Angela Casini

Cette personne n’est plus à l’EPFL

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Publications associées (43)

Stability of an organometallic ruthenium-ubiquitin adduct in the presence of glutathione: Relevance to antitumor activity

Paul Joseph Dyson, Céline Rita Duhot, Yury Tsybin, Christian Hartinger, Angela Casini

The interactions of the ruthenium(II) complex Ru(η6-p-cymene)(pta)Cl2 (RAPTA-C), an effective anticancer and antimetastatic agent, with biol. nucleophiles are important with respect to its mechanism of action, for example, the reaction with glutathione (GS ...

2008

Mass spectrometric analysis of ubiquitin-platinum interactions of leading anticancer drugs: MALDI versus ESI

Paul Joseph Dyson, Wee Han Ang, Christian Hartinger, Angela Casini

The protein binding of anticancer metallodrugs is regarded as an important part in their mode of action both for delivering the active moiety into the tumor but also being responsible for deactivation and/or unwanted side effects. Characterization of prote ...

2007

ESI-MS characterisation of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexes

Paul Joseph Dyson, Wee Han Ang, Angela Casini

Electrospray ionization mass spectrometry allows a rapid characterization of the adducts formed between three novel anticancer ruthenium(II)-arene PTA compds. and horse heart cytochrome c or hen egg white lysozyme. Specific information on the nature of the ...

2007

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