Recherche

Afficher tous les résultats pour

Accueil

Personne

Paulo Henrique Jacob Silva

Cette personne n’est plus à l’EPFL

À propos
Confidentialité
Mentions légales

Graph Chatbot

Publications associées (35)

Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM

Hilal Lashuel, Anass Chiki, Nadine Aït Bouziad, Francesco Stellacci, Paulo Henrique Jacob Silva, Marie Mueller, Zekiye Pelin Güven, Sophie Vieweg, Urszula Beata Cendrowska

Increasing evidence suggests that amyloid polymorphism gives rise to different strains of amyloids with distinct toxicities and pathology-spreading properties. Validating this hypothesis is challenging due to a lack of tools and methods that allow for the ...

National Academy of Sciences2020

Non-Toxic Virucidal Macromolecules Show High Efficacy Against Influenza Virus Ex Vivo and In Vivo

Francesco Stellacci, Paulo Henrique Jacob Silva, Özgün Kocabiyik, Valeria Cagno, Yong Zhu, Chiara Medaglia

Influenza is one of the most widespread viral infections worldwide and represents a major public health problem. The risk that one of the next pandemics is caused by an influenza strain is high. It is important to develop broad-spectrum influenza antiviral ...

2020

Synthesis and Characterization of Amphiphilic Gold Nanoparticles

Francesco Stellacci, Paulo Henrique Jacob Silva, Zekiye Pelin Güven, Zhi Luo, Samuel Thomas Jones, Urszula Beata Cendrowska, Matteo Gasbarri

Gold nanoparticles covered with a mixture of 1-octanethiol (OT) and 11-mercapto-1-undecane sulfonic acid (MUS) have been extensively studied because of their interactions with cell membranes, lipid bilayers, and viruses. The hydrophilic ligands make these ...

JOURNAL OF VISUALIZED EXPERIMENTS2019

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism

Francesco Stellacci, Paulo Henrique Jacob Silva, Marie Mueller, Ahmet Bekdemir, Samuel Thomas Jones, Emma-Rose Janecek, Valeria Cagno

Viral infections kill millions yearly. Available antiviral drugs are virus-specific and active against a limited panel of human pathogens. There are broad-spectrum substances that prevent the first step of virus–cell interaction by mimicking heparan sulfat ...

2018

Evolution of Nanoparticle Protein Corona across the Blood-Brain Barrier

Francesco Stellacci, Paulo Henrique Jacob Silva

2018

Structure-Property Relationships of Amphiphilic Nanoparticles That Penetrate or Fuse Lipid Membranes

Davide Demurtas, Francesco Stellacci, Randy Patrick Carney, Paulo Henrique Jacob Silva, Zekiye Pelin Güven, Ye Yang, Ahmet Bekdemir

2018

Distribution of superparamagnetic Au/Fe nanoparticles in an isolated guinea pig brain with an intact blood brain barrier

Francesco Stellacci, Paulo Henrique Jacob Silva

Diagnosis and treatment of brain disorders, such as epilepsy, neurodegenerative diseases and tumors, would benefit from innovative approaches to deliver therapeutic or diagnostic compounds into the brain parenchyma, with either a homogeneous or a targeted ...

ROYAL SOC CHEMISTRY2018

Superparamagnetic Nanoparticles as High Efficiency Magnetic Resonance Imaging T-2 Contrast Agent

Kurt Schenk, Henrik Moodysson Rønnow, Arash Alahgholipour Omrani, Francesco Stellacci, Randy Patrick Carney, Paulo Henrique Jacob Silva, Tamara Michael Carney, Ping Huang, Lin Yang

Nanoparticle-based magnetic resonance imaging T-2 negative agents are of great interest, and much effort is devoted to increasing cell loading capability while maintaining low cytotoxicity. Herein, two classes of mixed-ligand protected magnetic-responsive, ...

American Chemical Society2017

Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months

Francesco Stellacci, Randy Patrick Carney, Paulo Henrique Jacob Silva, Valeria Cagno

Up to 80% of the cost of vaccination programmes is due to the cold chain problem (that is, keeping vaccines cold). Inexpensive, biocompatible additives to slow down the degradation of virus particles would address the problem. Here we propose and character ...

Nature Publishing Group2016

Discriminative adsorption of amphiphilic monolayer protected gold nanoparticles on amyloid fibers

Paulo Henrique Jacob Silva

This thesis presents a systematic study of how different types monolayer-protected AuNPs interact with amyloid fibers. We report a class of amphiphilic gold nanoparticles capable of adsorbing onto specific surface features on these types of protein fibers. ...

EPFL2016

Influence of the glycocalyx and plasma membrane composition on amphiphilic gold nanoparticle association with erythrocytes

Francesco Stellacci, Randy Patrick Carney, Paulo Henrique Jacob Silva, Ye Yang, Ahmet Bekdemir

Erythrocytes are attractive as potential cell-based drug carriers because of their abundance and long life-span in vivo. Existing methods for loading drug cargos into erythrocytes include hypotonic treatments, electroporation, and covalent attachment onto ...

Royal Society of Chemistry2015

Lipid tail protrusions mediate the insertion of nanoparticles into model cell membranes

Francesco Stellacci, Kislon Voitchovsky, Maria Ricci, Javier Reguera Gomez, Paulo Henrique Jacob Silva

Recent work has demonstrated that charged gold nanoparticles (AuNPs) protected by an amphiphilic organic monolayer can spontaneously insert into the core of lipid bilayers to minimize the exposure of hydrophobic surface area to water. However, the kinetic ...

Nature Publishing Group2014

High-Resolution Scanning Tunneling Microscopy Characterization of Mixed Monolayer Protected Gold Nanoparticles

Christoph Renner, Francesco Stellacci, Quy Ong Khac, Javier Reguera Gomez, Mauro Moglianetti, Paulo Henrique Jacob Silva, Kellen Michael Harkness

Gold nanoparticles protected by a binary mixture of thiolate molecules have a ligand shell that can spontaneously separate into nanoscale domains. Complex morphologies arise in such ligand shells, including striped, patchy, and Janus domains. Characterizat ...

American Chemical Society2013

Electrical Method to Quantify Nanoparticle Interaction with Lipid Bilayers

Francesco Stellacci, Kislon Voitchovsky, Randy Patrick Carney, Paulo Henrique Jacob Silva, Tamara Michael Carney

Understanding as well as rapidly screening the interaction of nanoparticles with cell membranes is of central importance for biological applications such as drug and gene delivery. Recently, we have shown that "striped" mixed-monolayer-coated gold nanopart ...

American Chemical Society2013

High-resolution scanning tunneling microscopy characterization of mixed monolayer coated gold nanoparticles

Francesco Stellacci, Quy Ong Khac, Javier Reguera Gomez, Mauro Moglianetti, Paulo Henrique Jacob Silva, Kellen Michael Harkness

Amer Chemical Soc2013

Page 2 sur 2