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Paulo Henrique Jacob Silva

Cette personne a quitté l’EPFL

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Publications associées (33)

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Inhibition of influenza virus infection in mice by pulmonary administration of a spray dried antiviral drug

Francesco Stellacci, Aurélien Bornet, Paulo Henrique Jacob Silva, Sujeet Pawar

Increasing resistance to antiviral drugs approved for the treatment of influenza urges the development of novel compounds. Ideally, this should be complemented by a careful consideration of the administration route. 6′siallyllactosamine-functionalized β-cy ...

2024

Development of Broad-Spectrum β-Cyclodextrins-Based Nanomaterials Against Influenza Viruses

Francesco Stellacci, Paulo Henrique Jacob Silva, Yong Zhu

In recent decades, epidemics and pandemics have multiplied throughout the world, with viruses generally being the primary responsible agents. Among these, influenza viruses play a key role, as they potentially cause severe respiratory distress, representin ...

2024

Experimental Method to Distinguish between a Solution and a Suspension

Francesco Stellacci, Quy Ong Khac, Paulo Henrique Jacob Silva, Xufeng Xu, Ting Mao

Dispersion of objects in a fluid phase can be classified as solutions (Gibbs free energy of mixing, Delta G(mix) < 0) or suspensions (Delta G(mix) > 0) depending on their thermodynamic stability. Small objects tend to form solutions, larger ones suspension ...

WILEY2022

Site-selective overgrowth of Ag nanocrystals by Polyvinylpyrrolidone-mediated atom deposition by Ostwald ripening

Francesco Stellacci, Paulo Henrique Jacob Silva

The growth modulation of metal nanocrystals (NCs) by Ostwald ripening (OR) involves control of the relocation of matter by diffusional mass transfer from the dissolution of small nanocrystals (SNCs) towards large nanocrystals whose surface energy is lower. ...

ELSEVIER2022

The Clustering of mApoE Anti-Amyloidogenic Peptide on Nanoparticle Surface Does Not Alter Its Performance in Controlling Beta-Amyloid Aggregation

Francesco Stellacci, Paulo Henrique Jacob Silva

The deposition of amyloid-beta (A beta) plaques in the brain is a significant pathological signature of Alzheimer's disease, correlating with synaptic dysfunction and neurodegeneration. Several compounds, peptides, or drugs have been designed to redirect o ...

2020

Cholesterol-Containing Liposomes Decorated With Au Nanoparticles as Minimal Tunable Fusion Machinery

Francesco Stellacci, Paulo Henrique Jacob Silva

Membrane fusion is essential for the basal functionality of eukaryotic cells. In physiological conditions, fusion events are regulated by a wide range of specialized proteins, operating with finely tuned local lipid composition and ionic environment. Fusog ...

WILEY-V C H VERLAG GMBH2023

Structure-Activity Relationship Studies of Glycosaminoglycan Mimetic Macrocycles Against Herpes

Cynthia Paloma Aigroz, Hien Tran Thi, Deepika Sardana, Anita Zucchi, Francesco Stellacci, Paulo Henrique Jacob Silva, Melis Özkan, Sujeet Pawar

The herpes simplex virus (HSV) is associated with serious conditions, such as encephalitis and blindness, and its infection is closely linked to significant vascular complications and coagulation issues, particularly in individuals with compromised immune ...

AMER CHEMICAL SOC2025

Broad-spectrum nanoparticles against bacteriophage infections

Francesco Stellacci, Paulo Henrique Jacob Silva, Matteo Gasbarri, Urszula Beata Cendrowska, Francesca Olgiati, Zekiye Pelin Güven, Lukasz Richter

Viral infections caused by bacteriophages, i.e., viruses that kill bacteria are one of the most dangerous and common threats for bacteria-based bioreactors. More than 70% of biotechnology companies have admitted to encountering this problem. Despite phage ...

ROYAL SOC CHEMISTRY2021

High-Resolution Scanning Tunneling Microscopy Characterization of Mixed Monolayer Protected Gold Nanoparticles

Francesco Stellacci, Paulo Henrique Jacob Silva, Quy Ong Khac, Javier Reguera Gomez, Kellen Michael Harkness, Mauro Moglianetti

Gold nanoparticles protected by a binary mixture of thiolate molecules have a ligand shell that can spontaneously separate into nanoscale domains. Complex morphologies arise in such ligand shells, including striped, patchy, and Janus domains. Characterizat ...

American Chemical Society2013

Reversible Microscale Assembly of Nanoparticles Driven by the Phase Transition of a Thermotropic Liquid Crystal

Francesco Stellacci, Holger Frauenrath, Paulo Henrique Jacob Silva, Stephen Schrettl, Kellen Michael Harkness

The arrangement of nanoscale building blocks into patternswithmicroscale periodicity is challenging to achieve via self-assemblyprocesses. Here, we report on the phase-transition-driven collectiveassembly of gold nanoparticles in a thermotropic liquid crys ...

AMER CHEMICAL SOC2023

Interferon Lambda Delays the Emergence of Influenza Virus Resistance to Oseltamivir

Francesco Stellacci, Paulo Henrique Jacob Silva

Influenza viruses are a leading cause of morbidity and mortality worldwide. These air-borne pathogens are able to cross the species barrier, leading to regular seasonal epidemics and sporadic pandemics. Influenza viruses also possess a high genetic variabi ...

2021

Synthesis and Characterization of Amphiphilic Gold Nanoparticles

Francesco Stellacci, Paulo Henrique Jacob Silva, Matteo Gasbarri, Zhi Luo, Zekiye Pelin Güven, Urszula Beata Cendrowska, Samuel Thomas Jones

Gold nanoparticles covered with a mixture of 1-octanethiol (OT) and 11-mercapto-1-undecane sulfonic acid (MUS) have been extensively studied because of their interactions with cell membranes, lipid bilayers, and viruses. The hydrophilic ligands make these ...

JOURNAL OF VISUALIZED EXPERIMENTS2019

Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM

Francesco Stellacci, Hilal Lashuel, Paulo Henrique Jacob Silva, Anass Chiki, Nadine Aït Bouziad, Urszula Beata Cendrowska, Zekiye Pelin Güven, Senthil Kumar Thangaraj, Sophie Vieweg

Increasing evidence suggests that amyloid polymorphism gives rise to different strains of amyloids with distinct toxicities and pathology-spreading properties. Validating this hypothesis is challenging due to a lack of tools and methods that allow for the ...

National Academy of Sciences2020

Influence of the glycocalyx and plasma membrane composition on amphiphilic gold nanoparticle association with erythrocytes

Francesco Stellacci, Paulo Henrique Jacob Silva, Randy Patrick Carney, Ahmet Bekdemir

Erythrocytes are attractive as potential cell-based drug carriers because of their abundance and long life-span in vivo. Existing methods for loading drug cargos into erythrocytes include hypotonic treatments, electroporation, and covalent attachment onto ...

Royal Society of Chemistry2015

Site-selective surface enhanced Raman scattering study of ligand exchange reactions on aggregated Ag nanocubes

Francesco Stellacci, Paulo Henrique Jacob Silva, Zekiye Pelin Güven, Evangelia-Nefeli Athanasopoulou

Surface modification of ligand protected nanoparticles (NPs) can be driven by ligand exchange reactions (LER). Little is known about the mechanism of this reaction, especially when the particles are not spherical. Here, we use the intrinsic hot spots gener ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2022

Discriminative adsorption of amphiphilic monolayer protected gold nanoparticles on amyloid fibers

Paulo Henrique Jacob Silva

This thesis presents a systematic study of how different types monolayer-protected AuNPs interact with amyloid fibers. We report a class of amphiphilic gold nanoparticles capable of adsorbing onto specific surface features on these types of protein fibers. ...

EPFL2016

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism

Francesco Stellacci, Paulo Henrique Jacob Silva, Ahmet Bekdemir, Valeria Cagno, Emma-Rose Janecek, Samuel Thomas Jones

Viral infections kill millions yearly. Available antiviral drugs are virus-specific and active against a limited panel of human pathogens. There are broad-spectrum substances that prevent the first step of virus–cell interaction by mimicking heparan sulfat ...

2018

Development of an inhalable antiviral powder formulation against respiratory syncytial virus

Francesco Stellacci, Paulo Henrique Jacob Silva, Daniel Ortiz Trujillo, Matteo Gasbarri

Respiratory viruses including the respiratory syncytial virus (RSV) aggravate the global burden of virus-inflicted morbidity and mortality. Entry inhibitors are a promising class of antiviral drugs for combating these viruses, as they can prevent infection ...

ELSEVIER2023

Non-Toxic Virucidal Macromolecules Show High Efficacy Against Influenza Virus Ex Vivo and In Vivo

Francesco Stellacci, Paulo Henrique Jacob Silva, Valeria Cagno, Özgün Kocabiyik, Yong Zhu

Influenza is one of the most widespread viral infections worldwide and represents a major public health problem. The risk that one of the next pandemics is caused by an influenza strain is high. It is important to develop broad-spectrum influenza antiviral ...

2020

Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months

Francesco Stellacci, Paulo Henrique Jacob Silva, Randy Patrick Carney, Valeria Cagno

Up to 80% of the cost of vaccination programmes is due to the cold chain problem (that is, keeping vaccines cold). Inexpensive, biocompatible additives to slow down the degradation of virus particles would address the problem. Here we propose and character ...

Nature Publishing Group2016