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Bruno Lemaitre

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Publications associées (128)

Insect endosymbiont proliferation is limited by lipid availability

Bruno Lemaitre, Jeremy Keith Herren, Juan Camilo Paredes Escobar

Spiroplasma poulsonii is a maternally transmitted bacterial endosymbiont that is naturally associated with Drosophila melanogaster. S. poulsonii resides extracellularly in the hemolymph, where it must acquire metabolites to sustain proliferation. In this s ...

Elife Sciences Publications Ltd2014

Methods to study Drosophila immunity

Bruno Lemaitre, Olivier Binggeli, Andrew Jonathan Bretscher

Innate immune mechanisms are well conserved throughout evolution, and many theoretical concepts, molecular pathways and gene networks are applicable to invertebrate model organisms as much as vertebrate ones. Drosophila immunity research benefits from an e ...

Elsevier2014

Prophenoloxidase Activation Is Required for Survival to Microbial Infections in Drosophila

Bruno Lemaitre, Olivier Binggeli

The melanization reaction is a major immune response in Arthropods and involves the rapid synthesis of melanin at the site of infection and injury. A key enzyme in the melanization process is phenoloxidase (PO), which catalyzes the oxidation of phenols to ...

Public Library of Science2014

Transforming Growth Factor beta/Activin Signaling Functions as a Sugar-Sensing Feedback Loop to Regulate Digestive Enzyme Expression

Bruno Lemaitre, Wen Bin Chng, Maroun Bou Sleiman

Organisms need to assess their nutritional state and adapt their digestive capacity to the demands for various nutrients. Modulation of digestive enzyme production represents a rational step to regulate nutriment uptake. However, the role of digestion in n ...

Elsevier2014

Microbiota-Induced Changes in Drosophila melanogaster Host Gene Expression and Gut Morphology

Bruno Lemaitre, Nichole Broderick

To elucidate mechanisms underlying the complex relationships between a host and its microbiota, we used the genetically tractable model Drosophila melanogaster. Consistent with previous studies, the microbiota was simple in composition and diversity. Howev ...

American Society for Microbiology2014

Translation inhibition and metabolic stress pathways in the host response to bacterial pathogens

Bruno Lemaitre

Activation of most major innate immune signalling cascades relies on the detection of microorganisms or their associated danger signals by host pattern recognition molecules. A flurry of recent studies has now uncovered a role for host translation inhibiti ...

Nature Publishing Group2013

dRYBP Contributes to the Negative Regulation of the Drosophila Imd Pathway

Bruno Lemaitre

The Drosophila humoral innate immune response fights infection by producing antimicrobial peptides (AMPs) through the microbe-specific activation of the Toll or the Imd signaling pathway. Upon systemic infection, the production of AMPs is both positively a ...

Public Library of Science2013

Functional Analysis of PGRP-LA in Drosophila Immunity

Bruno Lemaitre, Nichole Broderick, Juan Camilo Paredes Escobar

PeptidoGlycan Recognition Proteins (PGRPs) are key regulators of the insect innate antibacterial response. Even if they have been intensively studied, some of them have yet unknown functions. Here, we present a functional analysis of PGRP-LA, an as yet unc ...

Public Library of Science2013

Crystallization and preliminary X-ray analysis of monalysin, a novel beta-pore-forming toxin from the entomopathogen Pseudomonas entomophila

Bruno Lemaitre, Onya Opota

Monalysin was recently described as a novel pore-forming toxin (PFT) secreted by the Drosophila pathogen Pseudomonas entomophila. Recombinant monalysin is multimeric in solution, whereas PFTs are supposed to be monomeric until target membrane association. ...

International Union of Crystallography2013

Vertical transmission of a Drosophila endosymbiont via cooption of the yolk transport and internalization machinery

Bruno Lemaitre, Jeremy Keith Herren, Juan Camilo Paredes Escobar, Fanny Schüpfer

Spiroplasma is a diverse bacterial clade that includes many vertically transmitted insect endosymbionts, including Spiroplasma poulsonii, a natural endosymbiont of Drosophila melanogaster. These bacteria persist in the hemolymph of their adult host and exh ...

American Society for Microbiology2013

The Digestive Tract of Drosophila melanogaster

Bruno Lemaitre

The digestive tract plays a central role in the digestion and absorption of nutrients. Far from being a passive tube, it provides the first line of defense against pathogens and maintains energy homeostasis by exchanging neuronal and endocrine signals with ...

2013

Morphological and Molecular Characterization of Adult Midgut Compartmentalization in Drosophila

Jean Philippe Boquete, Bruno Lemaitre, Bart Deplancke, Dani Osman

Although the gut is a central organ of Eumetazoans and is essential for organismal health, our understanding of its morphological and molecular determinants remains rudimentary. Here, we provide a comprehensive atlas of Drosophila adult midgut. Specificall ...

Elsevier2013

Gut homeostasis in a microbial world: insights from Drosophila melanogaster

Bruno Lemaitre, Nichole Broderick

Intestinal homeostasis is achieved, in part, by the integration of a complex set of mechanisms that eliminate pathogens and tolerate the indigenous microbiota. Drosophila melanogaster feeds on microorganism-enriched matter and therefore has developed effic ...

Nature Publishing Group2013

Tissue- and ligand-specific sensing of gram-negative infection in drosophila by PGRP-LC isoforms and PGRP-LE

Bruno Lemaitre

The Drosophila antimicrobial response is one of the best characterized systems of pattern recognition receptor-mediated defense in metazoans. Drosophila senses Gram-negative bacteria via two peptidoglycan recognition proteins (PGRPs), membrane-bound PGRP-L ...

American Association of Immunologists ; Oxford University Press2012

Distinguishing dead from alive - a novel intracellular receptor mediates ligand-specific regulation of Relish-dependent immune activation in Drosophila

Bruno Lemaitre

Wiley-Blackwell2012

The drosophila gut: A new paradigm for epithelial immune response

Bruno Lemaitre

Academic Press Ltd- Elsevier Science Ltd2012

Gut-associated microbes of Drosophila melanogaster

Bruno Lemaitre, Nichole Broderick

There is growing interest in using Drosophila melanogaster to elucidate mechanisms that underlie the complex relationships between a host and its microbiota. In addition to the many genetic resources and tools Drosophila provides, its associated microbiota ...

2012

Autocrine and paracrine unpaired signalling regulate intestinal stem cell maintenance and division

Bruno Lemaitre, Sveta Chakrabarti, Dani Osman, Yu-Chen Tsai, Yu-Ting Huang

The Janus Kinase (JAK) Signal Transducer and Activator of Transcription (STAT) pathway is involved in the regulation of Intestinal Stem Cell (ISC) activity to ensure a continuous renewal of the adult Drosophila midgut. Three ligands, Unpaired1, 2 and 3 are ...

Company Of Biologists Ltd2012

Insect-microbe interactions: the good, the bad and the others

Bruno Lemaitre, Jeremy Keith Herren

Current Biology Ltd2012

Taxonomic characterisation of Pseudomonas strain L48 and formal proposal of Pseudomonas entomophila sp nov

Bruno Lemaitre

An entomopathogenic, Gram-negative bacterium isolated from a female specimen of the fruit fly Drosophila melanogaster was taxonomically characterised. Strain L48(T) was strictly aerobic, non-fermentative, oxidase and catalase positive, rod-shaped, and moti ...

Elsevier2012

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