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Jacques Fellay

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Publications associées (191)

HLA Heterozygote Advantage against HIV-1 Is Driven by Quantitative and Qualitative Differences in HLA Allele-Specific Peptide Presentation

Jacques Fellay

Pathogen-mediated balancing selection is regarded as a key driver of host immunogenetic diversity. A hallmark for balancing selection in humans is the heterozygote advantage at genes of the human leukocyte antigen (HLA), resulting in improved HIV-1 control ...

OXFORD UNIV PRESS2020

Genome-to-genome analysis identifies an Asian-specific variant in the gene encoding NTCP that leads to specific HBV escape mutations during chronic infection

Jacques Fellay, Sina Rüeger, Zhi Ming Xu

SPRINGERNATURE2020

Using reference-fixed principal components to improve polygenic risk score prediction

Jacques Fellay, Olivier Noël Marie Naret

SPRINGERNATURE2020

Data protection and ethics requirements for multisite research with health data: a comparative examination of legislative governance frameworks and the role of data protection technologies

Jean-Pierre Hubaux, Jacques Fellay, Jean Louis Raisaro, Juan Ramón Troncoso-Pastoriza

Personalised medicine can improve both public and individual health by providing targeted preventative and therapeutic healthcare. However, patient health data must be shared between institutions and across jurisdictions for the benefits of personalised me ...

OXFORD UNIV PRESS2020

HLA tapasin independence: broader peptide repertoire and HIV control

Jacques Fellay

Human leukocyte antigen (HLA) class I allotypes vary in their ability to present peptides in the absence of tapasin, an essential component of the peptide loading complex. We quantified tapasin dependence of all allotypes that are common in European and Af ...

National Academy of Sciences2020

Impact of Genetic and Nongenetic Factors on Body Mass Index and Waist-Hip Ratio Change in HIV-Infected Individuals Initiating Antiretroviral Therapy

Thierry Buclin, Monia Guidi, Jacques Fellay, Christian Hammer, Christian Axel Wandall Thorball

Objective. There is limited data on abdominal obesity and the influence of genetics on weight change after ant iretroviral therapy (ART) initiation. We assessed body mass index (BMI) and waist hip ration (WHR) change over time in the Swiss HIV Cohort study ...

OXFORD UNIV PRESS INC2020

Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART

Jacques Fellay, Chenjie Wan

The HIV-1 reservoir is the major hurdle to curing HIV-1. However, the impact of the viral genome on the HIV-1 reservoir, i.e. its heritability, remains unknown. We investigate the heritability of the HIV-1 reservoir size and its long-term decay by analyzin ...

Nature Research2020

Human genomics of the humoral response against polyomaviruses

Jacques Fellay, Flavia Aurelia Shoko Hodel, Christian Hammer, Petar Scepanovic, Christian Axel Wandall Thorball, Zhi Ming Xu

SPRINGERNATURE2020

Host Genomics of the HIV-1 Reservoir Size and Its Decay Rate During Suppressive Antiretroviral Treatment

Jacques Fellay, Christian Axel Wandall Thorball, Alessandro Borghesi

Background: The primary hurdle for the eradication of HIV-1 is the establishment of a latent viral reservoir early after primary infection. Here, we investigated the potential influence of human genetic variation on the HIV-1 reservoir size and its decay r ...

LIPPINCOTT WILLIAMS & WILKINS2020

SPHN/PHRT - MedCo in Action: Empowering the Swiss Molecular Tumor Board with Privacy-Preserving and Real-Time Patient Discovery

Jean-Pierre Hubaux, Mickaël Misbach, Jacques Fellay, Joao André Gomes de Sá e Sousa, Juan Ramón Troncoso-Pastoriza

MedCo is the first operational system that makes sensitive medical-data available for research in a simple, privacy-conscious and secure way. It enables a consortium of clinical sites to collectively protect their data and to securely share them with inves ...

IOS PRESS2020

An indel in the promoter region of NFKB1 confers protection against infection but increases risk of allergy

Jacques Fellay, Flavia Aurelia Shoko Hodel

SPRINGERNATURE2020

Exploring the interactions between the human and viral genomes

Jacques Fellay

Over the last decade, genome-wide association studies led to major advances in identifying human genetic variants associated with infectious disease susceptibility. On the pathogen side, comparable methods are now applied to identify disease-modulating pat ...

SPRINGER2020

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Jacques Fellay, Zhiyong Liu, Xavier Duval, Rui Yang, Qian Zhang, Juan Li, Jie Chen, Peng Zhang, Yu Zhang

Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function (LOF ...

American Association for the Advancement of Science2020

Whole-exome Sequencing for the Identification of Rare Variants in Primary Immunodeficiency Genes in Children With Sepsis: A Prospective, Population-based Cohort Study

Samira Asgari, Jacques Fellay, Nimisha Chaturvedi, Christian Axel Wandall Thorball, Alessandro Borghesi

Background. The role of primary immunodeficiencies (PID) in susceptibility to sepsis remains unknown. It is unclear whether children with sepsis benefit from genetic investigations. We hypothesized that sepsis may represent the first manifestation of under ...

OXFORD UNIV PRESS INC2020

Assessing the impact of non-pharmaceutical interventions on SARS-CoV-2 transmission in Switzerland

Andrea Rinaldo, Francisco Javier Perez Saez, Joseph Chadi Benoit Lemaitre, Jacques Fellay

Following the rapid dissemination of COVID-19 cases in Switzerland, large-scale non-pharmaceutical interventions (NPIs) were implemented by the cantons and the federal government between 28 February and 20 March 2020. Estimates of the impact of these inter ...

2020

Designing a Tanzanian Specific SNP Array Add-On to Capture Population-Specific Genetic Variations and to Improve Genotype Imputation

Jacques Fellay, Zhirui Xu

KARGER2020

A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals

Jacques Fellay, Flavia Aurelia Shoko Hodel, Christian Hammer, Petar Scepanovic

Background The gut microbiome is an important determinant of human health. Its composition has been shown to be influenced by multiple environmental factors and likely by host genetic variation. In the framework of the Milieu Interieur Consortium, a total ...

2019

Associations between usual diet and gut microbiota composition: results from the Milieu Interieur cross-sectional study

Jacques Fellay

Background: Diet is widely recognized as one of the main modifiable drivers of gut microbiota variability, and its influence on microbiota composition is an active area of investigation. ...

OXFORD UNIV PRESS2019

Blacklisting variants common in private cohorts but not in public databases optimizes human exome analysis

Jacques Fellay, Alessandro Borghesi

Computational analyses of human patient exomes aim to filter out as many nonpathogenic genetic variants (NPVs) as possible, without removing the true disease-causing mutations. This involves comparing the patient's exome with public databases to remove rep ...

National Academy of Sciences2019

Predicting the Occurrence of Variants in RAG1 and RAG2

Jacques Fellay, Flavia Aurelia Shoko Hodel, Dylan Lawless

While widespread genome sequencing ushers in a new era of preventive medicine, the tools for predictive genomics are still lacking. Time and resource limitations mean that human diseases remain uncharacterized because of an inability to predict clinically ...

2019

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