Publications de Laurent Mouchiroud

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The ability to respond to various intracellular and/or extracellular stresses allows the organism to adapt to changing environmental conditions and drives evolution. It is now well accepted that a progressive decline of the efficiency of stress response pa ...

In this work, we present a novel microfluidic approach to culture the nematode C. elegans from the onset of embryogenesis to the adult stage at single animal resolution. Our device allows high-throughput experimentation, high-resolution imaging, thereby pr ...

Phosphorylation of the N‐terminal domain of the huntingtin (HTT ) protein has emerged as an important regulator of its localization, structure, aggregation, clearance and toxicity. However, validation of the effect of bona fide phosphorylation in vivo and ...

The present invention relates to methods of increasing lifespan, delaying aging, and/or preventing or treating an age-related disease or a mitochondrialdisease in a subject, comprising inducing a nuclear-mitochondrial OXPHOS protein dyssynchrony, including ...

We present a multiplexed and automated microfluidic platform for phenotyping of C. elegans during their full lifespan and at high-throughput. We used the fluorescent hsp-6::gfp strain of worms and performed experiments to observe the effect of four differe ...

The present invention is directed to a method of treating an amyloid-3 peptide disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound that enhances mitochondrial proteostasi ...

Fast, label-free, high-resolution, three-dimensional imaging platforms are crucial for high-throughput in vivo time-lapse studies of the anatomy of Caenorhabditis elegans, one of the most commonly used model organisms in biomedical research. Despite the ne ...

The present invention provides methods of treating various disorders associated with mitochondrial dysfunction, including but not limited to metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, and diseases of aging. ...

Laurent Mouchiroud

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The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease

Automated High-Content Phenotyping Of The Nematode C. Elegans At Single Animal Resolution With A Microfluidic Platform

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

Mitochondrial ribosomal proteins as aging regulators

A microfluidic platform for automated phenotyping during full lifespan of Caenorhabditis elegans at high-throughput

Methods of treating amyloid-beta peptide diseases

An automated microfluidic platform for reversible immobilization and imaging of C. elegans

Label-free three-dimensional imaging of Caenorhabditis elegans with visible optical coherence microscopy

Methods of treating mitochondrial dysfunction