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Francesco Stellacci

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Publications associées (208)

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Nanoparticle-Induced Disorder at Complex Liquid-Liquid Interfaces: Effects of Curvature and Compositional Synergy on Functional Surfaces

Francesco Stellacci, Youwei Ma

The self-assembly of surfactant monolayers at interfaces plays a sweeping role in tasks ranging from household cleaning to the regulation of the respiratory system. The synergy between different nanoscale species at an interface can yield assemblies with e ...

AMER CHEMICAL SOC2021

Bimodal atomic force microscopy for the characterization of thiolated self-assembled monolayers

Francesco Stellacci, Quy Ong Khac, Nikolaos Nianias, Evangelia-Nefeli Athanasopoulou

Surface coatings are becoming an integral part of materials. In recent years, molecular coatings have found larger acceptance and uses. Among them, self-assembled monolayers (SAMs) are attractive due to their inherent versatility, manufacturability, and sc ...

ROYAL SOC CHEMISTRY2018

Comparative characterisation of non-monodisperse gold nanoparticle populations by X-ray scattering and electron microscopy

Francesco Stellacci, Stefan Guldin, Zhi Luo, Suiyang Liao

Accurate nanoparticle size determination is essential across various research domains, with many functionalities in nanoscience and biomedical research being size-dependent. Although electron microscopy is capable of resolving a single particle down to the ...

2020

3D to 2D reorganization of silver-thiol nanostructures, triggered by solvent vapor annealing

Francesco Stellacci, Sergio Allegri

Metal-organic composites are of great interest for a wide range of applications. The control of their structure remains a challenge, one of the problems being a complex interplay of covalent and supramolecular interactions. This paper describes the self-as ...

2018

The Clustering of mApoE Anti-Amyloidogenic Peptide on Nanoparticle Surface Does Not Alter Its Performance in Controlling Beta-Amyloid Aggregation

Francesco Stellacci, Paulo Henrique Jacob Silva

The deposition of amyloid-beta (A beta) plaques in the brain is a significant pathological signature of Alzheimer's disease, correlating with synaptic dysfunction and neurodegeneration. Several compounds, peptides, or drugs have been designed to redirect o ...

2020

Simultaneous Electrophysiology and Imaging Reveal Changes in Lipid Membrane Thickness and Tension upon Uptake of Amphiphilic Gold Nanoparticles

Francesco Stellacci, Paulo Henrique Jacob Silva, Xufeng Xu

Amphiphilic gold core nanoparticles (AmNPs) striped with hydrophilic 11-mercapto-1-undecanesulfonate (MUS) and hydrophobic 1-octanethiol (OT) ligands are promising candidates for drug carriers that passively and nondisruptively enter cells. Yet, how they i ...

Amer Chemical Soc2023

Modulating Weak Protein-Protein Cross-Interactions by the Addition of Free Amino Acids at Millimolar Concentrations

Pamina Winkler, Francesco Stellacci, Cécilia Laetitia Carla Siri

In this paper, we quantify weak protein-protein interactions in solution using cross-interaction chromatography (CIC) and surface plasmon resonance (SPR) and demonstrate that they can be modulated by the addition of millimolar concentrations of free amino ...

2024

Patchy Amphiphilic Dendrimers Bind Adenovirus and Control Its Host Interactions and in Vivo Distribution

Francesco Stellacci, Weina Liu

The surface of proteins is heterogeneous with sophisticated but precise hydrophobic and hydrophilic patches, which is essential for their diverse biological functions. To emulate such distinct surface patterns on macromolecules, we used rigid spherical syn ...

2019

Co-precipitation of oppositely charged nanoparticles: the case of mixed ligand nanoparticles

Francesco Stellacci, Javier Reguera Gomez, Mauro Moglianetti

Colloid stability is of high importance in a multitude of fields ranging from food science to biotechnology. There is strong interest in studying the stability of small particles (of a size of a few nanometres) with complex surface structures, that make th ...

Institute of Physics2015

Influenza A(H1N1)pdm09 virus resistance to baloxavir, oseltamivir and sialic acid mimetics in single and dual therapies: Insights from human airway epithelia and murine models

Francesco Stellacci

Influenza viruses pose a significant threat due to annual epidemics and pandemic potential. Resistance to current antivirals underscores the need for new drugs and strategies to prevent its emergence. We previously developed two novel HA-targeting compound ...

Elsevier BV2025

Cholesterol-Containing Liposomes Decorated With Au Nanoparticles as Minimal Tunable Fusion Machinery

Francesco Stellacci, Paulo Henrique Jacob Silva

Membrane fusion is essential for the basal functionality of eukaryotic cells. In physiological conditions, fusion events are regulated by a wide range of specialized proteins, operating with finely tuned local lipid composition and ionic environment. Fusog ...

WILEY-V C H VERLAG GMBH2023

In-situ Investigations on Gold Nanoparticles Stabilization Mechanisms in Biological Environments Containing HSA

Francesco Stellacci, Quy Ong Khac, Antonia Neels, Marianne Liebi

Nanoparticles (NPs) developments advance innovative biomedical applications. However, complex interactions and the low colloidal stability of NPs in biological media restrict their widespread utilization. The influence of NPs properties on the colloidal st ...

WILEY-V C H VERLAG GMBH2021

Mass spectrometry and Monte Carlo method mapping of nanoparticle ligand shell morphology

Francesco Stellacci, Zhi Luo, Yanfei Zhao, Jing Hou

Janus, patchy, stripe-like, or random arrangements of molecules within the ligand shell of nanoparticles affect many properties. Among all existing ligand shell morphology characterization methods, the one based on mass spectroscopy is arguably the simples ...

Nature Publishing Group2018

Structure-Activity Relationship Studies of Glycosaminoglycan Mimetic Macrocycles Against Herpes

Cynthia Paloma Aigroz, Hien Tran Thi, Deepika Sardana, Anita Zucchi, Francesco Stellacci, Paulo Henrique Jacob Silva, Melis Özkan, Sujeet Pawar

The herpes simplex virus (HSV) is associated with serious conditions, such as encephalitis and blindness, and its infection is closely linked to significant vascular complications and coagulation issues, particularly in individuals with compromised immune ...

AMER CHEMICAL SOC2025

Enhancing Radiotherapy by Lipid Nanocapsule-Mediated Delivery of Amphiphilic Gold Nanoparticles to Intracellular Membranes

Francesco Stellacci, Randy Patrick Carney

Amphiphilic gold nanoparticles (amph-NPs), composed of gold cores surrounded by an amphiphilic mixed organic ligand shell, are capable of embedding within and traversing lipid membranes. Here we describe a strategy using crosslink-stabilized lipid nanocaps ...

American Chemical Society2014

Broad-Spectrum Antiviral Agents Based on Multivalent Inhibitors of Viral Infectivity

Francesco Stellacci

The ongoing pandemic of the coronavirus disease (Covid-19), caused by the spread of the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), highlights the need for broad-spectrum antiviral drugs. In this Essay, it is argued that such agents alrea ...

WILEY2021

High-Resolution Scanning Tunneling Microscopy Characterization of Mixed Monolayer Protected Gold Nanoparticles

Francesco Stellacci, Paulo Henrique Jacob Silva, Quy Ong Khac, Javier Reguera Gomez, Kellen Michael Harkness, Mauro Moglianetti

Gold nanoparticles protected by a binary mixture of thiolate molecules have a ligand shell that can spontaneously separate into nanoscale domains. Complex morphologies arise in such ligand shells, including striped, patchy, and Janus domains. Characterizat ...

American Chemical Society2013

A Synthetic Multivalent Lipopeptide Derived from Pam3CSK4 with Irreversible Influenza Inhibition and Immuno-Stimulating Effects

Francesco Stellacci, Bruno Emanuel Ferreira De Sousa Correia, Li Tang, Quy Ong Khac, Pablo Gainza Cirauqui, Lixia Wei, Armand Kurum, Yong Zhu, Francesca Olgiati

The activation of the host adaptive immune system is crucial for eliminating viruses. However, influenza infection often suppresses the innate immune response that precedes adaptive immunity, and the adaptive immune responses are typically delayed. Dendrit ...

Wiley-V C H Verlag Gmbh2024

Broad-Spectrum Supramolecularly Reloadable Antimicrobial Coatings

Alexander Lukas Müller, Inês Cordeiro Filipe, Francesco Stellacci, Matteo Gasbarri, Heyun Wang, Francesca Olgiati, Melis Özkan, Lukasz Richter, Nicolo' Razza, Louisa Rinaldi, Fiora Artusio

Antimicrobial surfaces limit the spread of infectious diseases. To date, there is no antimicrobial coating that has widespread use because of short-lived and limited spectrum efficacy, poor resistance to organic material, and/or cost. Here, we present a pa ...

Amer Chemical Soc2024

Photodynamic treatment of multidrug-resistant bacterial infection using indium phosphide quantum dots

Francesco Stellacci

Infections caused by multidrug-resistant (MDR) bacteria pose an impending threat to humanity, as the evolution of MDR bacteria outpaces the development of effective antibiotics. In this work, we use indium phosphide (InP) quantum dots (QDs) to treat infect ...

ROYAL SOC CHEMISTRY2022