoire Courtine

During gait neurorehabilitation, many factors influence the quality of gait patterns, particularly the chosen body-weight support (BWS) device. Consequently, robotic BWS devices play a key role in gait rehabilitation of people with neurological disorders. ...

AMER ASSOC ADVANCEMENT SCIENCE2021