Recherche

Afficher tous les résultats pour

Accueil

Personne

Jacques Fellay

À propos
Confidentialité
Mentions légales

Graph Chatbot

Publications associées (191)

Genome-to-genome analysis of Epstein-Barr virus infection

Jacques Fellay, Christian Hammer

NATURE PUBLISHING GROUP2019

Rare variants in antiviral response genes drive severe viral respiratory infections in children

Samira Asgari, Jacques Fellay, Dylan Lawless

NATURE PUBLISHING GROUP2019

Gender medicine and oncology: report and consensus of an ESMO workshop

Jacques Fellay

Background: The importance of sex and gender as modulators of disease biology and treatment outcomes is well known in other disciplines of medicine, such as cardiology, but remains an undervalued issue in oncology. Considering the increasing evidence for t ...

OXFORD UNIV PRESS2019

Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

Jacques Fellay, Christian Axel Wandall Thorball, Alessandro Borghesi

The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population ...

Springer2019

HIV Transmission Chains Exhibit Greater HLA-B Homogeneity Than Randomly Expected

Jacques Fellay, Christian Axel Wandall Thorball

Background: HIV's capacity to escape immune recognition by human leukocyte antigen (HLA) is a core component of HIV pathogenesis. A better understanding of the distribution of HLA class I in HIV-infected patients would improve our knowledge of pathogenesis ...

LIPPINCOTT WILLIAMS & WILKINS2019

Adaptation of hepatitis C virus to interferon lambda polymorphism across multiple viral genotypes

Jacques Fellay, Nimisha Chaturvedi

Genetic polymorphism in the interferon lambda (IFN-lambda) region is associated with spontaneous clearance of hepatitis C virus (HCV) infection and response to interferon-based treatment. Here, we evaluate associations between IFN-l polymorphism and HCV va ...

2019

HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

Jacques Fellay, Christian Hammer, Daniel Sauter

Many viral pathogens target innate sensing cascades and/or cellular transcription factors to suppress antiviral immune responses. Here, we show that the accessory viral protein U (Vpu) of HIV-1 exerts broad immunosuppressive effects by inhibiting activatio ...

2019

HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control

Jacques Fellay, Paul Jack Mc Laren, Nimisha Chaturvedi

Genetic variation in the peptide-binding groove of the highly polymorphic HLA class I molecules has repeatedly been associated with HIV-1 control and progression to AIDS, accounting for up to 12% of the variation in HIV-1 set point viral load (spVL). This ...

National Academy of Sciences2019

Systems Biology in 874 Patients with Primary Sjogren's Syndrome Indicates the Predominant Role of Interferon Alpha Compared to Interferon Gamma, Its Association with Systemic Complications, and a New Aspect of the Genetic Contribution of HLA

Nicolas Meyer, Jacques Fellay, Christian Axel Wandall Thorball

WILEY2019

Human genetic determinants of chronic low-grade inflammation in the general population

Jacques Fellay, Flavia Aurelia Shoko Hodel

NATURE PUBLISHING GROUP2019

Human genomics of acute liver failure due to hepatitis B virus infection: An exome sequencing study in liver transplant recipients

Samira Asgari, Jacques Fellay, Christian Hammer, Petar Scepanovic, Nimisha Chaturvedi

Acute liver failure (ALF) or fulminant hepatitis is a rare, yet severe outcome of infection with hepatitis B virus (HBV) that carries a high mortality rate. The occurrence of a life-threatening condition upon infection with a prevalent virus in individuals ...

2019

Effect of Fc Receptor Genetic Diversity on HIV-1 Disease Pathogenesis

Jacques Fellay, Christian Axel Wandall Thorball

Fc receptor (FcR) genes collectively have copy number and allelic polymorphisms that have been implicated in multiple inflammatory and autoimmune diseases. This variation might also be involved in etiology of infectious diseases. The protective role of Fc- ...

2019

Visual masking deficits in schizophrenia: A view into the genetics of the disease through an endophenotype

Michael Herzog, Maya Roinishvili, Jacques Fellay, Flavia Aurelia Shoko Hodel

Schizophrenia is a chronic disorder determined by a complex mix of genetic and environmental factors. To better understand the contributions of human genetic variation to schizophrenia, we performed a genome-wide association study of a validated endophenot ...

2018

Interferon lambda 3/4 polymorphisms are associated with AIDS-related Kaposi's sarcoma

Patrick Taffe, Jacques Fellay

Background: Kaposi's sarcoma, the most common AIDS-related cancer, represents a major public concern in resource-limited countries. Single nucleotide polymorphisms within the Interferon lambda 3/4 region (IFNL3/4) determine the expression, function of IFNL ...

LIPPINCOTT WILLIAMS & WILKINS2018

Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD4+ T Cell Decline and Per-Parasite Pathogenicity

Gabriel Leventhal, Jacques Fellay

Pathogen strains may differ in virulence because they attain different loads in their hosts, or because they induce different disease-causing mechanisms independent of their load. In evolutionary ecology, the latter is referred to as" per-parasite pathogen ...

Oxford University Press2018

Page 7 sur 10

Jacques Fellay

Graph Chatbot

Genome-to-genome analysis of Epstein-Barr virus infection

Rare variants in antiviral response genes drive severe viral respiratory infections in children

Gender medicine and oncology: report and consensus of an ESMO workshop

Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

HIV Transmission Chains Exhibit Greater HLA-B Homogeneity Than Randomly Expected

Adaptation of hepatitis C virus to interferon lambda polymorphism across multiple viral genotypes

HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control

Systems Biology in 874 Patients with Primary Sjogren's Syndrome Indicates the Predominant Role of Interferon Alpha Compared to Interferon Gamma, Its Association with Systemic Complications, and a New Aspect of the Genetic Contribution of HLA

Human genetic determinants of chronic low-grade inflammation in the general population

Human genomics of acute liver failure due to hepatitis B virus infection: An exome sequencing study in liver transplant recipients

Effect of Fc Receptor Genetic Diversity on HIV-1 Disease Pathogenesis

Visual masking deficits in schizophrenia: A view into the genetics of the disease through an endophenotype

Interferon lambda 3/4 polymorphisms are associated with AIDS-related Kaposi's sarcoma

Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD4+ T Cell Decline and Per-Parasite Pathogenicity

Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines

Easy and accurate reconstruction of whole HIV genomes from short-read sequence data with shiver

Detection of novel astroviruses MLB1 and MLB2 in the sera of febrile Tanzanian children

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

Killer cell immunoglobulin–like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1