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Johan Auwerx

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Publications associées (266)

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Intestinal steroidogenesis controls PPAR expression in the colon and is impaired during ulcerative colitis

Johan Auwerx

Background and aims Immune tolerance breakdown during UC involves the peroxisome proliferator-activated receptor- (PPAR), a key factor in mucosal homoeostasis and the therapeutic target of 5-aminosalycilates, which expression is impaired during UC. Here we ...

Bmj Publishing Group2015

NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

Changmyung Oh, Johan Auwerx, Hongbo Zhang, Hao Li, Vincenzo Sorrentino, Tanes Imamura de Lima, Mario Romani

Aging is characterized by loss of proteostasis and mitochondrial homeostasis. Here, we provide bioinformatic evidence of dysregulation of mitochondrial and proteostasis pathways in muscle aging and diseases. Moreover, we show accumulation of amyloid-like d ...

2021

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

Johan Auwerx, Patrick Aebischer, Dongryeol Ryu, Pénélope Andreux

Urolithin A (UA) is a natural dietary, microflora-derived metabolite shown to stimulate mitophagy and improve muscle health in old animals and in preclinical models of aging(1). Here, we report the results of a first-in-human clinical trial in which we adm ...

NATURE PUBLISHING GROUP2019

Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease

Johan Auwerx, Adrienne Joëlle Laurence Mottis, Elena Katsyuba

Background. Nicotinamide adenine dinucleotide (NAD(+)) is a ubiquitous coenzyme involved in electron transport and a cosubstrate for sirtuin function. NAD(+) deficiency has been demonstrated in the context of acute kidney injury (AKI). Methods. We studied ...

2021

Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer

Johan Auwerx, Bo Li

SIRT5 is a member of the sirtuin family of NAD(+)-dependent protein lysine deacylases implicated in a variety of physiological processes. SIRT5 removes negatively charged malonyl, succinyl, and glutaryl groups from lysine residues and thereby regulates mul ...

SPRINGERNATURE2021

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

Johan Auwerx, Hao Li, Davide D'Amico, Pénélope Andreux, Tanes Imamura de Lima, Pirkka-Pekka Untamo Laurila, Martin Rainer Wohlwend, Peiling Luan

Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy, and despite advances in genetic and pharmacological disease-modifying treatments, its management remains a major challenge. Mitochondrial dysfunction contributes to DMD, yet the mecha ...

AMER ASSOC ADVANCEMENT SCIENCE2021

NAD(+) homeostasis in health and disease

Johan Auwerx, Elena Katsyuba, Mario Romani, Dina Hofer

The conceptual evolution of nicotinamide adenine dinucleotide (NAD(+)) from being seen as a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and longevity, including the sirtuin family of protein deacylases, has led to ...

2020

The mouse metallomic landscape of aging and metabolism

Johan Auwerx, Richardus Houtkooper, Pooja Jha, Jean-David Horacio Morel, Ludger Jan Elzuë Goeminne, Evan Graehl Williams

The metallome is crucial for normal cell functioning but remains largely overlooked in mammals. Here the authors analyze the metallome and copper and zinc isotope compositions in aging mice and show networks of interactions that are organ-specific, age-dep ...

Nature Research2022

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

Johan Auwerx, Jun Yong Kim, Kristina Schoonjans, Alessia Perino, Dongryeol Ryu, Elena Katsyuba, Hongbo Zhang, Keir Joe Menzies, Pooja Jha, Karim Laurent Gariani, Vera Monica Lemos Da Silva

Background & Aims: To date, no pharmacological therapy has been approved for non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to evaluate the therapeutic potential of poly ADP-ribose polymerase (PARP) inhibitors in mouse models o ...

Elsevier Science Bv2017

A lysosomal surveillance response to stress extends healthspan

Johan Auwerx, Xiaoxu Li, Yang Li, Tanes Imamura de Lima, Jia Liu, Wen Gao, Qi Wang, Amélia Lalou

Lysosomes are cytoplasmic organelles central for the degradation of macromolecules to maintain cellular homoeostasis and health. However, how lysosomal activity can be boosted to counteract ageing and ageing-related diseases remains elusive. Here we reveal ...

Springer Science and Business Media LLC2025

The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Xiaoxu Li, Hao Li, Hadrien Charles Edouard Demagny, Yu Sun, Vera Monica Lemos Da Silva, Francesca Pontanari, Nadia Bresciani

Background & Aims: Transporters of the SLC25 mitochondrial carrier superfamily bridge cytoplasmic and mitochondrial metabolism by channeling metabolites across mitochondrial membranes and are pivotal for metabolic homeostasis. Despite their physiological r ...

ELSEVIER2022

Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel

Johan Auwerx, Bart Deplancke, Adamantia Kapopoulou, Maria Litovchenko, Brian Dennis Hollis, Roel Paulus Josephus Bevers, Virginie Sandra Braman

The nature and extent of mitochondrial DNA variation in a population and how it affects traits is poorly understood. Here we resequence the mitochondrial genomes of 169 Drosophila Genetic Reference Panel lines, identifying 231 variants that stratify along ...

2019

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

Johan Auwerx, Bart Deplancke, Laurent Mouchiroud, Richardus Houtkooper, Evan Graehl Williams, Dongryeol Ryu, Norman Lionel Moullan, Adrienne Joëlle Laurence Mottis, Xu Wang, Michael Vincent Frochaux, Virginija Jovaisaite

In recent years, tetracyclines, such as doxycycline, have become broadly used to control gene expression by virtue of the Tet-on/Tet-off systems. However, the wide range of direct effects of tetracycline use has not been fully appreciated. We show here tha ...

Elsevier2015

Porphyran from discolored nori prevents metabolic syndrome through microbiota-bile acid-ceramide pathway

Johan Auwerx, Alessia Perino, Adrienne Joëlle Laurence Mottis, Jean-David Horacio Morel

Nori is a component of the traditional Japanese diet. The Japanese have a low prevalence of obesity and cardiovascular disease worldwide, and components of nori may have disease-preventive effects. Here, we focused on porphyran, which is abundant in nori t ...

2025

Estrogen-related receptor gamma regulates mitochondrial and synaptic genes and modulates vulnerability to synucleinopathy

Johan Auwerx

Many studies implicate mitochondrial dysfunction as a key contributor to cell loss in Parkinson disease (PD). Previous analyses of dopaminergic (DAergic) neurons from patients with Lewy-body pathology revealed a deficiency in nuclear-encoded genes for mito ...

NATURE PORTFOLIO2022

The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice

Johan Auwerx, Kristina Schoonjans

Studies in rodents have shown that male sexual function can be disrupted by fetal or neonatal administration of compounds that alter endocrine homeostasis, such as the synthetic nonsteroidal estrogen diethylstilbestrol (DES). Although the molecular basis f ...

American Society for Clinical Investigation2009

PPAR gamma Ligands Switched High Fat Diet-Induced Macrophage M2b Polarization toward M2a Thereby Improving Intestinal Candida Elimination

Johan Auwerx

Obesity is associated with a chronic low-grade inflammation that predisposes to insulin resistance and the development of type 2 diabetes. In this metabolic context, gastrointestinal (GI) candidiasis is common. We recently demonstrated that the PPAR gamma ...

Public Library of Science2010

Calorie restriction: is AMPK a key sensor and effector?

Johan Auwerx, Carlos Canto Alvarez

Dietary restriction can extend life span in most organisms tested to date, suggesting that mechanisms sensing nutrient and energy availability might regulate longevity. The AMP-activated protein kinase (AMPK) has emerged as a key energy sensor with the abi ...

2011

CycloZ improves pulmonary fibrosis in bleomycin-induced idiopathic pulmonary fibrosis model mice by modulating the pathogenic transcriptome

Johan Auwerx, Xiaoxu Li

European Respiratory Soc Journals Ltd2023

Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity

Johan Auwerx, Tanes Imamura de Lima

Sustained ryanodine receptor (RyR) Ca2+ leak is associated with pathological conditions such as heart failure or skeletal muscle weakness. We report that a single session of sprint interval training (SIT), but not of moderate intensity continuous training ...

Nature Portfolio2021