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Emilia Paunescu

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Publications associées (22)

Page 1 sur 2

Nonsteroidal Anti-inflammatory-Organometallic Anticancer Compounds

Paul Joseph Dyson, Rosario Scopelliti, Emilia Paunescu, Mylène Soudani

Compounds that combine metal-based drugs with covalently linked targeted organic agents have been shown, in some instances, to exhibit superior anticancer properties compared to the individual counterparts. Within this framework, we prepared a series of or ...

Amer Chemical Soc2016

Antiangiogenic and Anticancer Properties of Bifunctional Ruthenium(II)-p-Cymene Complexes: Influence of Pendant Perfluorous Chains

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu

Two bifunctional ruthenium(II)-p-cymene complexes with perfluorinated side chains, attached via pyridine ligands, have been evaluated in a series of in vitro and in vivo assays. Their effects on human endothelial (ECRF24 and HUVEC) cells, noncancerous huma ...

Amer Chemical Soc2015

How Strong Is Hydrogen Bonding in Ionic Liquids? Combined X-ray Crystallographic, Infrared/Raman Spectroscopic, and Density Functional Theory Study

Paul Joseph Dyson, Rosario Scopelliti, Gabor Laurenczy, Zhaofu Fei, Ning Yan, Emilia Paunescu

Hydrogen bonding in ionic liquids based on the 1-(2'-hydroxylethyl)-3-methylimidazolium cation (C(2)OHmim) and various anions (A) of differing H-bond acceptor strength, viz. hexafluorophosphate PF6, tetrafluoroborate BF4, bis-(trifluoro ...

American Chemical Society2013

Arene Osmium Complexes with Ethacrynic Acid-Modified Ligands: Synthesis, Characterization, and Evaluation of Intracellular Glutathione S-Transferase Inhibition and Antiproliferative Activity

Paul Joseph Dyson, Tina Riedel, Emilia Paunescu

Four arene osmium complexes were prepared containing derivatives of ethacrynic acid, a potent inhibitor of glutathione Stransferases, either by direct coordination or via N- or P-donor ligands. The complexes were characterized by spectroscopic and analytic ...

American Chemical Society2016

Phosphorylation of Diaminopyridines: Synthesis of a Compound Containing Both a Diphosphinoamine ( P-N-P) and an Iminobiphosphine ( N=P-P) Fragment

Paul Joseph Dyson, Rosario Scopelliti, Zhaofu Fei, Wee Han Ang, Emilia Paunescu

The phosphorylation of a series of diaminopyridines (2,3-, 3,4-, 2,5- and 2,6-diaminopyridine), with various molecular equivalents of chlorodiphenylphosphine in the presence of TEA has been studied. Notably, phosphorylation of 2,3- and 3,4-diaminopyridine ...

Wiley-V C H Verlag Gmbh2014

A simple catalyst for aqueous phase Suzuki reactions based on palladium nanoparticles immobilized on an ionic polymer

Paul Joseph Dyson, Gabor Laurenczy, Zhaofu Fei, Emilia Paunescu

Palladium nanoparticles immobilized on a cross-linked imidazolium-containing polymer were evaluated as a catalyst for Suzuki carbon-carbon cross-coupling reactions using water as the solvent. The nanocatalysts show good catalytic activities for aryl iodide ...

Science Press2016

Cycloaddition of CO2 to epoxides catalyzed by imidazolium-based polymeric ionic liquids

Paul Joseph Dyson, Gabor Laurenczy, Zhaofu Fei, Ning Yan, Felix Daniel Bobbink, Emilia Paunescu, Huizhen Liu

A series of cross-linked ionic polymers based on styrene-functionalized imidazolium salts with chloride, hexafluorophosphate, or tetrafluoroborate counter anions have been prepared and characterized using a range of analytical and spectroscopic techniques ...

Royal Society of Chemistry2013

Towards a frustrated Lewis pair-ionic liquid system

Paul Joseph Dyson, Rosario Scopelliti, Gabor Laurenczy, Zhaofu Fei, Felix Daniel Bobbink, Emilia Paunescu, Florian Gérald Abela

An ionic liquid encompassing a bulky tertiary amine was synthesized and used as a dual solvent-reactant for the formation of a frustrated Lewis pair with tris(pentafluorophenyl) borane, forming a pseudo-frustrated Lewis pair-ionic liquid system. The ionic ...

Elsevier2018

Influence of Elemental Iodine on Imidazolium-Based Ionic Liquids: Solution and Solid-State Effects

Paul Joseph Dyson, Rosario Scopelliti, Zhaofu Fei, Felix Daniel Bobbink, Emilia Paunescu

Ionic liquids doped with I-2, usually resulting in the formation of polyiodide anions, are extensively used as electrolytes and in iodination reactions. Herein, NMR spectroscopy and single-crystal X-ray diffraction were used to rationalize the structures o ...

2015

In vivo evaluation of small-molecule thermoresponsive anticancer drugs potentiated by hyperthermia

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu

Hyperthermia used as an adjuvant with chemotherapy is highly promising in the treatment of certain cancers. Currently, the small molecule drugs used in combination with hyperthermia were not designed for this application. Herein, we report the evaluation o ...

2015

Synthesis and Antiproliferative Activity of New Ruthenium Complexes with Ethacrynic-Acid-Modified Pyridine and Triphenylphosphine Ligands

Paul Joseph Dyson, Tina Riedel, Emilia Paunescu

Pyridine- and phosphine-based ligands modified with ethacrynic acid (a broad acting glutathione transferase inhibitor) were prepared and coordinated to ruthenium(II)-arene complexes and to a ruthenium(III) NAMI-A type complex. All the compounds (ligands an ...

Amer Chemical Soc2015

Varying the metal to ethacrynic acid ratio in ruthenium(ii)/osmium(ii)-p-cymene conjugates

Paul Joseph Dyson, Catherine Marie Amélie Clavel, Emilia Paunescu, Mylène Soudani

Following the identification of a ruthenium(II)-arene complex with an ethacrynic acid-modified imidazole ligand, which inhibits glutathione transferase (GST) and is cytotoxic to chemo-resistant cancer cells, a series of structurally related ruthenium(II)- ...

Elsevier2017

Thermoresponsive fluorinated small-molecule drugs: a new concept for efficient localized chemotherapy

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu

Hyperthermia is currently being explored as an adjuvant treatment to conventional therapies with chemotherapeutic agents based on thermoresponsive macromolecules. Although the concept of hyperthermia has existed for many years it has yet to become routinel ...

2015

Anticancer Organometallic Osmium(II)-p-cymene Complexes

Paul Joseph Dyson, Rosario Scopelliti, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu

Osmium compounds are attracting increasing attention as potential anticancer drugs. In this context, a series of bifunctional organometallic osmium(II)-p-cymene complexes functionalized with alkyl or perfluoroalkyl groups were prepared and screened for the ...

Wiley-V C H Verlag Gmbh2015

Influence of the Linker Length on the Cytotoxicity of Homobinuclear Ruthenium(II) and Gold(I) Complexes

Paul Joseph Dyson, Rosario Scopelliti, Emilia Paunescu, Lucinda Kate Batchelor, Mylène Soudani

Dinudear metal complexes have emerged as a promising class of anticancer compounds with the ability to cross-link biomolecular targets. Here, we describe two novel series of phosphine-linked dinudear ruthenium(II) p-cyrnene and gold(I) complexes, in which ...

2017

Modulating the Anticancer Activity of Ruthenium(II)-Arene Complexes

Paul Joseph Dyson, Rosario Scopelliti, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu

Following the identification of [Ru(eta(6)-p-cymene)Cl-2(1H,1H,2H,2H-perfluorodecyl-3-(pyridin-3-yl)propanoate)], a ruthenium(II)arene complex with a perfluoroalkyl-modified ligand that displays remarkable in vitro cancer cell selectivity, a series of stru ...

Amer Chemical Soc2015

Anti-angiogenic properties of chlorambucil derivatives with fluorous and hydrocarbon appendages

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu, Andrea Brett Gasser

Chlorambucil (CLB) derivatives with long fluorous (referred to as 1 and 2) or hydrocarbon (3) chains have been evaluated in a series of in vitro and in vivo assays. In cell viability inhibition assays, both derivatives 2 and 3 show selective cytotoxicity t ...

Royal Society of Chemistry2016

Perfluorinated ruthenium(II) complexes with improved anti-angiogenic or anti-cancer activity

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu

Springer2014

Discovery of a Highly Tumor-Selective Organometallic Ruthenium(II)-Arene Complex

Paul Joseph Dyson, Rosario Scopelliti, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu

A ruthenium(II)-arene complex with a perfluoroalkyl-ligand was found to display remarkable selectivity toward cancer cells. IC50 values on several cancer cell lines are in the range of 25-45 mu M, and no cytotoxic effect was observed on nontumorigenic (HEK ...

Amer Chemical Soc2014

Organometallic Glutathione S-Transferase Inhibitors

Paul Joseph Dyson, Rosario Scopelliti, Emilia Paunescu, Mylène Soudani

A new family of organometallic p-cymene ruthenium(II) and osmium(II) complexes conjugated to ethacrynic acid, a glutathione transferase (GST) inhibitor, is reported. The ethacrynic acid moiety (either one or two) is tethered to the arene ruthenium(II) and ...

2017