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Cristina Ramona Cudalbu Moldovan

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Publications associées (122)

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Probiotics combined with rifaximin influence the neurometabolic changes in a rat model of type C HE

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan, Katarzyna Pierzchala, Emmanuelle Ines Flatt

Type C hepatic encephalopathy (HE) is a neuropsychiatric disease caused by chronic liver disease. Management of type C HE remains an important challenge because treatment options are limited. Both the antibiotic rifaximin and probiotics have been reported ...

Nature Portfolio2021

Lessons on brain edema in HE: from cellular to animal models and clinical studies

Cristina Ramona Cudalbu Moldovan, Katarzyna Pierzchala, Jessie Julie Mosso

Brain edema is considered as a common feature associated with hepatic encephalopathy (HE). However, its central role as cause or consequence of HE and its implication in the development of the neurological alterations linked to HE are still under debate. I ...

SPRINGER/PLENUM PUBLISHERS2023

Contribution of macromolecules to brain H-1 MR spectra: Experts' consensus recommendations

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan, Lijing Xin, Hongxia Lei, Dunja Simicic, Veronika Rackayová

Proton MR spectra of the brain, especially those measured at short and intermediate echo times, contain signals from mobile macromolecules (MM). A description of the main MM is provided in this consensus paper. These broad peaks of MM underlie the narrower ...

WILEY2020

Clinical Proton MR Spectroscopy in Central Nervous System Disorders

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan

A large body of published work shows that proton (hydrogen 1 [(1)H]) magnetic resonance (MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality. Herein, the authors present a summary of brain disorders in which MR spectrosc ...

2014

Diffusion-Weighted Spectroscopy: A Novel Approach to Determine Macromolecule Resonances in Short-Echo Time H-1-MRS

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan, Nicolas Kunz

Quantification of short-echo time proton magnetic resonance spectroscopy results in >18 metabolite concentrations (neurochemical profile). Their quantification accuracy depends on the assessment of the contribution of macromolecule (MM) resonances, previou ...

Wiley-Blackwell2010

Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan, Lijing Xin, Bernard Lanz

In vivo MRS is a non-invasive measurement technique used not only in humans, but also in animal models using high-field magnets. MRS enables the measurement of metabolite concentrations as well as metabolic rates and their modifications in healthy animals ...

WILEY2020

Overview of oxidative stress findings in hepatic encephalopathy: From cellular and ammonium-based animal models to human data

Cristina Ramona Cudalbu Moldovan, Dunja Simicic

Oxidative stress is a natural phenomenon in the body. Under physiological conditions intracellular reactive oxygen species (ROS) are normal components of signal transduction cascades, and their levels are maintained by a complex antioxidants systems partic ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2022

(1)H and (31)P magnetic resonance spectroscopy in a rat model of chronic hepatic encephalopathy: in vivo longitudinal measurements of brain energy metabolism

Cristina Ramona Cudalbu Moldovan, Bernard Lanz, Veronika Rackayová

Chronic liver disease (CLD) leads to a spectrum of neuropsychiatric disorders named hepatic encephalopathy (HE). Even though brain energy metabolism is believed to be altered in chronic HE, few studies have explored energy metabolism in CLD-induced HE, and ...

Springer Verlag2016

Late post‐natal neurometabolic development in healthy male rats using 1 H and 31 P Magnetic Resonance Spectroscopy

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan, Veronika Rackayová, Guillaume Donati, Dunja Simicic

Brain metabolism evolves rapidly during early post‐natal development in the rat. While changes in amino acids, energy metabolites, antioxidants or metabolites involved in phospholipid metabolism have been reported in the early stages, neurometabolic change ...

2021

Central nervous system and systemic oxidative stress interplay with inflammation in a bile duct ligation rat model of type C hepatic encephalopathy

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan, Andrzej Sienkiewicz, Dunja Simicic, Katarzyna Pierzchala, Stefanita-Octavian Mitrea

The role and coexistence of oxidative stress (OS) and inflammation in type C hepatic encephalopathy (C HE) is a subject of intense debate. Under normal conditions the physiological levels of intracellular reactive oxygen species are controlled by the count ...

2022

Diffusion-weighted SPECIAL improves the detection of J-coupled metabolites at ultrahigh magnetic field

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan, Bernard Lanz, Dunja Simicic, Jessie Julie Mosso

PurposeTo improve the detection and subsequent estimation of the diffusion properties of strongly J-coupled metabolites in diffusion-weighted MRS (DWS).MethodsA new sequence for single-voxel diffusion-weighted 1H MR spectroscopy, named DW-SPECIAL, is propo ...

WILEY2023

In vivo characterization of brain metabolism by 1 H MRS, 13 C MRS and 18 FDG PET reveals significant glucose oxidation of invasively growing glioma cells

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan, Bernard Lanz, Carole Poitry-Yamate, Marta Lai

Glioblastoma are notorious for their highly invasive growth, diffusely infiltrating adjacent brain structures that precludes complete resection, and is a major obstacle for cure. To characterize this "invisible" tumor part, we designed a high resolution mu ...

2018

In vivo macromolecule signals in rat brain 1 H‐MR spectra at 9.4T: Parametrization, spline baseline estimation, and T 2 relaxation times

Cristina Ramona Cudalbu Moldovan, Lijing Xin, Bernard Lanz, Dunja Simicic, Veronika Rackayová

Purpose Reliable detection and fitting of macromolecules (MM) are crucial for accurate quantification of brain short-echo time (TE) 1H-MR spectra. An experimentally acquired single MM spectrum is commonly used. Higher spectral resolution at ultra-high fiel ...

Wiley2021

Ammonia toxicity to the brain

Cristina Ramona Cudalbu Moldovan

Hyperammonemia can be caused by various acquired or inherited disorders such as urea cycle defects. The brain is much more susceptible to the deleterious effects of ammonium in childhood than in adulthood. Hyperammonemia provokes irreversible damage to the ...

Springer Verlag2013

A new rat model of creatine transporter deficiency reveals behavioral disorder and altered brain metabolism

Hirotaka Yamada, Maria del Carmen Sandi Perez, Cristina Ramona Cudalbu Moldovan, Dunja Simicic, Jocelin Grosse

Creatine is an organic compound used as fast phosphate energy buffer to recycle ATP, important in tissues with high energy demand such as muscle or brain. Creatine is taken from the diet or endogenously synthetized by the enzymes AGAT and GAMT, and specifi ...

Nature Research2021

Brain Edema in Chronic Hepatic Encephalopathy

Cristina Ramona Cudalbu Moldovan

Brain edema is a common feature associated with hepatic encephalopathy (HE). In patients with acute HE, brain edema has been shown to play a crucial role in the associated neurological deterioration. In chronic HE, advanced magnetic resonance imaging (MRI) ...

ELSEVIER - DIVISION REED ELSEVIER INDIA PVT LTD2019

The first knock-in rat model for glutaric aciduria type I allows further insights into pathophysiology in brain and periphery

Cristina Ramona Cudalbu Moldovan

Glutaric aciduria type I (GA-I, OMIM # 231670) is an inborn error of metabolism caused by a deficiency of glutaryl-CoA dehydrogenase (GCDH). Patients develop acute encephalopathic crises (AEC) with striatal injury most often triggered by catabolic stress. ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2021

RETRACTED: Marker-independent identification of glioma-initiating cells

Rolf Gruetter, Cristina Ramona Cudalbu Moldovan

Tumor-initiating cells with stem cell properties are believed to sustain the growth of gliomas, but proposed markers such as CD133 cannot be used to identify these cells with sufficient specificity. We report an alternative isolation method purely based on ...

Nature Publishing Group2010

Hyperpolarized Lithium-6 as a Sensor of Nanomolar Contrast Agents

Rolf Gruetter, Arnaud Comment, Cristina Ramona Cudalbu Moldovan, Sami Jannin, Chiara Perazzolo, Jacques Van Der Klink, Ruud van Heeswijk

Lithium is widely used in psychotherapy. The Li-6 isotope has a long intrinsic longitudinal relaxation time T-1 on the order of minutes, making it an ideal candidate for hyperpolarization experiments. In the present study we demonstrated that lithium-6 can ...

Wiley-Blackwell2009

Hyperpolarized C-13-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma

Rolf Gruetter, Arnaud Comment, Cristina Ramona Cudalbu Moldovan, Bernard Lanz, Mor-Miri Mishkovsky, Jocelyne Bloch

Glioblastoma (GBM) is the most aggressive brain tumor type in adults. GBM is heterogeneous, with a compact core lesion surrounded by an invasive tumor front. This front is highly relevant for tumor recurrence but is generally non-detectable using standard ...

Nature Research2021