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Stewart Cole

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Publications associées (262)

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Search for lepton and baryon number violating τ- decays into Λ̄π- and Λπ-

Olivier Schneider, Chao Wang, Lei Zhang, Vladislav Balagura, Stewart Cole, Sun Hee Kim

We have searched for τ lepton decays, τ-→Λ̄π- and τ-→Λπ-, that simultaneously violate the conservation of the lepton (L) and baryon (B) number using a data sample of 154 fb-1 collected with the Belle detector at the KEKB e+e- asymmetric-energy collider. No ...

2006

Search for lepton flavor violating τ- decays with a KS 0 meson

Olivier Schneider, Chao Wang, Lei Zhang, Stewart Cole

We have searched for the lepton flavor violating decays τ- → ℓ- KS 0 (ℓ = e or μ), using a data sample of 281 fb-1 collected with the Belle detector at the KEKB e+ e- asymmetric-energy collider. No evidence for a signal was found in either of the decay mod ...

2006

High resolution CryoEM structure of the ring-shaped virulence factor EspB from Mycobacterium tuberculosis

Stewart Cole, Florence Pojer, Jérémie Piton

The EspB protein of Mycobacterium tuberculosis is a 60 kDa virulence factor, implicated in conjugation and exported by the ESX-1 system of which it may also be a component. Previous attempts to obtain high-resolution maps of EspB by cryo-electron microscop ...

2020

Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis

Paul Joseph Dyson, Stewart Cole, John McKinney, Florence Pojer, Neeraj Dhar, Joao Pedro De Almeida Neres

The benzothiazinone BTZ043 is a tuberculosis drug candidate with nanomolar whole-cell activity. BTZ043 targets the DprE1 catalytic component of the essential enzyme decaprenylphosphoryl-beta-D-ribofuranose-2'-epimerase, thus blocking biosynthesis of arabin ...

American Association for the Advancement of Science2012

The PhoP-Dependent ncRNA Mcr7 Modulates the TAT Secretion System in Mycobacterium tuberculosis

Stewart Cole, Jacques Rougemont, Claudia Sala, Andrej Benjak, Swapna Uplekar

The PhoPR two-component system is essential for virulence in Mycobacterium tuberculosis where it controls expression of approximately 2% of the genes, including those for the ESX-1 secretion apparatus, a major virulence determinant. Mutations in phoP lead ...

Public Library of Science2014

Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer

Stewart Cole

Mycobacterium ulcerans is found in aquatic ecosystems and causes Buruli ulcer in humans, a neglected but devastating necrotic disease of subcutaneous tissue that is rampant throughout West and Central Africa. Here, we report the complete 5.8-Mb genome sequ ...

2007

Detection and Strain Typing of Ancient Mycobacterium leprae from a Medieval Leprosy Hospital

Stewart Cole, Pushpendra Singh

Nine burials excavated from the Magdalen Hill Archaeological Research Project (MHARP) in Winchester, UK, showing skeletal signs of lepromatous leprosy (LL) have been studied using a multidisciplinary approach including osteological, geochemical and biomole ...

Public Library of Science2013

Early trafficking events of Mycobacterium ulcerans within Naucoris cimicoides

Stewart Cole

The severe skin-destructive disease caused by Mycobacterium ulcerans, named Buruli ulcer, is the third most important mycobacterial disease in humans after tuberculosis and leprosy. Recently we demonstrated that M. ulcerans could colonize the salivary glan ...

2006

Search for neutrinoless decays τ → ℓ h h and τ → ℓ V0

Olivier Schneider, Aurelio Bay, Stewart Cole, Sun Hee Kim

We have searched for neutrinoless τ lepton decays into ℓhh or ℓ V0, where ℓ stands for an electron or muon, h for a charged light hadron, π or K, and V0 for a neutral vector meson, ρ0, K* (892)0 and φ{symbol}, using a 158 fb-1 data sample collected with th ...

2006

Design, Synthesis and in vitro Controlled Release of New Adamantanodiarylketone Antimycobacterials

Stewart Cole, Anthony Vocat

In the present investigation, the synthesis, the biology and the development of matrix tablet formulations for the in vitro controlled release of new adamantane diarylketone antimycobacterial derivatives, is presented. In the skeleton of the new compounds, ...

WILEY-V C H VERLAG GMBH2019

Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros

Stefanie Boy-Röttger, Stewart Cole, Andrej Benjak, Charlotte Avanzi, Pushpendra Singh, Philippe Busso

Human settlement of Madagascar traces back to the beginning of the first millennium with the arrival of Austronesians from Southeast Asia, followed by migrations from Africa and the Middle East. Remains of these different cultural, genetic, and linguistic ...

Frontiers Media SA2020

Virulence Regulator EspR of Mycobacterium tuberculosis Is a Nucleoid-Associated Protein

Stewart Cole, Jacques Rougemont, Claudia Sala, Florence Pojer, Ruben Hartkoorn, Swapna Uplekar, Benjamin Blasco

The principal virulence determinant of Mycobacterium tuberculosis (Mtb), the ESX-1 protein secretion system, is positively controlled at the transcriptional level by EspR. Depletion of EspR reportedly affects a small number of genes, both positively or neg ...

Public Library of Science2012

Comparative genomics of Esx genes from clinical isolates of Mycobacterium tuberculosis provides evidence for gene conversion and epitope variation

Stewart Cole, Jacques Rougemont, Swapna Uplekar

The 23-membered Esx protein family is involved in the host-pathogen interactions of Mycobacterium tuberculosis. These secreted proteins are among the most immunodominant antigens recognized by the human immune system and have thus been used to develop vacc ...

2011

Measurements of branching fractions and q2 distributions for B → π ℓ ν and B → ρ ℓ ν decays with B → D(*) ℓ ν decay tagging

Mingkui Wang, Olivier Schneider, Chao Wang, Lei Zhang, Aurelio Bay, Vladislav Balagura, Stewart Cole

We report measurements of the charmless semileptonic decays B0 → π- / ρ- ℓ+ ν and B+ → π0 / ρ0 ℓ+ ν, based on a sample of 2.75 × 108B over(B, ̄) events collected at the Υ{hooked} (4 S) resonance with the Belle detector at the KEKB e+ e- asymmetric collider ...

2007

Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c

Stewart Cole, Raju Mukherjee, Sophie Magnet

Among the few proteins shown to be secreted by the Tat system in Mycobacterium tuberculosis, Rv2525c is of particular interest, since its gene is conserved in the minimal genome of Mycobacterium leprae. Previous evidence linked this protein to cell wall me ...

Elsevier2014

Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme

Stewart Cole, Florence Pojer

The transketolase (TKT) enzyme in Mycobacterium tuberculosis represents a novel drug target for tuberculosis treatment and has low homology with the orthologous human enzyme. Here, we report on the structural and kinetic characterization of the transketola ...

Royal Soc2012

Probable zoonotic leprosy in the southern United States

Stewart Cole, Jacques Rougemont, Philippe Busso, Pushpendra Singh, Adamantia Kapopoulou, Rahul Sharma

In the southern region of the United States, such as in Louisiana and Texas, there are autochthonous cases of leprosy among native-born Americans with no history of foreign exposure. In the same region, as well as in Mexico, wild armadillos are infected wi ...

2011

Inhibiting Mycobacterium tuberculosis within and without

Stewart Cole

Tuberculosis remains a scourge of global health with shrinking treatment options due to the spread of drug-resistant strains of Mycobacterium tuberculosis. Intensive efforts have been made in the past 15 years to find leads for drug development so that bet ...

Royal Soc2016

Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis

Stewart Cole, John McKinney, Claudia Sala, Neeraj Dhar, Giulia Manina

New drugs are required to counter the tuberculosis (TB) pandemic. Here, we describe the synthesis and characterization of 1,3-benzothiazin-4-ones (BTZs), a new class of antimycobacterial agents that kill Mycobacterium tuberculosis in vitro, ex vivo, and in ...

American Association for the Advancement of Science2009

In Vitro and In Vivo Activities of Three Oxazolidinones against Nonreplicating Mycobacterium tuberculosis

Stewart Cole, Neeraj Dhar, Claudia Sala, Anthony Vocat, Ming Zhang

Oxazolidinones represent a new class of antituberculosis drugs that exert their function by inhibiting protein synthesis. Here, we compared the activities of three oxazolidinones, linezolid, PNU-100480, and AZD5847, against latent tuberculosis using a simp ...

Amer Soc Microbiology2014