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Johan Auwerx

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Publications associées (283)

An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function

Stephan Morgenthaler, Kristina Schoonjans, Johan Auwerx, Maroun Bou Sleiman, Hongbo Zhang, Daria Rukina, Karim Laurent Gariani, Xu Wang, Tao Lin, Peiling Luan, Hao Li, Vincenzo Sorrentino, Qingyao Huang, Naveed Ziari

2018

PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis

Johan Auwerx, Zhou Zhou, Dongryeol Ryu, Karim Laurent Gariani, Wei Wang

Background & Aims: Mitochondria) dysfunction, oxidative stress, inflammation, and metabolic reprograming are crucial contributors to hepatic injury and subsequent liver fibrosis. Poly(ADP-ribose) polymerases (PARP) and their interactions with sirtuins play ...

Elsevier Science Bv2017

Agents and methods using thereof for the prevention and treatment of stem cells senescence

Johan Auwerx, Dongryeol Ryu, Hongbo Zhang, Keir Joe Menzies

The present invention relates to agents that prevent or reverse process of stem cell senescence. Further, the invention relates to methods and compositions useful in the prevention and/or treatment of stem senescence. ...

2017

Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity

Adrian Schmid, Johan Auwerx, Norman Lionel Moullan, Hongbo Zhang, Solene Rietsch, Vincenzo Sorrentino, Davide D'Amico, Mario Romani, Francesca Potenza

Alzheimer's disease is a common and devastating disease characterized by aggregation of the amyloid-beta peptide. However, we know relatively little about the underlying molecular mechanisms or how to treat patients with Alzheimer's disease. Here we provid ...

2017

Parkin functionally interacts with PGC-1 proportional to to preserve mitochondria and protect dopaminergic neurons

Patrick Aebischer, Bernard Schneider, Graham Knott, Johan Auwerx, Darren Moore, Norman Lionel Moullan, Lu Zheng, Nathalie Marie Géraldine Bernard, Davide D'Amico

To understand the cause of Parkinson's disease (PD), it is important to determine the functional interactions between factors linked to the disease. Parkin is associated with autosomal recessive early-onset PD, and controls the transcription of PGC-1a, a m ...

Oxford University Press2017

Label-free three-dimensional imaging of Caenorhabditis elegans with visible optical coherence microscopy

Theo Lasser, Paul James Marchand, Séverine Coquoz, Johan Auwerx, Arno Pino Bouwens, Laurent Mouchiroud, Daniel Pawel Szlag, Vincenzo Sorrentino

Fast, label-free, high-resolution, three-dimensional imaging platforms are crucial for high-throughput in vivo time-lapse studies of the anatomy of Caenorhabditis elegans, one of the most commonly used model organisms in biomedical research. Despite the ne ...

Public Library of Science2017

The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress

Johan Auwerx, Maroun Bou Sleiman

Age-associated changes in chromatin structure have a major impact on organismal longevity. Despite being a central part of the ageing process, the organismal responses to the changes in chromatin organization remain unclear. Here we show that moderate dist ...

Nature Research2017

An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondria! metabolism

Johan Auwerx, Pénélope Andreux, Xu Wang

Objective: Strategies improving skeletal muscle mitochondrial capacity are commonly paralleled by improvements in (metabolic) health. We and others previously identified microRNAs regulating mitochondrial oxidative capacity, but data in skeletal muscle are ...

Elsevier Science Bv2017

Agents and methods using thereof for the prevention and treatment of stem cell muscle disorders

Johan Auwerx, Dongryeol Ryu, Hongbo Zhang, Keir Joe Menzies

Abstract of the invention: The present invention relates to agents that induce mitochondrial unfolded protein response (UPR mt ) in muscle stem cells and prevents or reverse process of muscle stem cell senescence. Further, the invention relates to methods ...

2017

The corepressor NCOR1 regulates the survival of single-positive thymocytes

Johan Auwerx

Nuclear receptor corepressor 1 (NCOR1) is a transcriptional regulator bridging repressive chromatin modifying enzymes with transcription factors. NCOR1 regulates many biological processes, however its role in T cells is not known. Here we show that Cd4-Cre ...

Nature Research2017

Modulating NAD(+) metabolism, from bench to bedside

Elena Katsyuba, Johan Auwerx

Discovered in the beginning of the 20(th) century, nicotinamide adenine dinucleotide (NAD(+)) has evolved from a simple oxidoreductase cofactor to being an essential cosubstrate for a wide range of regulatory proteins that include the sirtuin family of NAD ...

Wiley2017

Plasma Membrane-bound G Protein-coupled Bile Acid Receptor Attenuates Liver Ischemia/Reperfusion Injury Via the Inhibition of Toll-like Receptor 4 Signaling in Mice

Kristina Schoonjans, Johan Auwerx, Xu Wang

The plasma membrane-bound G protein-coupled bile acid receptor (TGR5) displays varied levels of expression in different tissues. TGR5-induced liver protection has been demonstrated during several liver diseases, except during ischemia/reperfusion injury (I ...

Wiley2017

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

Johan Auwerx, Dongryeol Ryu

Reduced mitochondria! electron transport chain activity promotes longevity and improves energy homeostasis via cell-autonomous and non-autonomous factors in multiple model systems. This mitohormetic effect is thought to involve the mitochondrial unfolded p ...

Rockefeller University Press2017

Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia

Johan Auwerx

Severe neonatal hyperbilirubinemia (SNH) and the onset of bilirubin encephalopathy and kernicterus result in part from delayed expression of UDP-glucuronosyltransferase 1A1 (UGT1A1) and the inability to metabolize bilirubin. Although there is a good unders ...

National Academy of Sciences2017

Systems Phytohormone Responses to Mitochondrial Proteotoxic Stress

Johan Auwerx, Xu Wang

Mitochondrial function is controlled by two separate genomes. This feature makes mitochondria prone to proteotoxic stress when a stoichiometric imbalance occurs in the protein complexes that perform oxidative phosphorylation, which consist of both nucleara ...

Cell Press2017

The effects of mitochondrial- and histone stress on the C. elegans transcriptome

Johan Auwerx, Maroun Bou Sleiman, Pedro Moral Quiros

The aim of this study was to explore whether mitochondrial- and histone stress cause any common changes in global gene expression. For this experiment, we performed RNA sequencing from control RNAi, cco-1 RNAi (mitochondrial stress) and his-3 RNAi (histone ...

EPFL Infoscience2017

Mitochondria and Epigenetics Crosstalk in Homeostasis and Stress

Johan Auwerx

Through epigenetic mechanisms cells integrate environmental stimuli to fine-tune gene expression levels. Mitochondrial function is essential to provide the intermediate metabolites necessary to generate and modify epigenetic marks in the nucleus, which in ...

Elsevier Science London2017

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

Johan Auwerx, Davide D'Amico

Mitochondrial stress activates a mitonuclear response to safeguard and repair mitochondrial function and to adapt cellular metabolism to stress. Using a multiomics approach in mammalian cells treated with four types of mitochondrial stressors, we identify ...

Rockefeller University Press2017

Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle

Chiara Greggio, Johan Auwerx, Carlos Canto Alvarez, Xu Wang, Pooja Jha

Mitochondrial dysfunction is a hallmark of multiple metabolic complications. Physical activity is known to increase mitochondrial content in skeletal muscle, counteracting age-related decline in muscle function and protecting against metabolic and cardiova ...

Cell Press2017

A multiscale study of the role of dynamin in the regulation of glucose uptake

Martinus Gijs, Kristina Schoonjans, Johan Auwerx, Laurent Mouchiroud, Keir Joe Menzies, Raphaël Etienne Jean Trouillon, Maria Cristina Letizia

Glucose uptake in muscle cells in response to insulin is a fundamental mechanism for metabolism. The inability of cells to mobilize the specific glucose transporter GLUT4 is believed to be at least partially accountable for diseases, like diabetes, where c ...

Royal Soc Chemistry2017

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