Publications de Francesco Stellacci

Publications associées (208)

Determination of nanoparticle size distribution together with density or molecular weight by 2D analytical ultracentrifugation

Francesco Stellacci, Randy Patrick Carney

Nanoparticles are finding many research and industrial applications, yet their characterization remains a challenge. Their cores are often polydisperse and coated by a stabilizing shell that varies in size and composition. No single technique can character ...

Nature Research2011

Inhibition of influenza virus infection in mice by pulmonary administration of a spray dried antiviral drug

Francesco Stellacci, Aurélien Bornet, Paulo Henrique Jacob Silva, Sujeet Pawar

Increasing resistance to antiviral drugs approved for the treatment of influenza urges the development of novel compounds. Ideally, this should be complemented by a careful consideration of the administration route. 6′siallyllactosamine-functionalized β-cy ...

2024

New approach for time-resolved and dynamic investigations on nanoparticles agglomeration

Francesco Stellacci, Antonia Neels, Alex Dommann, Urszula Beata Cendrowska

Nanoparticle (NP) colloidal stability plays a crucial role in biomedical application not only for human and environmental safety but also for NP efficiency and functionality. NP agglomeration is considered as a possible process in monodispersed NP colloida ...

TSINGHUA UNIV PRESS2020

Nature-Inspired Circular-Economy Recycling for Proteins: Proof of Concept

Francesco Stellacci, Laure Menin, Luc Patiny, Daniel Ortiz Trujillo, Anna Murello, Laura Roset Julia, Shiyu Cheng, Vincenzo Scamarcio, Simone Giaveri

The billion tons of synthetic-polymer-based materials (i.e. plastics) produced yearly are a great challenge for humanity. Nature produces even more natural polymers, yet they are sustainable. Proteins are sequence-defined natural polymers that are constant ...

Wiley2021

Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic

Francesco Stellacci

The COVID-19 outbreak has fueled a global demand for effective diagnosis and treatment as well as mitigation of the spread of infection, all through large-scale approaches such as specific alternative antiviral methods and classical disinfection protocols. ...

AMER CHEMICAL SOC2020

Direct Visualization of Single Ions in the Stern Layer of Calcite

Jean-François Molinari, Francesco Stellacci, Kislon Voitchovsky, Peter Spijker, Maria Ricci

Calcite is among the most abundant minerals on earth and plays a central role in many environmental and geochemical processes. Here we used amplitude modulation atomic force microscopy (AFM) operated in a particular regime to visualize single ions close to ...

American Chemical Society2013

Ion-bridges and lipids drive aggregation of same-charge nanoparticles on lipid membranes

Francesco Stellacci, Zekiye Pelin Güven

The control of the aggregation of biomedical nanoparticles (NP) in physiological conditions is crucial as clustering may change completely the way they interact with the biological environment. Here we show that Au nanoparticles, functionalized by an anion ...

ROYAL SOC CHEMISTRY2022

Development of Broad-Spectrum β-Cyclodextrins-Based Nanomaterials Against Influenza Viruses

Francesco Stellacci, Paulo Henrique Jacob Silva, Yong Zhu

In recent decades, epidemics and pandemics have multiplied throughout the world, with viruses generally being the primary responsible agents. Among these, influenza viruses play a key role, as they potentially cause severe respiratory distress, representin ...

2024

Structure-Property Relationships of Elastomeric Vinylogous Urethane Thermosets and Their Application as Closed-Loop Recyclable Strain Sensors

Francesco Stellacci, Youwei Ma

Developing closed-loop recyclable thermosets and understanding their structure-property relationships are essential steps in advancing a circular materials economy. Here, we present a vinylogous urethane (VU) thermoset with closed-loop recyclability, synth ...

American Chemical Society2025

Determination and evaluation of the nonadditivity in wetting of molecularly heterogeneous surfaces

Francesco Stellacci, Michele Ceriotti, Sylvie Roke, Halil Ibrahim Okur, Quy Ong Khac, David Mark Wilkins, Zhi Luo, Anna Murello, Filip Kovacik

The interface between water and folded proteins is very complex. Proteins have "patchy" solvent-accessible areas composed of domains of varying hydrophobicity. The textbook understanding is that these domains contribute additively to interfacial properties ...

National Academy of Sciences2019

Experimental Method to Distinguish between a Solution and a Suspension

Francesco Stellacci, Quy Ong Khac, Paulo Henrique Jacob Silva, Xufeng Xu, Ting Mao

Dispersion of objects in a fluid phase can be classified as solutions (Gibbs free energy of mixing, Delta G(mix) < 0) or suspensions (Delta G(mix) > 0) depending on their thermodynamic stability. Small objects tend to form solutions, larger ones suspension ...

WILEY2022

An antiviral trap made of protein nanofibrils and iron oxyhydroxide nanoparticles

Francesco Stellacci, Matteo Gasbarri

Minimizing the spread of viruses in the environment is the first defence line when fighting outbreaks and pandemics, but the current COVID-19 pandemic demonstrates how difficult this is on a global scale, particularly in a sustainable and environmentally f ...

Nature Research2021

Antiviral Mechanism of Virucidal Sialic Acid Modified Cyclodextrin

Francesco Stellacci, Paulo Henrique Jacob Silva, Yong Zhu

We have reported that CD-6'SLN [6-sialyllactosamine (6'SLN)-modified beta-cyclodextrin (CD)] can be a potential anti-influenza drug because it irreversibly deactivates virions. Indeed, in vivo, CD-6'SLN improved mice survival in an H1N1 infection model eve ...

MDPI2023

Quantifying the Solution Structure of Metal Nanoclusters Using Small-Angle Neutron Scattering

Huayan Yang, Francesco Stellacci, Stefan Guldin, Zhi Luo

Metal nanoclusters are a unique class of synthetic material, as their crystal structures can be resolved using X-ray diffraction, and their chemical formula can be precisely determinated from mass spectroscopy. However, a complete structure characterizatio ...

Wiley-VCH Verlag GmbH2022

Nucleation and Island Growth of Alkanethiolate Ligand Domains on Gold Nanoparticles

Francesco Stellacci

The metal oxide cluster alpha-AIW(11)O(39)(9-) (1), readily imaged by cryogenic transmission electron microscopy (cryo-TEM), is used as a diagnostic protecting anion to investigate the self-assembly of alkanethiolate monolayers on electrostatically stabili ...

American Chemical Society2012

Amino acids modulate liquid-liquid phase separation in vitro and in vivo by regulating protein-protein interactions

Francesco Stellacci, Xufeng Xu, Laura Roset Julia

Copyright © 2024 the Author(s). Published by PNAS.Liquid-liquid phase separation (LLPS) is an intracellular process widely used by cells for many key biological functions. It occurs in complex and crowded environments, where amino acids (AAs) are vital com ...

National Academy of Sciences2024

Amphiphilic nanoparticles generate curvature in lipid membranes and shape liposome-liposome interfaces

Francesco Stellacci, Francesca Olgiati

We show by molecular dynamics that amphiphilic Au nanoparticles (NP) with a diameter of 4 nm generate curvature in phosphatidylcholine lipid membranes. NPs generate negative curvature when they adsorb on the membrane surface but, as they get spontaneously ...

ROYAL SOC CHEMISTRY2021

An anti-influenza combined therapy assessed by single cell RNA-sequencing

Francesco Stellacci

Influenza makes millions of people ill every year, placing a large burden on the healthcare system and the economy. To develop a treatment against influenza, we combined virucidal sialylated cyclodextrins with interferon lambda and demonstrated, in human a ...

NATURE PORTFOLIO2022

Modified cyclodextrins as broad-spectrum antivirals

Matej Janecek, Francesco Stellacci, Natalia Gasilova, Daniel Ortiz Trujillo, Matteo Gasbarri, Valeria Cagno, Samuel Thomas Jones

Viral infections kill millions of people and new antivirals are needed. Nontoxic drugs that irreversibly inhibit viruses (virucidal) are postulated to be ideal. Unfortunately, all virucidal molecules described to date are cytotoxic. We recently developed n ...

AMER ASSOC ADVANCEMENT SCIENCE2020

Reproducibility warning: The curious case of polyethylene glycol 6000 and spheroid cell culture

Francesco Stellacci, Quy Ong Khac, Zhi Luo, Ahmet Bekdemir

Reproducibility of results is essential for a well-designed and conducted experiment. Several reasons may originate failure in reproducing data, such as selective reporting, low statistical power, or poor analysis. In this study, we used PEG6000 samples fr ...

2020